DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions in vitro In vitro bio-layer interferometry bio-layer interferometry bli bli predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267909X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267897X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267904X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267888X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267898X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267899X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions human Homo sapiens Human coip coimmunoprecipitation co-immunoprecipitation CoIp immunoprecipitation Co-IP co-immunoprecipitation CoIp immunoprecipitation Co-IP coip predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267901X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267894X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions in vitro In vitro deubiquitinase assay deubiquitinase assay deubiquitinase assay western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267893X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267891X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267890X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267895X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267896X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267884X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267900X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267908X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267892X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267885X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267886X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267887X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse coip coimmunoprecipitation co-immunoprecipitation CoIp immunoprecipitation Co-IP co-immunoprecipitation CoIp immunoprecipitation Co-IP coip predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267902X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267889X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267907X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267903X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267905X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2015 imex curation Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wertz IE., Newton K., Seshasayee D., Kusam S., Lam C., Zhang J., Popovych N., Helgason E., Schoeffler A., Jeet S., Ramamoorthi N., Kategaya L., Newman RJ., Horikawa K., Dugger D., Sandoval W., Mukund S., Zindal A., Martin F., Quan C., Tom J., Fairbrother WJ., Townsend M., Warming S., DeVoss J., Liu J., Dueber E., Caplazi P., Lee WP., Goodnow CC., Balazs M., Yu K., Kolumam G., Dixit VM. DIP original experiment: DIP-267906X Nature 2015 IMEx Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. ikkb_mouse Inhibitor of nuclear factor kappa-B kinase subunit beta I-kappa-B kinase 2 Nuclear factor NF-kappa-B inhibitor kinase beta Ikbkb Ikkb Serine/threonine protein kinase IKBKB protein protein mouse Mus musculus Mouse MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLESALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD DIP protein O88351 original sequence version: 126 DIP protein O88351 original sequence version: 73 DIP protein O88351 original sequence version: 99 DIP protein O88351 original sequence version: 114 DIP protein O88351 original sequence version: 149 FED962F095449C5E tnap3_human Tumor necrosis factor alpha-induced protein 3 Putative DNA-binding protein A20 Zinc finger protein A20 TNFAIP3 OTUD7C OTU domain-containing protein 7C protein protein human Homo sapiens Human MAEQVLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKTMHRYTLEMFRTCQFCPQFREIIHKALIDRNIQATLESQKKLNWCREVRKLVALKTNGDGNCLMHATSQYMWGVQDTDLVLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLIKMASTDTPMARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSHHFVPLVTLKDSGPEIRAVPLVNRDRGRFEDLKVHFLTDPENEMKEKLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENSEQGRREGHAQNPMEPSVPQLSLMDVKCETPNCPFFMSVNTQPLCHECSERRQKNQNKLPKLNSKPGPEGLPGMALGASRGEAYEPLAWNPEESTGGPHSAPPTAPSPFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHNARQLHASHAPDHTRHLDPGKCQACLQDVTRTFNGICSTCFKRTTAEASSSLSTSLPPSCHQRSKSDPSRLVRSPSPHSCHRAGNDAPAGCLSQAARTPGDRTGTSKCRKAGCVYFGTPENKGFCTLCFIEYRENKHFAAASGKVSPTASRFQNTIPCLGRECGTLGSTMFEGYCQKCFIEAQNQRFHEAKRTEEQLRSSQRRDVPRTTQSTSRPKCARASCKNILACRSEELCMECQHPNQRMGPGAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCNECFQFKQMYG DIP protein P21580 original sequence version: 129 DIP protein P21580 original sequence version: 166 320AEA97F58D4491 ikkb_human Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB IKKB I-kappa-B kinase 2 Nuclear factor NF-kappa-B inhibitor kinase beta Serine/threonine protein kinase IKBKB protein protein human Homo sapiens Human MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS DIP protein O14920 original sequence version: 89 DIP protein O14920 original sequence version: 100 DIP protein O14920 original sequence version: 121 DIP protein O14920 original sequence version: 126 DIP protein O14920 original sequence version: 136 DIP protein O14920 original sequence version: 128 DIP protein O14920-1 original sequence version: 151 DIP protein O14920 original sequence version: 142 DIP protein O14920 original sequence version: 159 DIP protein O14920 original sequence version: 93 DIP protein O14920 original sequence version: 124 DIP protein O14920-1 original sequence version: 178 DIP protein O14920 original sequence version: 85 F9CADF671AE9E14E casp8_mouse Caspase-8 Casp8 protein protein mouse Mus musculus Mouse MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP DIP protein O89110 original sequence version: 82 DIP protein O89110 original sequence version: 143 DIP protein O89110 original sequence version: 151 045268AE3DE5ED4F ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG cyld_mouse Ubiquitin carboxyl-terminal hydrolase CYLD Cyld Cyld1 Kiaa0849 Ubiquitin-specific-processing protease CYLD Deubiquitinating enzyme CYLD Ubiquitin thioesterase CYLD protein protein mouse Mus musculus Mouse MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRVPSTKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLAITNCEERLSLFRNRLRLSKGLQVDVGSPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGVYQGKQLFQCDEDCGVFVALDKLELIEDDDNGLESDFAGPGDTMQVEPPPLEINSRVSLKVGESTESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQLCSFASVESTILLHINDIIPDSVTQERRPPKLAFMSRGVGDKGSSSHNKPKVTGSTSDPGSRNRSELFYTLNGSSVDSQQSKSKNPWYIDEVAEDPAKSLTEMSSDFGHSSPPPQPPSMNSLSSENRFHSLPFSLTKMPNTNGSMAHSPLSLSVQSVMGELNSTPVQESPPLPISSGNAHGLEVGSLAEVKENPPFYGVIRWIGQPPGLSDVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKVQDCNFYQIFMEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK DIP protein Q80TQ2 original sequence version: 121 0AC0C7D4FF215A9C traf6_mouse TNF receptor-associated factor 6 RING-type E3 ubiquitin transferase TRAF6 Traf6 E3 ubiquitin-protein ligase TRAF6 protein protein mouse Mus musculus Mouse MSLLNCENSCGSSQSSSDCCAAMAASCSAAVKDDSVSGSASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIEDCPRRQVSCVNCAVSMAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPEDPNYEETIKQLESRLVRQDHQIRELTAKMETQSMYVGELKRTIRTLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEALIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVSTRFDMGGLRKEGFQPRSTDAGV DIP protein P70196 original sequence version: 139 DIP protein P70196 original sequence version: 128 DIP protein P70196 original sequence version: 144 DIP protein P70196 original sequence version: 83 DIP protein P70196 original sequence version: 98 DIP protein P70196 original sequence version: 104 DIP protein P70196 original sequence version: 112 DIP protein P70196 original sequence version: 163 F8389250425E4E2D traf2_mouse TNF receptor-associated factor 2 Traf2 E3 ubiquitin-protein ligase TRAF2 RING-type E3 ubiquitin transferase TRAF2 protein protein mouse Mus musculus Mouse MAAASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRLSEKEHHTEQECPKRSLSCQHCRAPCSHVDLEVHYEVCPKFPLTCDGCGKKKIPRETFQDHVRACSKCRVLCRFHTVGCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVTSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL DIP protein P39429 original sequence version: 90 DIP protein P39429 original sequence version: 130 DIP protein P39429 original sequence version: 135 DIP protein P39429 original sequence version: 166 043B391180365F10 ripk1_mouse Receptor-interacting serine/threonine-protein kinase 1 Cell death protein RIP Receptor-interacting protein 1 Ripk1 Rinp Rip protein protein mouse Mus musculus Mouse MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFAQQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLNSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS DIP protein Q60855 original sequence version: 85 DIP protein Q60855 original sequence version: 109 DIP protein Q60855 original sequence version: 152 DIP protein Q60855 original sequence version: 130 DIP protein Q60855 original sequence version: 84 DIP protein Q60855 original sequence version: 123 DIP protein Q60855 original sequence version: 158 ABB350B523879933 nemo_mouse NF-kappa-B essential modulator NF-kappa-B essential modifier Inhibitor of nuclear factor kappa-B kinase subunit gamma IkB kinase-associated protein 1 Ikbkg Nemo protein protein mouse Mus musculus Mouse MNKHPWKNQLSEMVQPSGGPAEDQDMLGEESSLGKPAMLHLPSEQGTPETLQRCLEENQELRDAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEKLDLRSQREQALKELEQLKKCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKDRQALEGRIRAVSEQVRQLESEREVLQQQHSVQVDQLRMQNQSVEAALRMERQAASEEKRKLAQLQAAYHQLFQDYDSHIKSSKGMQLEDLRQQLQQAEEALVAKQELIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERHAREKLVEKKEYLQEQLEQLQREFNKLKVGCHESARIEDMRKRHVETPQPPLLPAPAHHSFHLALSNQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE DIP protein O88522 original sequence version: 115 DIP protein O88522 original sequence version: 63 DIP protein O88522 original sequence version: 91 DIP protein O88522 original sequence version: 90 DIP protein O88522 original sequence version: 104 DIP protein O88522 original sequence version: 138 66C693C857A2D5E6 ripk3_mouse Receptor-interacting serine/threonine-protein kinase 3 Ripk3 Rip3 RIP-like protein kinase 3 Receptor-interacting protein 3 protein protein mouse Mus musculus Mouse MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPECPRPWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFDVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLSQHRSSGRNLSAREPSQRGTEMDCPRETMVSKMLDRLHLEEPSGPVPGKCPERQAQDTSVGPATPARTSSDPVAGTPQIPHTLPFRGTTPGPVFTETPGPHPQRNQGDGRHGTPWYPWTPPNPMTGPPALVFNNCSEVQIGNYNSLVAPPRTTASSSAKYDQAQFGRGRGWQPFHK DIP protein Q9QZL0 original sequence version: 88 DIP protein Q9QZL0 original sequence version: 125 DIP protein Q9QZL0 original sequence version: 133 31C5EEE77F55778B m3k7_mouse Mitogen-activated protein kinase kinase kinase 7 Map3k7 Tak1 Transforming growth factor-beta-activated kinase 1 protein protein mouse Mus musculus Mouse MSTASAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIVATAGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPARSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS DIP protein Q62073 original sequence version: 121 DIP protein Q62073 original sequence version: 108 DIP protein Q62073 original sequence version: 151 97C8F6F3C8E283EE tnfa_human Tumor necrosis factor TNF TNFA TNFSF2 TNF-alpha Tumor necrosis factor ligand superfamily member 2 Cachectin protein protein human Homo sapiens Human MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL DIP protein P01375 original sequence version: 198 DIP protein P01375 original sequence version: 151 DIP protein P01375 original sequence version: 156 DIP protein P01375 original sequence version: 186 DIP protein P01375 original sequence version: 201 DIP protein P01375 original sequence version: 174 DIP protein P01375 original sequence version: 211 3DF90F96C9031FFE tnap3_mouse Tumor necrosis factor alpha-induced protein 3 Putative DNA-binding protein A20 Zinc finger protein A20 Tnfaip3 Tnfip3 protein protein mouse Mus musculus Mouse MAEQLLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIYHFKTMHRYTLEMFRTCQFCPQFREIIHKALIDRSVQASLESQKKLNWCREVRKLVALKTNGDGNCLMHAACQYMWGVQDTDLVLRKALCSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLVKMASADTPAARSGLQYNSLEEIHIFVLSNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSQHFVPLVTLKDSGPELRAVPLVNRDRGRFEDLKVHFLTDPENEMKEKLLKEYLIVMEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENSDQARRAAHAQNPLEPSTPQLSLMDIKCETPNCPFFMSVNTQPLCHECSERRQKNQSKLPKLNSKLGPEGLPGVGLGSSNWSPEETAGGPHSAPPTAPSLFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHARQINASHTADPGKCQACLQDVTRTFNGICSTCFKRTTAEPSSSLTSSIPASCHQRSKSDPSQLIQSLTPHSCHRTGNVSPSGCLSQAARTPGDRAGTSKCRKAGCMYFGTPENKGFCTLCFIEYRENKQSVTASEKAGSPAPRFQNNVPCLGRECGTLGSTMFEGYCQKCFIEAQNQRFHEARRTEEQLRSSQHRDMPRTTQVASRLKCARASCKNILACRSEELCMECQHLSQRVGSVAHRGEPTPEEPPKQRCRAPACDHFGNAKCNGYCNECYQFKQMYG DIP protein Q60769 original sequence version: 92 DIP protein Q60769 original sequence version: 138 32349928908B3185 ikka_mouse Inhibitor of nuclear factor kappa-B kinase subunit alpha I-kappa-B kinase 1 Conserved helix-loop-helix ubiquitous kinase Nuclear factor NF-kappa-B inhibitor kinase alpha Chuk Ikka protein protein mouse Mus musculus Mouse MERPPGLRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSSKNRERWCHEIQIMKKLDHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKTIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLNWDPQQRGGPIDLTLKQPRCFALMDHILNLKIVHILNMTSAKIISFLLPCDESLHSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLEDQIMSLHTEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPPDHLYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGTVTPPVSAWLPPTLADREHPLTCVVTPQDGETLAQMIEENLNCLGHLSTIIREANEDQSSSLMSLDWSWLAE