DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science (New York, N.Y.) 2018 imex curation Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au Accepted 2018-JUL-31 AT 09:30 BST AT 09:30 BST by ORCHARD Science (New York, N.Y.) 2018 imex curation LS> no competition here - just diluted one of the participant. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science (New York, N.Y.) 2018 imex curation Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip weight by comassie molecular weight estimation by coomasie staining weight by comassie Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au Accepted 2018-JUL-31 AT 09:30 BST AT 09:30 BST by ORCHARD Science (New York, N.Y.) 2018 imex curation LS> no competition here - just diluted one of the participant. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science (New York, N.Y.) 2018 imex curation Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro fret fluorescent resonance energy transfer FRET RET FRET analysis FRET RET FRET analysis fret tag fluorescence tag visualisation by fluorescence tag fluorescence Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au Accepted 2018-JUL-31 AT 09:30 BST AT 09:30 BST by ORCHARD Science (New York, N.Y.) 2018 imex curation LS> no competition here - just diluted one of the participant. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science (New York, N.Y.) 2018 imex curation Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au Accepted 2018-JUL-31 AT 09:30 BST AT 09:30 BST by ORCHARD Science (New York, N.Y.) 2018 imex curation LS> no competition here - just diluted one of the participant. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science (New York, N.Y.) 2018 imex curation Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column weight by comassie molecular weight estimation by coomasie staining weight by comassie Gruszczyk J., Kanjee U., Chan LJ., Menant S., Malleret B., Lim NTY., Schmidt CQ., Mok YF., Lin KM., Pearson RD., Rangel G., Smith BJ., Call MJ., Weekes MP., Griffin MDW., Murphy JM., Abraham J., Sriprawat K., Menezes MJ., Ferreira MU., Russell B., Renia L., Duraisingh MT., Tham WH. tham@wehi.edu.au Accepted 2018-JUL-31 AT 09:30 BST AT 09:30 BST by ORCHARD Science (New York, N.Y.) 2018 imex curation LS> no competition here - just diluted one of the participant. trfe_human Serotransferrin Siderophilin Beta-1 metal-binding globulin TF PRO1400 protein protein human Homo sapiens Human MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP DIP protein P02787 original sequence version: 123 DIP protein P02787 original sequence version: 144 DIP protein P02787 original sequence version: 156 DIP protein P02787 original sequence version: 165 DIP protein P02787 original sequence version: 161 DIP protein P02787 original sequence version: 170 9A73B90D8C5671E9 tfr1_human Transferrin receptor protein 1 TFRC T9 p90 protein protein human Homo sapiens Human MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF DIP protein P02786 original sequence version: 191 DIP protein P02786 original sequence version: 117 DIP protein P02786 original sequence version: 139 DIP protein P02786 original sequence version: 146 DIP protein P02786 original sequence version: 137 DIP protein P02786 original sequence version: 150 DIP protein P02786 original sequence version: 160 DIP protein P02786 original sequence version: 190 C886F14000D90154 a5k736_plavs PVX_094255 protein protein Plasmodium vivax (strain Salvador I) Plasmodium vivax (strain Salvador I) MHIPIQPSPESTQITNTTDNIDYFDISDESNYYLISQLRPHFSNIYFFDEFKRYASYHTEIKRYEDIHKTKVNSLLNEASRAIGICNRAKNTVKGLINILENPQKFKTQRESYDVKLRQYEEKKEAFRGCLLNKNRKNLDQIKKINNEIRDLLEKLKCSQDCQTNVYFDMIKIYLVDFKKMPYENYDTFIKQYKNSYLSGVDMIRKIEKQIDNPVTINAIKFTQKEMGYIIDRFEYHLQKVKHSIDQVTALSDGVKPKQVTKNRLKEYYFNIGNYYSIFKFGKDSLNMLNKALIHKEKIVHNLLGELFGHLEERISKLIDSEYFITESNNIISQSEETLKLAEDVYDKNTKLIEDLTLYPHLEINEFKKDYDNNVEDLRESIIYIQSYVSSIKSAYRYNVLEKDSVESKQKNIPANSNAQKKVDELLSIIDSISYSNFSVAENFQKMKDYYKEIEKLKIKILQLIEAIKKYQQHVEELINKEKAVAILKEDINKIIEYIKGIIEKLKQLISANKDFDKIFQQVEQLINEALFNKDQFEHNKNDLHTKMKEIMHTFHERDLQQFLDNMSKFLKDQEASYQNADSKEKLDQLLTTVKAKQDELKEMKCDDIPDIIDNLKKESQNVLNLKDEVINKQFENMRTEMSSSLDQMTKEYNALKSSIEEYEAEKKGIENHKQNIIKRKNTFIVAEHENDEDVPEGKNTYNEFISNKDTILQKESAISNQMNTLEEKKRNRKTTLQTYGDAIQKLETYTEKKDEETKVLLDKFNTEVENFKLDEDEKSFNDAKSIVSNTINEVENENKNIDSIKKVNIAMKRSRSNQQSVEQLIRNKDNLLKEKMEKHFQKINTDEIIGQSAKANLLNNLESEKAIINEQLNDAHLNDLKLQIEKTLSYCEKSRENIKGNNGTHPEELNASEIEWEATKGKIETLNSNYQALNKNMDDIINKQHDEMIVLIDRDIKEKGKDIELKVEQRIQALEKMKAKLSSFDTNEDVKKYQSDINKEELIKLKEMSTAVLNKIDQNKNQLINVKTKSSGYVAESNGIKNKQTEPSQEKDKQIVYNTNRGDIEKVYKNIRDMYNELDDVEKEETTSNEVDNIEMQYDRLLINLLVQKINEENTKAKGLMEEIKSYIENIESVQAKMSDETREGATEFEFNQYQQSSLANDKKITEIVQHAINKKGEAERSKKTNEVKSIKNDVNTYMQQVIDEYNAMQKALGDIKNVNDLLISTSGRRIAEEISKSTNEAENFEKQAKGELGKINDIIEKMENQMVQAKEHENKIHINLEDKQIDEEVQKIRQIHEELINTKIAMNEHLSKTKAAKENCLSQVRNAERGKIKIDFLNNNKQSSNLKDVNMDHVTKNIADCVEHSKEVNKTENEAEKEHDLFLEYEKDITSILNRSSILGIETKSKKRKNEATKIMGQIEGEHSIIKTELQQSSENFKQLNEKYNLSEEKSMLANPTSTKANESIQYNIGKVKQNLLYIDNIAKEVDTILTNAQDSIRSISQISKLDGRNTLQMVEKEAADYVKYLDKITKEKELMNDKHKDLNPIKSDIANIETELKKHRKLFEIGLLNKVIEIAKTRKLYMDSVEQLLNSSINNFVTLFNGFNLKKYKIETSLDVYKGKISEFHTEFLQPYESIQNKEKRVLDPSVDFSAAKNMREEAQKEEKNIENVEKKTKKYLSDINKMESFTFIRNMRQTLDELSKTCKQEYAEVEGGHKDIEKIIEDIKSLNDESGSSAKLQQAEDKNSQMKAKVNHYSLKKEAHTILEQIVKSANFVGITIVTALQPSDLAAKASLQKAPELQFESQSKVTLESGQFLEKKNQLDVHENVQAAYNTVLQIYKYSDDIVRKQEKCEQLVKDGKDICLKFKSINEIKVMIQNSKGKESTLSAKVSHSFNKLSELNKIKCNDESYDAILETPSREELNKLRSTFKQEKDTIANQAKLSGYKTDFETHIGKLNDLAKIVDNLKASETLPKNIEEKKTSINLISTKLETIEKEIESINSSFDQLLEKGKKCEMTKYKLVRDSLSTKINDHSAIIKDNQKKATEYLTYIQNNHISIFKDIDMLNENLGEKSVSRYAIAKIEEANDLSAQLTAAVSEYEAIANSIRKEFTNISDHTEMDTLENEAKMLKEHYDNLINKKNIITELHNKINLIKLLEIRATSDKYVDIAELLGEVVKDQKKKLQEAKNKLDTLKDHIAVKEKELINHDSSFTLVSIKAFDEIYDDIKYNVGQLHTLEVTNFDELKKGKTYEENVTHLLNRRETLQNDLHNYEEKDKLKNTNIEMSNEENNQIRQTSEVIKKLESEFQNLLKIIQQSNTLCSNDNIKQFISDILKKVETIRERFVKNFPEREKYHQIEINYNEIKGIVKEVDTNPEISIFTEKINTYIRQKIRSAHHLEDAQKIKDIIEDVTSNYRKIKSKLSQVNNALDRIKIKKSEMDTLFESLSKENANNYNSAKYFLVDSDKIIKHLEDQVSKMSSLISYAEREIKELEEKVYSILNRPVIDNSASEQIKLLSDTQENDTDEAQKREFAEEQILNLPKQQIHSDEGNNNDMSTTDSANEEKQTGEEESQHEDQSQPRGIHSRVRLAEGIILGLSVFSGIIFISFRHKDEEKKDPESVGEQFEGNNNFNEDDKEEVIDVCFDNSDYSE 2A484C0A1AFDCF45 a5k736_plavs-tf-1 2 6 unspecified role unspecified role prey prey purified purified human Homo sapiens Human 7 unspecified role unspecified role prey prey purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. 8 unspecified role unspecified role bait bait purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) association association Fig 1C a5k736_plavs-tfrc-1 2 7 unspecified role unspecified role prey prey purified purified spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. 8 unspecified role unspecified role bait bait purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig 1C a5k736_plavs-tfrc-2 3 7 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain DyLight594 DyLight594 fluorescent dye fluorescent dye label fluorescent dye undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. 8 unspecified role unspecified role fluorescence donor fluorescence donor purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain DyLight488 DyLight488 fluorescent dye fluorescent dye label fluorescent dye undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig S2-B a5k736_plavs-tfrc-3 4 7 unspecified role unspecified role prey prey purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. 8 unspecified role unspecified role bait bait purified purified sufficient binding region sufficient binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig 3A, Fig 3B a5k736_plavs-tf-2 5 6 unspecified role unspecified role neutral component neutral component purified purified human-serum Homo sapiens serum Serum 7 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. 8 unspecified role unspecified role neutral component neutral component purified purified necessary for binding necessary for binding required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) physical association physical association Fig 3C & Fig 3D tfrc-4 1 7 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. direct interaction direct interaction Fig 3E tf-tfrc-7 1 6 unspecified role unspecified role neutral component neutral component purified purified human Homo sapiens Human 7 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. direct interaction direct interaction Fig 3F a5k736_plavs-tf-4 1 8 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 6 unspecified role unspecified role neutral component neutral component purified purified human Homo sapiens Human 7 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. physical association physical association Fig 3E & Fig 3F a5k736_plavs-tf-9 5 6 unspecified role unspecified role neutral component neutral component purified purified human-serum Homo sapiens serum Serum 7 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P02786:p.Gly217del p.Gly217del mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain G . Tue Jun 30 17:51:41 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly217del' spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. 8 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) physical association physical association Fig 3C & Fig 4B tf-tfrc-8 5 6 unspecified role unspecified role neutral component neutral component purified purified human-serum Homo sapiens serum Serum 7 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. direct interaction direct interaction Fig 3C & Fig 3D