DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature cell biology 2015 imex curation Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. DIP original experiment: DIP-267983X Nature cell biology 2015 IMEx ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature cell biology 2015 imex curation Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. DIP original experiment: DIP-267985X Nature cell biology 2015 IMEx ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature cell biology 2015 imex curation Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. DIP original experiment: DIP-267988X Nature cell biology 2015 IMEx ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature cell biology 2015 imex curation Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. DIP original experiment: DIP-267989X Nature cell biology 2015 IMEx ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature cell biology 2015 imex curation Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. DIP original experiment: DIP-267986X Nature cell biology 2015 IMEx ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature cell biology 2015 imex curation Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. DIP original experiment: DIP-267987X Nature cell biology 2015 IMEx ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature cell biology 2015 imex curation Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhang J., Tripathi DN., Jing J., Alexander A., Kim J., Powell RT., Dere R., Tait-Mulder J., Lee JH., Paull TT., Pandita RK., Charaka VK., Pandita TK., Kastan MB., Walker CL. DIP original experiment: DIP-267984X Nature cell biology 2015 IMEx ATM functions at the peroxisome to induce pexophagy in response to ROS. atm_human Serine-protein kinase ATM ATM Ataxia telangiectasia mutated protein protein human Homo sapiens Human MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV DIP protein Q13315 original sequence version: 122 DIP protein Q13315 original sequence version: 189 DIP protein Q13315 original sequence version: 195 DIP protein Q13315 original sequence version: 166 DIP protein Q13315 original sequence version: 196 C0B4866E1E3199E2 ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG p50542-3 Peroxisomal targeting signal 1 receptor PEX5 PTS1-BP PXR1 Peroxin-5 Peroxisomal C-terminal targeting signal import receptor Peroxisome receptor 1 protein protein human Homo sapiens Human MAMRELVEAECGGANPLMKLAGHFTQDKALRQEGLRPGPWPPGAPASEAASKPLGVASEDELVAEFLQDQNAPLVSRAPQTFKMDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTATDRWYDEYHPEEDLQHTASDFVAKVDDPKLANSEFLKFVRQIGEGQVSLESGAGSGRAQAEQWAAEFIQQQGTSDAWVDQFTRPVNTSALDMEFERAKSAIELQAELEEMAKRDAEAHPWLSDYDDLTSATYDKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSTLLTMFGLPQ 9F3B705D888C484B sqstm_human Sequestosome-1 SQSTM1 ORCA OSIL Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa Ubiquitin-binding protein p62 EBI3-associated protein of 60 kDa protein protein human Homo sapiens Human MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL DIP protein Q13501 original sequence version: 139 DIP protein Q13501 original sequence version: 142 DIP protein Q13501 original sequence version: 163 DIP protein Q13501 original sequence version: 146 DIP protein Q13501 original sequence version: 162 DIP protein Q13501 original sequence version: 155 DIP protein Q13501 original sequence version: 140 462D94C171F337CD p50542-1 Peroxisomal targeting signal 1 receptor PEX5 PXR1 PTS1-BP Peroxin-5 Peroxisomal C-terminal targeting signal import receptor Peroxisome receptor 1 protein protein human Homo sapiens Human MAMRELVEAECGGANPLMKLAGHFTQDKALRQEGLRPGPWPPGAPASEAASKPLGVASEDELVAEFLQDQNAPLVSRAPQTFKMDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTATDRWYDEYHPEEDLQHTASDFVAKVDDPKLANSEFLKFVRQIGEGQVSLESGAGSGRAQAEQWAAEFIQQQGTSDAWVDQFTRPVNTSALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSATYDKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSTLLTMFGLPQ DIP protein P50542-1 original sequence version: 131 DIP protein P50542 original sequence version: 165 ub-pex5-1 2 9 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal human Homo sapiens Human 10 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P50542-3:p.Lys209Arg K209R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K209R'. Wed May 02 14:42:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys209arg' Tue Jun 30 18:21:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys209Arg' human Homo sapiens Human physical association physical association pex5-atm-1 1 8 unspecified role unspecified role prey prey human Homo sapiens Human 12 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association sqstm1-pex5-1 3 11 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 10 unspecified role unspecified role prey prey P50542-3:p.Lys209Arg K209R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K209R'. Wed May 02 18:19:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys209arg' Tue Jun 30 17:05:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys209Arg' Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association pex5-atm-2 7 8 unspecified role unspecified role prey prey Q13315:p.Arg3047Gln R3047Q mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R Q This feature has been corrected as a result of our quality control procedures. The original label was 'R3047Q'. Wed May 02 16:59:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg3047gln' Tue Jun 30 19:54:22 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg3047Gln' Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 10 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association pex5-ub-1 5 9 unspecified role unspecified role prey prey human Homo sapiens Human 12 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association pex5-sqstm1-1 4 11 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 10 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P50542-3:p.Lys209Arg K209R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K209R'. Wed May 02 15:28:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys209arg' Tue Jun 30 15:39:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys209Arg' human Homo sapiens Human physical association physical association pex5-sqstm1-2 6 11 unspecified role unspecified role prey prey human Homo sapiens Human 12 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association