DIP protein Q60680 original sequence version: 82 DIP protein Q60680 original sequence version: 86 DIP protein Q60680 original sequence version: 113 DIP protein Q60680 original sequence version: 126 DIP protein Q60680 original sequence version: 158 3FEF5582AFF92233 rnf31_mouse E3 ubiquitin-protein ligase RNF31 HOIL-1-interacting protein Rnf31 Paul Putative Ariadne-like ubiquitin ligase RING finger protein 31 RING-type E3 ubiquitin transferase RNF31 protein protein mouse Mus musculus Mouse MPGDEERGFLAAREELASALRWDSAQVFPLEQLMPLLATSLPPAARYLQLDAGRLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRSVKFNNPVFRSTVDAVQGGRDVLRLYGYTEERPDGLSFPEGQEEPDEYQVAVVTLEVLLLRTELSLLLQNTHPRQNALDQLLRESVEDGMLQLSEFHPLLREIVPGPRPSAQGSTPGPCFLCGSAPGTLHCPACNQVSCPACDILFHGHPSRAHHLRQALPGSHQTASLSSSLPASSQPRPPSSSLALGDSSLSSPDPANACLPWHCLTCATLNEPWAVFCAVCSQPKGCKVPGIEGSHGTGGLEPEPARDQWACQSCTFENEAAAVLCAICERPRLAQPPSLVVDSHDAGVCQQSLKQEDPLLTAAQPQVWYCDHCTFCNSGPVWVCAMCNRTRDPIPTQPALQSYPSSLEKGRPKPGSSQHLGSSLPASCGDPEKQRQDKMRKEGLQLVSMIQEGETAGASPEEVFSALQYSGTEVPLQWLRSELSYVLEMVAELAGQQDPELGAFSCQEARKAWLDRHGNLDEAVEECVRARRRKVHELQSLGFGPKEGSLQALFQHGGDVARALTELQRQRLEPFHQRLWDRDPEPTPCWDGLDRQSLVRRLLAVYTLPSWGRAELALALLQETPRNYELLDVVEAVRHSQDRAFLRRLLAQECAVCGWALPRNRMQALISCECTICPECFRQHFTIALKEKHITDMVCPACGRPDLTDDAQLLSYFSTLDIQLRESLDPDAYALFHKKLTEAVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRTNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPDPNCKVKKSLHGHHPRDCLFYLRDWTAARLQKLLQDNNVMFNTEPPAGTRAVPGGGCRVMEQKEVHSGFRDEACGKETPPGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATIRYLHLAPQPADGEDLPAYQARLLQKLREEVPLGQSIARRRK DIP protein Q924T7 original sequence version: 69 DIP protein Q924T7 original sequence version: 113 C630572B8BDFC0AD traf5_mouse TNF receptor-associated factor 5 Traf5 protein protein mouse Mus musculus Mouse MAHSEEQAAVPCAFIRQNSGNSISLDFEPDTEYQFVEQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVDKEVIKPQEVFKDNCCKREVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCPNESCREAMLRKDVKEHLSAYCRFREEKCLYCKRDIVVTNLQDHEENSCPAYPVSCPNRCVQTIPRARVNEHLTVCPEAEQDCPFKHYGCTVKGKRGNLLEHERAALQDHMLLVLEKNYQLEQRISDLYQSLEQKESKIQQLAETVKKFEKELKQFTQMFGRNGTFLSNVQALTSHTDKSAWLEAQVRQLLQIVNQQPSRLDLRSLVDAVDSVKQRITQLEASDQRLVLLEGETSKHDAHINIHKAQLNKNEERFKQLEGACYSGKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVETFKADPNSSSFKRPDGEMNIASGCPRFVSHSTLENSKNTYIKDDTLFLKVAVDLTDLEDL DIP protein P70191 original sequence version: 132 48F64FB83BD587E5 tradd_mouse Tumor necrosis factor receptor type 1-associated DEATH domain protein Tradd TNFRSF1A-associated via death domain protein protein mouse Mus musculus Mouse MAAGQNGHEEWVGSAYLFLESAVDKVILSEAYTDPKKKVAIYKALQTALSESGDSSDVLQILKIHCSDPQLIVQLRFCGRVLCGRFLQAYREGALRTALQRCMAPALAQEALRLQLELRAGAEQLDSWLTDEERCLNYILAQKPDRLRDEELAELEDELCKLTCDCTGQGGAIQVASAGSKFPVSSPTEEKPLPAACQTFLFHGQLVVNRPLTLQDQQTFARSVGLKWRRVGRSLQRNCRALRDPALDSLAYEYERDGLYEQAFQLLRRFMQAEGRRATLQRLVEALEENELTSLAEDLLGQAEPDGGLA DIP protein Q3U0V2 original sequence version: 33 DIP protein Q3U0V2 original sequence version: 26 DIP protein Q3U0V2 original sequence version: 90 225F00D4022691BB tnr1a_mouse Tumor necrosis factor receptor superfamily member 1A p60 Tumor necrosis factor receptor 1 Tumor necrosis factor receptor type I p55 Tnfrsf1a Tnfr1 Tnfr-1 protein protein mouse Mus musculus Mouse MGLPTVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDSLCPQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSCKTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKETQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLVILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTSGFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVPAPTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQNGRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTTRLPR DIP protein P25118 original sequence version: 102 DIP protein P25118 original sequence version: 93 DIP protein P25118 original sequence version: 158 0710C2E8C3C2B6D9 fadd_mouse FAS-associated death domain protein FAS-associating death domain-containing protein Mediator of receptor induced toxicity Fadd Mort1 protein protein mouse Mus musculus Mouse MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLDLFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFDIVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAGLVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP DIP protein Q61160 original sequence version: 78 DIP protein Q61160 original sequence version: 97 DIP protein Q61160 original sequence version: 133 DIP protein Q61160 original sequence version: 139 4BC8D86B33A58783 ubiq_mouse Ubiquitin Rps27a Uba80 Ubcep1 Uba52 Ubcep2 Ubb Ubc protein protein mouse Mus musculus Mouse MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG C42A35397FFD9B52 hub-tnfaip3-1 16 31 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 28 unspecified role unspecified role unspecified role unspecified role Region 592-635 Region 592-635 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Region 758-790 Region 758-790 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P21580:p.[Cys624Ala;Cys627Ala] C624A/C627A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain C A certain certain sequence position certain certain certain sequence position certain C A This feature has been corrected as a result of our quality control procedures. The original label was 'C624A/C627A'. Wed May 02 19:16:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys624ala,cys627ala' Tue Jun 30 15:40:40 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Cys624Ala;Cys627Ala]' P21580:p.[Tyr614Ala;Phe615Ala] Y614A/F615A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain F A certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y614A/F615A'. Wed May 02 20:23:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr614ala,phe615ala' Tue Jun 30 16:15:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Tyr614Ala;Phe615Ala]' P21580:p.[Phe770Ala;Gly771Ala] F770A/G771A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain G A certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F770A/G771A'. Wed May 02 15:50:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe770ala,gly771ala' Tue Jun 30 16:25:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Phe770Ala;Gly771Ala]' ecolx Escherichia coli direct interaction direct interaction tnf-chuk-1 14 40 unspecified role unspecified role prey prey mouse Mus musculus Mouse 27 unspecified role unspecified role prey prey mouse Mus musculus Mouse 36 unspecified role unspecified role prey prey mouse Mus musculus Mouse 41 unspecified role unspecified role prey prey mouse Mus musculus Mouse 32 unspecified role unspecified role prey prey mouse Mus musculus Mouse 42 unspecified role unspecified role prey prey mouse Mus musculus Mouse 43 unspecified role unspecified role prey prey mouse Mus musculus Mouse 34 unspecified role unspecified role prey prey mouse Mus musculus Mouse 44 unspecified role unspecified role prey prey mouse Mus musculus Mouse 35 unspecified role unspecified role prey prey mouse Mus musculus Mouse 45 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse association association tnf-ikbkb-1 22 27 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association tnf-tnfaip3-1 15 40 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association fadd-ripk3-1 5 37 unspecified role unspecified role prey prey mouse Mus musculus Mouse 46 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association tnf-tradd-1 11 44 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association hub-tnfrsf1a-1 23 31 unspecified role unspecified role bait bait ecolx Escherichia coli 45 unspecified role unspecified role prey prey ecolx Escherichia coli physical association physical association fadd-casp8-15 6 30 unspecified role unspecified role prey prey mouse Mus musculus Mouse 46 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association mub-tnfrsf1a-1 10 47 unspecified role unspecified role bait bait mouse Mus musculus Mouse 45 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association mub-ripk1-1 21 47 unspecified role unspecified role bait bait mouse Mus musculus Mouse 35 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association tnfaip3-hub-1 1 31 unspecified role unspecified role prey prey ecolx Escherichia coli 28 unspecified role unspecified role bait bait Region 592-635 Region 592-635 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Region 758-790 Region 758-790 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P21580:p.[Cys624Ala;Cys627Ala] C624A/C627A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain C A certain certain sequence position certain certain certain sequence position certain C A This feature has been corrected as a result of our quality control procedures. The original label was 'C624A/C627A'. Wed May 02 20:10:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys624ala,cys627ala' Tue Jun 30 17:23:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Cys624Ala;Cys627Ala]' P21580:p.[Tyr614Ala;Phe615Ala] Y614A/F615A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain F A certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y614A/F615A'. Wed May 02 14:26:51 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr614ala,phe615ala' Tue Jun 30 17:19:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Tyr614Ala;Phe615Ala]' P21580:p.[Phe770Ala;Gly771Ala] F770A/G771A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain G A certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F770A/G771A'. Wed May 02 16:40:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe770ala,gly771ala' Tue Jun 30 17:54:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Phe770Ala;Gly771Ala]' ecolx Escherichia coli direct interaction direct interaction hub-tnfrsf1a-2 7 31 unspecified role unspecified role bait bait human Homo sapiens Human 45 unspecified role unspecified role prey prey P25118:p.Lys256Arg K256R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K256R'. Wed May 02 18:48:28 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys256arg' Tue Jun 30 19:54:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys256Arg' human Homo sapiens Human 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association tnf-chuk-2 18 27 unspecified role unspecified role prey prey mouse Mus musculus Mouse 36 unspecified role unspecified role prey prey mouse Mus musculus Mouse 41 unspecified role unspecified role prey prey mouse Mus musculus Mouse 32 unspecified role unspecified role prey prey mouse Mus musculus Mouse 42 unspecified role unspecified role prey prey mouse Mus musculus Mouse 43 unspecified role unspecified role prey prey mouse Mus musculus Mouse 35 unspecified role unspecified role prey prey mouse Mus musculus Mouse 45 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse association association mub-ripk1-2 17 35 unspecified role unspecified role prey prey mouse Mus musculus Mouse 47 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association ikbkb-tnfaip3-1 8 29 enzyme enzyme unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 28 enzyme target enzyme target substrate substrate unspecified role unspecified role pS381 pS381 opser O-phospho-L-serine (2S)-2-amino-3-(phosphonooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)propanoic acid ACT_SITE Phosphoserine intermediate MOD_RES Phosphoserine O-phospho-L-serine O-phosphonoserine O-phosphorylated L-serine O3-phosphoserine serine phosphate ester OPSer Phospho Phospho Seryl Phosphorylation phosphorylations modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain resulting-ptm resulting-ptm resulting ptm resulting-ptm ecolx Escherichia coli phosphorylation phosphorylation reaction phosphorylation hub-tnfaip3-2 9 31 enzyme target enzyme target substrate substrate unspecified role unspecified role K48Ub K48Ub ubiquitinylated lysine ubiquitinylated lysine certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 28 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli deubiquitination deubiquitination reaction deubiquitination tnf-casp8-1 12 30 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association tnf-casp8-2 24 37 unspecified role unspecified role prey prey mouse Mus musculus Mouse 30 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse association association tnf-tnfrsf1a-9 19 45 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association fadd-tnfrsf1a-1 13 46 unspecified role unspecified role bait bait mouse Mus musculus Mouse 45 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association mub-traf6-1 25 33 unspecified role unspecified role prey prey mouse Mus musculus Mouse 47 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association mub-ripk1-3 26 47 unspecified role unspecified role bait bait mouse Mus musculus Mouse 35 unspecified role unspecified role prey prey mouse Mus musculus Mouse 45 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association fadd-ripk1-11 3 47 unspecified role unspecified role bait bait mouse Mus musculus Mouse 35 unspecified role unspecified role prey prey mouse Mus musculus Mouse 46 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association tnf-ripk1-1 20 35 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association fadd-ripk1-12 2 35 unspecified role unspecified role prey prey mouse Mus musculus Mouse 46 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association tnf-map3k7-1 4 38 unspecified role unspecified role prey prey mouse Mus musculus Mouse 39 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association