DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS biology 2016 imex curation Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. DIP original experiment: DIP-268492X PLoS biology 2016 IMEx Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS biology 2016 imex curation Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. DIP original experiment: DIP-268490X PLoS biology 2016 IMEx Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS biology 2016 imex curation Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. DIP original experiment: DIP-268491X PLoS biology 2016 IMEx Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS biology 2016 imex curation Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. DIP original experiment: DIP-268486X PLoS biology 2016 IMEx Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS biology 2016 imex curation Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. Only protein-protein interactions in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. DIP original experiment: DIP-268494X PLoS biology 2016 IMEx Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS biology 2016 imex curation Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. DIP original experiment: DIP-268487X PLoS biology 2016 IMEx Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS biology 2016 imex curation Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. DIP original experiment: DIP-268489X PLoS biology 2016 IMEx Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS biology 2016 imex curation Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. DIP original experiment: DIP-268488X PLoS biology 2016 IMEx Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS biology 2016 imex curation Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Cheng IC., Chen BC., Shuai HH., Chien FC., Chen P., Hsieh TS. DIP original experiment: DIP-268493X PLoS biology 2016 IMEx Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. wdr4_human tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 WDR4 WD repeat-containing protein 4 Protein Wuho homolog protein protein human Homo sapiens Human MAGSVGLALCGQTLVVRGGSRFLATSIASSDDDSLFIYDCSAAEKKSQENKGEDAPLDQGSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSVRTVARRCTALTFIASEEKVLVADKSGDVYSFSVLEPHGCGRLELGHLSMLLDVAVSPDDRFILTADRDEKIRVSWAAAPHSIESFCLGHTEFVSRISVVPTQPGLLLSSSGDGTLRLWEYRSGRQLHCCHLASLQELVDPQAPQKFAASRIAFWCQENCVALLCDGTPVVYIFQLDARRQQLVYRQQLAFQHQVWDVAFEETQGLWVLQDCQEAPLVLYRPVGDQWQSVPESTVLKKVSGVLRGNWAMLEGSAGADASFSSLYKATFDNVTSYLKKKEERLQQQLEKKQRRRSPPPGPDGHAKKMRPGEATLSC DIP protein P57081 original sequence version: 129 394B11A2AFB1CADB pcna_human Proliferating cell nuclear antigen PCNA Cyclin protein protein human Homo sapiens Human MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS DIP protein P12004 original sequence version: 200 DIP protein P12004 original sequence version: 128 DIP protein P12004 original sequence version: 139 DIP protein P12004 original sequence version: 185 DIP protein P12004 original sequence version: 102 DIP protein P12004 original sequence version: 105 DIP protein P12004 original sequence version: 158 E6F08E7EDBC48B00 rs16_human 40S ribosomal protein S16 RPS16 Small ribosomal subunit protein uS9 protein protein human Homo sapiens Human MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR DIP protein P62249 original sequence version: 115 519BCFB91BB68A15 fen1_human Flap endonuclease 1 Flap structure-specific endonuclease 1 Maturation factor 1 DNase IV FEN1 RAD2 protein protein human Homo sapiens Human MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK DIP protein P39748 original sequence version: 106 DIP protein P39748 original sequence version: 112 DIP protein P39748 original sequence version: 160 5154F2F6E57592C5 trmb_human tRNA (guanine-N(7)-)-methyltransferase tRNA(m7G46)-methyltransferase Methyltransferase-like protein 1 tRNA (guanine(46)-N(7))-methyltransferase METTL1 C12orf1 mRNA (guanine-N(7)-)-methyltransferase miRNA (guanine-N(7)-)-methyltransferase protein protein human Homo sapiens Human MAAETRNVAGAEAPPPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPVLQAVTSQTSLPGH DIP protein Q9UBP6 original sequence version: 128 715AE85A18632892 h4_human Histone H4 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4 HIST2H4A HIST2H4B HIST4H4 protein protein human Homo sapiens Human MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG DIP protein P62805 original sequence version: 68 DIP protein P62805 original sequence version: 111 DIP protein P62805 original sequence version: 94 DIP protein P62805 original sequence version: 97 DIP protein P62805 original sequence version: 116 DIP protein P62805 original sequence version: 105 DIP protein P62805 original sequence version: 120 DIP protein P62805 original sequence version: 144 DIP protein P62805 original sequence version: 150 DIP protein P62805 original sequence version: 154 DIP protein P62805 original sequence version: 156 DIP protein P62805 original sequence version: 112 DIP protein P62805 original sequence version: 121 DIP protein P62805 original sequence version: 123 DIP protein P62805 original sequence version: 126 DIP protein P62805 original sequence version: 132 DIP protein P62805 original sequence version: 136 DIP protein P62805 original sequence version: 119 A9E5DFD3F8B97598 wdr4-fen1-1 4 12 unspecified role unspecified role prey prey human Homo sapiens Human 15 unspecified role unspecified role prey prey human Homo sapiens Human 14 unspecified role unspecified role prey prey human Homo sapiens Human 11 unspecified role unspecified role prey prey human Homo sapiens Human 13 unspecified role unspecified role prey prey human Homo sapiens Human 10 unspecified role unspecified role bait bait V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human association association wdr4-fen1-2 6 14 unspecified role unspecified role prey prey human Homo sapiens Human 11 unspecified role unspecified role prey prey human Homo sapiens Human 13 unspecified role unspecified role prey prey human Homo sapiens Human 10 unspecified role unspecified role bait bait V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human association association fen1-wdr4-1 7 13 unspecified role unspecified role bait bait human Homo sapiens Human 10 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association fen1-pcna-5 1 11 unspecified role unspecified role prey prey ecolx Escherichia coli 13 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range ecolx Escherichia coli direct interaction direct interaction wdr4-fen1-3 2 13 unspecified role unspecified role prey prey His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range ecolx Escherichia coli 10 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range ecolx Escherichia coli direct interaction direct interaction wdr4-fen1-4 8 13 unspecified role unspecified role prey prey human Homo sapiens Human 10 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association fen1-wdr4-2 3 13 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range ecolx Escherichia coli 10 unspecified role unspecified role prey prey GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range ecolx Escherichia coli direct interaction direct interaction wdr4-fen1-5 9 11 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range ecolx Escherichia coli 13 unspecified role unspecified role prey prey His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range ecolx Escherichia coli 10 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range ecolx Escherichia coli association association fen1-wdr4-3 5 13 unspecified role unspecified role unspecified role unspecified role ReAsH-label ReAsH-label fluorescent dye fluorescent dye label fluorescent dye c-term range C-terminal range c-term range c-term range C-terminal range c-term range ecolx Escherichia coli 10 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction