DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Structure (London, England : 1993) 2015 imex curation Paracuellos P., Briggs DC., Carafoli F., Lončar T., Hohenester E. Only protein-protein interactions in vitro In vitro solid phase assay solid phase assay predetermined predetermined participant predetermined Paracuellos P., Briggs DC., Carafoli F., Lončar T., Hohenester E. DIP original experiment: DIP-267810X Structure (London, England : 1993) 2015 IMEx Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Structure (London, England : 1993) 2015 imex curation Paracuellos P., Briggs DC., Carafoli F., Lončar T., Hohenester E. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Paracuellos P., Briggs DC., Carafoli F., Lončar T., Hohenester E. DIP original experiment: DIP-267809X Structure (London, England : 1993) 2015 IMEx Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. mrc2_human C-type mannose receptor 2 MRC2 ENDO180 KIAA0709 UPARAP Macrophage mannose receptor 2 Endocytic receptor 180 Urokinase-type plasminogen activator receptor-associated protein CLEC13E C-type lectin domain family 13 member E protein protein human Homo sapiens Human MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGGQVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTTASLGMYECDREALNLRWHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPYVCKKKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVTYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDEVMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEEHFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDDDIRGCAVLDLASLQWVAMQCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFFEHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRFRWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQPPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQAFITASLPNVTFDLWIGLHASQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLLQKPLRWHDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVSEEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGSCPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQSYEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWRPGACTNITMGVVCKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQSIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE DIP protein Q9UBG0 original sequence version: 116 AAAA5286F91DF7E7 co1a1_rat Collagen alpha-1(I) chain Alpha-1 type I collagen Col1a1 protein protein rat Rattus norvegicus (Rat) Rat MFSFVDLRLLLLLGATALLTHGQEDIPEVSCIHNGLRVPNGETWKPDVCLICICHNGTAVCDGVLCKEDLDCPNPQKREGECCPFCPEEYVSPDAEVIGVEGPKGDPGPQGPRGPVGPPGQDGIPGQPGLPGPPGPPGPPGPPGLGGNFASQMSYGYDEKSAGVSVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDTGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGPPGSAGARGNDGAVGAAGPPGPTGPTGPPGFPGAAGAKGEAGPQGARGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPSGAPGPKGNSGEPGAPGNKGDTGAKGEPGPAGVQGPPGPAGEEGKRGARGEPGPSGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPAGPPGARGQAGVMGFPGPKGTAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGAPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGNNGAPGNDGAKGDTGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGETGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDTGVKGDAGPPGPAGPAGPPGPIGNVGAPGPKGSRGAAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPVGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGSPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGSPGAEGSPGRDGAPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKNGDRGETGPAGPAGPIGPAGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGSPGSPGEQGPSGASGPAGPRGPPGSAGSPGKDGLNGLPGPIGPPGPRGRTGDSGPAGPPGPPGPPGPPGPPSGGYDFSFLPQPPQEKSQDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNLDAIKVYCNMETGQTCVFPTQPSVPQKNWYISPNPKEKKHVWFGESMTDGFQFEYGSEGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKSLLLQGSNEIELRGEGNSRFTYSTLVDGCTSHTGTWGKTVIEYKTTKTSRLPIIDVAPLDIGAPDQEFGMDIGPACFV DIP protein P02454 original sequence version: 131 DIP protein P02454 original sequence version: 142 BCDDC40C3167AE59 col1a1-mrc2-1 2 4 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 3 unspecified role unspecified role prey prey Region 172-513 Region 172-513 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Q9UBG0:p.[Gln179Asn;Asn181Thr] Q179N/N181T mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain N T certain certain sequence position certain certain certain sequence position certain Q N This feature has been corrected as a result of our quality control procedures. The original label was 'Q179N/N181T'. Wed May 02 19:13:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln179asn,asn181thr' Tue Jun 30 18:34:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln179Asn;Asn181Thr]' Q9UBG0:p.Tyr193Ala Y193A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y193A'. Wed May 02 14:58:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr193ala' Tue Jun 30 18:34:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr193Ala' Q9UBG0:p.[Arg206Ala;Asp208Ala] R206A/D208A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain D A certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R206A/D208A'. Wed May 02 14:56:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg206ala,asp208ala' Tue Jun 30 18:53:34 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg206Ala;Asp208Ala]' Q9UBG0:p.Tyr219Ala Y219A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y219A'. Wed May 02 14:46:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr219ala' Tue Jun 30 20:05:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr219Ala' Q9UBG0:p.[Tyr292Asn;Ser294Thr] Y292N/S294T mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain S T certain certain sequence position certain certain certain sequence position certain Y N This feature has been corrected as a result of our quality control procedures. The original label was 'Y292N/S294T'. Wed May 02 16:48:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr292asn,ser294thr' Tue Jun 30 19:02:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Tyr292Asn;Ser294Thr]' human Homo sapiens Human direct interaction direct interaction col1a1-mrc2-2 1 4 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 3 unspecified role unspecified role prey prey Region 172-513 Region 172-513 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Q9UBG0:p.[Gln179Asn;Asn181Thr] Q179N/N181T mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain N T certain certain sequence position certain certain certain sequence position certain Q N This feature has been corrected as a result of our quality control procedures. The original label was 'Q179N/N181T'. Wed May 02 19:26:26 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln179asn,asn181thr' Tue Jun 30 15:48:57 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln179Asn;Asn181Thr]' Q9UBG0:p.Tyr193Ala Y193A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y193A'. Wed May 02 16:30:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr193ala' Tue Jun 30 16:11:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr193Ala' Q9UBG0:p.[Arg206Ala;Asp208Ala] R206A/D208A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain D A certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R206A/D208A'. Wed May 02 17:11:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg206ala,asp208ala' Tue Jun 30 15:35:55 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg206Ala;Asp208Ala]' Q9UBG0:p.Tyr219Ala Y219A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y219A'. Wed May 02 17:52:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr219ala' Tue Jun 30 18:43:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr219Ala' Q9UBG0:p.[Tyr292Asn;Ser294Thr] Y292N/S294T mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain S T certain certain sequence position certain certain certain sequence position certain Y N This feature has been corrected as a result of our quality control procedures. The original label was 'Y292N/S294T'. Wed May 02 14:50:32 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr292asn,ser294thr' Tue Jun 30 19:34:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Tyr292Asn;Ser294Thr]' human Homo sapiens Human direct interaction direct interaction