DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 2015 imex curation Kayagaki N., Stowe IB., Lee BL., O'Rourke K., Anderson K., Warming S., Cuellar T., Haley B., Roose-Girma M., Phung QT., Liu PS., Lill JR., Li H., Wu J., Kummerfeld S., Zhang J., Lee WP., Snipas SJ., Salvesen GS., Morris LX., Fitzgerald L., Zhang Y., Bertram EM., Goodnow CC., Dixit VM. Only protein-protein interactions in vitro In vitro protease assay protease assay weight by comassie molecular weight estimation by coomasie staining weight by comassie Kayagaki N., Stowe IB., Lee BL., O'Rourke K., Anderson K., Warming S., Cuellar T., Haley B., Roose-Girma M., Phung QT., Liu PS., Lill JR., Li H., Wu J., Kummerfeld S., Zhang J., Lee WP., Snipas SJ., Salvesen GS., Morris LX., Fitzgerald L., Zhang Y., Bertram EM., Goodnow CC., Dixit VM. DIP original experiment: DIP-267076X Nature 2015 IMEx Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. gsdmd_mouse Gasdermin-D Gsdmd Gasdermin domain-containing protein 1 Gsdmdc1 protein protein mouse Mus musculus Mouse MPSAFEKVVKNVIKEVSGSRGDLIPVDSLRNSTSFRPYCLLNRKFSSSRFWKPRYSCVNLSIKDILEPSAPEPEPECFGSFKVSDVVDGNIQGRVMLSGMGEGKISGGAAVSDSSSASMNVCILRVTQKTWETMQHERHLQQPENKILQQLRSRGDDLFVVTEVLQTKEEVQITEVHSQEGSGQFTLPGALCLKGEGKGHQSRKKMVTIPAGSILAFRVAQLLIGSKWDILLVSDEKQRTFEPSSGDRKAVGQRHHGLNVLAALCSIGKQLSLLSDGIDEEELIEAADFQGLYAEVKACSSELESLEMELRQQILVNIGKILQDQPSMEALEASLGQGLCSGGQVEPLDGPAGCILECLVLDSGELVPELAAPIFYLLGALAVLSETQQQLLAKALETTVLSKQLELVKHVLEQSTPWQEQSSVSLPTVLLGDCWDEKNPTWVLLEECGLRLQVESPQVHWEPTSLIPTSALYASLFLLSSLGQKPC DIP protein Q9D8T2 original sequence version: 85 casp4_mouse Caspase-4 Casp4 Casp11 Caspl Ich3 Caspase-11 Protease ICH-3 protein protein mouse Mus musculus Mouse MAENKHPDKPLKVLEQLGKEVLTEYLEKLVQSNVLKLKEEDKQKFNNAERSDKRWVFVDAMKKKHSKVGEMLLQTFFSVDPGSHHGEANLEMEEPEESLNTLKLCSPEEFTRLCREKTQEIYPIKEANGRTRKALIICNTEFKHLSLRYGANFDIIGMKGLLEDLGYDVVVKEELTAEGMESEMKDFAALSEHQTSDSTFLVLMSHGTLHGICGTMHSEKTPDVLQYDTIYQIFNNCHCPGLRDKPKVIIVQACRGGNSGEMWIRESSKPQLCRGVDLPRNMEADAVKLSHVEKDFIAFYSTTPHHLSYRDKTGGSYFITRLISCFRKHACSCHLFDIFLKVQQSFEKASIHSQMPTIDRATLTRYFYLFPGN DIP protein P70343 original sequence version: 132 casp4-gsdmdc1-1 1 2 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 2-487 Region 2-487 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper 3 enzyme enzyme unspecified role unspecified role Region 2-373 Region 2-373 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper protein cleavage protein cleavage