DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature 2017 imex curation Lolicato M., Arrigoni C., Mori T., Sekioka Y., Bryant C., Clark KA., Minor DL. daniel.minor@ucsf.edu 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation picpa Pichia pastoris (Yeast) Yeast Pichia pastoris x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Lolicato M., Arrigoni C., Mori T., Sekioka Y., Bryant C., Clark KA., Minor DL. daniel.minor@ucsf.edu Accepted 2018-JUL-30 AT 08:13 BST AT 08:13 BST by ORCHARD Nature 2017 imex curation kcnk2_mouse Potassium channel subfamily K member 2 Kcnk2 Outward rectifying potassium channel protein TREK-1 TREK-1 K(+) channel subunit Two pore potassium channel TPKC1 protein protein mouse Mus musculus Mouse MLASASRERPGYTAGVAAPDLLDPKSAAQNSKPRLSFSSKPTVLASRVESDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQTFIAQHACVNSTELDELIQQIVAAINAGIIPLGNSSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSVKRKLSAELAGNHNQELTPCRRTLSVNHLTSEREVLPPLLKAESIYLNGLTPHCAGEDIAVIENMK DIP protein P97438 original sequence version: 83 mint 8C298C01F5BDB61A kcnk2-1 1 2 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P97438:p.[Lys99Arg;Gln100Glu;Thr101Lys;Ile103Leu;Ala104Arg;Gln105Ala;Ala107Pro;Asn110Ser;Ser111Asp;Thr112Gln;Asn134Ala;Ser315Ala;Glu321Ala] K84R/Q85E/T86K/I88L/A89R/Q90A/A92P/N95S/S96D/T97Q/N119A/S300A/E306A mutation mutation certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain Q E certain certain sequence position certain certain certain sequence position certain T K certain certain sequence position certain certain certain sequence position certain I L certain certain sequence position certain certain certain sequence position certain A R certain certain sequence position certain certain certain sequence position certain Q A certain certain sequence position certain certain certain sequence position certain A P certain certain sequence position certain certain certain sequence position certain N S certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain T Q certain certain sequence position certain certain certain sequence position certain N A certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain E A Mon Jul 30 10:29:25 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys99Arg;Gln100Glu;Thr101Lys;Ile103Leu;Ala104Arg;Gln105Ala;Ala107Pro;Asn110Ser;Ser111Asp;Thr112Gln;Asn119Ala;Ser315Ala;Glu321Ala]' Tue Sep 04 16:38:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys99Arg;Gln100Glu;Thr101Lys;Ile103Leu;Ala104Arg;Gln105Ala;Ala107Pro;Asn110Ser;Ser111Asp;Thr112Gln;Asn119Ala;Ser315Ala;Glu321Ala]' Wed Sep 26 11:55:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys99Arg;Gln100Glu;Thr101Lys;Ile103Leu;Ala104Arg;Gln105Ala;Ala107Pro;Asn134Ser;Ser111Asp;Thr112Gln;Asn134Ala;Ser315Ala;Glu321Ala]' Tue Jun 30 16:47:41 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys99Arg;Gln100Glu;Thr101Lys;Ile103Leu;Ala104Arg;Gln105Ala;Ala107Pro;Asn110Ser;Ser111Asp;Thr112Gln;Asn134Ala;Ser315Ala;Glu321Ala]' picpa Pichia pastoris (Yeast) Yeast Pichia pastoris direct interaction direct interaction Extended Data Fig 1a, b