DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Structure (London, England : 1993) 2016 imex curation Kouznetsova E., Kanno T., Karlberg T., Thorsell AG., Wisniewska M., Kursula P., Sjögren C., Schüler H. Only protein-protein interactions in vitro In vitro acetylase assay acetylase assay weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Kouznetsova E., Kanno T., Karlberg T., Thorsell AG., Wisniewska M., Kursula P., Sjögren C., Schüler H. DIP original experiment: DIP-268510X Structure (London, England : 1993) 2016 IMEx Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Structure (London, England : 1993) 2016 imex curation Kouznetsova E., Kanno T., Karlberg T., Thorsell AG., Wisniewska M., Kursula P., Sjögren C., Schüler H. Only protein-protein interactions ecolx Escherichia coli saxs x ray scattering saxs predetermined predetermined participant predetermined Kouznetsova E., Kanno T., Karlberg T., Thorsell AG., Wisniewska M., Kursula P., Sjögren C., Schüler H. DIP original experiment: DIP-268509X Structure (London, England : 1993) 2016 IMEx Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Structure (London, England : 1993) 2016 imex curation Kouznetsova E., Kanno T., Karlberg T., Thorsell AG., Wisniewska M., Kursula P., Sjögren C., Schüler H. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Kouznetsova E., Kanno T., Karlberg T., Thorsell AG., Wisniewska M., Kursula P., Sjögren C., Schüler H. DIP original experiment: DIP-268508X Structure (London, England : 1993) 2016 IMEx Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. q5fwf5-1 N-acetyltransferase ESCO1 ESCO1 EFO1 KIAA1911 CTF7 homolog 1 Establishment factor-like protein 1 Establishment of cohesion 1 homolog 1 protein protein human Homo sapiens Human MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST DIP protein Q5FWF5-1 original sequence version: 109 esco1-1 3 4 unspecified role unspecified role unspecified role unspecified role Region 654-836 Region 654-836 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction esco1-2 2 4 unspecified role unspecified role unspecified role unspecified role Region 654-836 Region 654-836 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction esco1-3 1 4 putative self putative self unspecified role unspecified role Region 654-836 Region 654-836 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q5FWF5-1:p.Gly768Asp G768D mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain G D This feature has been corrected as a result of our quality control procedures. The original label was 'G768D'. Wed May 02 18:06:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly768asp' Tue Jun 30 18:42:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly768Asp' Q5FWF5-1:p.Arg780Ala R780A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R780A'. Wed May 02 18:09:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg780ala' Tue Jun 30 18:31:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg780Ala' Q5FWF5-1:p.Glu789Ala E789A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain E A This feature has been corrected as a result of our quality control procedures. The original label was 'E789A'. Wed May 02 15:46:14 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu789ala' Tue Jun 30 20:19:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu789Ala' Q5FWF5-1:p.Lys803Ala K803A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain K A This feature has been corrected as a result of our quality control procedures. The original label was 'K803A'. Wed May 02 18:08:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys803ala' Tue Jun 30 17:40:57 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys803Ala' ac-K ac-K naclys N-acetylated L-lysine NAcLys modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain Resulting PTM ecolx Escherichia coli acetylation acetylation reaction acetylation true