DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Nature 2016 imex curation Wang X., Feng J., Xue Y., Guan Z., Zhang D., Liu Z., Gong Z., Wang Q., Huang J., Tang C., Zou T., Yin P. Only protein-protein interactions trini Trichoplusia ni (Cabbage looper) Cabbage looper molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Wang X., Feng J., Xue Y., Guan Z., Zhang D., Liu Z., Gong Z., Wang Q., Huang J., Tang C., Zou T., Yin P. DIP original experiment: DIP-269101X Nature 2016 IMEx Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Nature 2016 imex curation Wang X., Feng J., Xue Y., Guan Z., Zhang D., Liu Z., Gong Z., Wang Q., Huang J., Tang C., Zou T., Yin P. Only protein-protein interactions trini Trichoplusia ni (Cabbage looper) Cabbage looper x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Wang X., Feng J., Xue Y., Guan Z., Zhang D., Liu Z., Gong Z., Wang Q., Huang J., Tang C., Zou T., Yin P. DIP original experiment: DIP-269103X Nature 2016 IMEx Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Nature 2016 imex curation Wang X., Feng J., Xue Y., Guan Z., Zhang D., Liu Z., Gong Z., Wang Q., Huang J., Tang C., Zou T., Yin P. Only protein-protein interactions trini Trichoplusia ni (Cabbage looper) Cabbage looper saxs x ray scattering saxs predetermined predetermined participant predetermined Wang X., Feng J., Xue Y., Guan Z., Zhang D., Liu Z., Gong Z., Wang Q., Huang J., Tang C., Zou T., Yin P. DIP original experiment: DIP-269102X Nature 2016 IMEx Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. met14_human N6-adenosine-methyltransferase non-catalytic subunit Methyltransferase-like protein 14 METTL14 KIAA1627 protein protein human Homo sapiens Human MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHRGGFPPR DIP protein Q9HCE5 original sequence version: 72 DIP protein Q9HCE5 original sequence version: 73 DIP protein Q9HCE5 original sequence version: 95 73A45B66BB76E241 q86u44-1 N6-adenosine-methyltransferase catalytic subunit N6-adenosine-methyltransferase 70 kDa subunit METTL3 MTA70 Methyltransferase-like protein 3 protein protein human Homo sapiens Human MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGGPKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRAEQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL DIP protein Q86U44-1 original sequence version: 95 DIP protein Q86U44-1 original sequence version: 117 mettl14-mettl3-11 2 4 unspecified role unspecified role unspecified role unspecified role Region 109-408 Region 109-408 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper 5 unspecified role unspecified role unspecified role unspecified role Region 369-580 Region 369-580 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction mettl14-mettl3-12 1 4 unspecified role unspecified role unspecified role unspecified role Region 109-408 Region 109-408 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper 5 unspecified role unspecified role unspecified role unspecified role Region 369-580 Region 369-580 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction mettl14-mettl3-13 3 4 unspecified role unspecified role unspecified role unspecified role Region 109-408 Region 109-408 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper 5 unspecified role unspecified role unspecified role unspecified role Region 369-580 Region 369-580 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction