DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration. Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration. Structure (London, England : 1993) 2016 imex curation Zhang H., Chang YC., Huang Q., Brennan ML., Wu J. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Zhang H., Chang YC., Huang Q., Brennan ML., Wu J. DIP original experiment: DIP-268527X Structure (London, England : 1993) 2016 IMEx Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration. Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration. Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration. Structure (London, England : 1993) 2016 imex curation Zhang H., Chang YC., Huang Q., Brennan ML., Wu J. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Zhang H., Chang YC., Huang Q., Brennan ML., Wu J. DIP original experiment: DIP-268526X Structure (London, England : 1993) 2016 IMEx Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration. tln1_mouse Talin-1 Tln1 Tln protein protein mouse Mus musculus Mouse MVALSLKISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDEGTGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFETLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDVLMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASAPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEIKAAARDGKLKPLPGETMEKCTQDLGNSTKAVSSAIAKLLGEIAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKASGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPASPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGDPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASQAKPAAVAAENEEIGAHIKHRVQELGHGCSALVTKAGALQCSPSDVYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGAETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAFHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPNPDLKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEDQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH DIP protein P26039 original sequence version: 109 DIP protein P26039 original sequence version: 114 DIP protein P26039 original sequence version: 151 DIP protein P26039 original sequence version: 165 DIP protein P26039 original sequence version: 136 78832388E2392B8E ab1ip_mouse Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Apbb1ip Prel1 APBB1-interacting protein 1 Proline-rich EVH1 ligand 1 Proline-rich protein 48 protein protein mouse Mus musculus Mouse MGESNEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPREEFNYTVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESSQNQDRFALLRASDGQGTASGGYGASAAAIDVSHHEEALPPPPVEPMLDLLPPPPPPPPPELLSKEEEEAKAKADKIKLALEKLKEAKVKKLVVKVHMDDSSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERVFEDHENVVEVLSDWTRDTENKVLFLEKEERYAVFKNPQNFYLDNKGKKENKETNEKMNAKNKEYLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGIQCKMKYKAPTDHCFVLKHPQIQKESQYIKYLCCDDARTLSQWVMGIRIAKYGKTLYDNYQRAVARAGLASRWTNLGTVGTPMPAQPSTVSSGLKTGTSQPNGQMPQAIPSAGPPLQEAQTQIETTKDEKQGLGNHSPGATRENHRPKSSLPPPPPPVRRSSDTCGSPALPSKVKGPGTCTFPHPPENFLPPPPPPPPEEDNSGLLPPPPPPPYLEEPPDFVPPPPPPAAVEDSALPPPPPPPPCLSQEITKSSPLPPKKPLVPPKRQENQGLPGAPGNSEQDFMSDLMKALQKKRGNIP DIP protein Q8R5A3 original sequence version: 103 DIP protein Q8R5A3 original sequence version: 116 mint Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion 39EB28E468C479C8 apbb1ip-tln1-7 2 4 unspecified role unspecified role bait bait Region 2-25 Region 2-25 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 3 unspecified role unspecified role prey prey Region 1357-1822 Region 1357-1822 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P26039:p.[Glu1794Tyr;Glu1797Tyr] E1794Y/E1797Y mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain E Y certain certain sequence position certain certain certain sequence position certain E Y This feature has been corrected as a result of our quality control procedures. The original label was 'E1794Y/E1797Y'. Wed May 02 19:09:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu1794tyr,glu1797tyr' Tue Jun 30 18:08:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Glu1794Tyr;Glu1797Tyr]' P26039:p.[Glu1794Tyr;Glu1797Tyr;Gln1801Tyr] E1794Y/E1797Y/Q1801Y mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain Q Y certain certain sequence position certain certain certain sequence position certain E Y certain certain sequence position certain certain certain sequence position certain E Y This feature has been corrected as a result of our quality control procedures. The original label was 'E1794Y/E1797Y/Q1801Y'. Wed May 02 14:55:47 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu1794tyr,glu1797tyr,gln1801tyr' Tue Jun 30 18:03:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Glu1794Tyr;Glu1797Tyr;Gln1801Tyr]' ecolx Escherichia coli direct interaction direct interaction apbb1ip-tln1-8 1 4 unspecified role unspecified role bait bait Region 2-25 Region 2-25 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 3 unspecified role unspecified role prey prey GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P26039:p.[Glu1794Tyr;Glu1797Tyr] E1794Y/E1797Y mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain E Y certain certain sequence position certain certain certain sequence position certain E Y This feature has been corrected as a result of our quality control procedures. The original label was 'E1794Y/E1797Y'. Wed May 02 17:50:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu1794tyr,glu1797tyr' Tue Jun 30 19:47:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Glu1794Tyr;Glu1797Tyr]' P26039:p.[Glu1794Tyr;Glu1797Tyr;Gln1801Tyr] E1794Y/E1797Y/Q1801Y mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain Q Y certain certain sequence position certain certain certain sequence position certain E Y certain certain sequence position certain certain certain sequence position certain E Y This feature has been corrected as a result of our quality control procedures. The original label was 'E1794Y/E1797Y/Q1801Y'. Wed May 02 16:47:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu1794tyr,glu1797tyr,gln1801tyr' Tue Jun 30 19:05:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Glu1794Tyr;Glu1797Tyr;Gln1801Tyr]' human Homo sapiens Human physical association physical association