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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Glycine receptor mechanism elucidated by electron cryo-microscopy.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="26344198" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/nature14853" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16175112" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-24908" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Glycine receptor mechanism elucidated by electron cryo-microscopy.</attribute>
            <attribute name="journal" nameAc="MI:0885">Nature</attribute>
            <attribute name="publication year" nameAc="MI:0886">2015</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Du J.,  Lü W.,  Wu S.,  Cheng Y.,  Gouaux E.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-24908" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="3JAF" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="3JAE" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-267069X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="3JAD" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/nature14853" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="7108">
            <names>
              <shortLabel>spofr</shortLabel>
              <fullName>Spodoptera frugiperda (Fall armyworm)</fullName>
              <alias type="synonym" typeAc="MI:1041">Fall armyworm</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>3d-em</shortLabel>
            <fullName>3D electron microscopy</fullName>
            <alias type="synonym" typeAc="MI:1041">3D-EM</alias>
            <alias type="synonym" typeAc="MI:1041">electron tomog</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0410" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608522" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="12160704" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Du J., Lü W., Wu S., Cheng Y., Gouaux E.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-267069X</attribute>
          <attribute name="journal" nameAc="MI:0885">Nature</attribute>
          <attribute name="publication year" nameAc="MI:0886">2015</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Glycine receptor mechanism elucidated by electron cryo-microscopy.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>glra1_danre</shortLabel>
          <fullName>Glycine receptor subunit alphaZ1</fullName>
          <alias type="gene name" typeAc="MI:0301">glra1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="O93430" version="120" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDARP00000003268" version="SP_159" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16175134" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDARG00000012019" version="SP_159" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDART00000005499" version="SP_159" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004888" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006811" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007218" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007268" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007417" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016594" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016933" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016934" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0022824" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030425" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030594" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034220" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034707" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042391" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043005" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043200" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043204" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045202" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045211" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045664" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050877" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060012" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071230" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071294" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071361" version="SP_159"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902476" version="SP_159"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006028" version="SP_159"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006029" version="SP_159"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006201" version="SP_159"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006202" version="SP_159"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008127" version="SP_159"/>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018000" version="SP_159"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036719" version="SP_159"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036734" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3JAD" version="SP_159"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PLS" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PLT" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PLU" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PLV" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PLW" version="SP_159"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PLY" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PLZ" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PM0" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PM1" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PM2" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PM3" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PM4" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PM5" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PM6" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PXD" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UBS" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UBT" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UD3" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VM0" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VM2" version="SP_159"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VM3" version="SP_159"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-DRE-112314" version="SP_159"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_571477.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-61772N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="7955">
          <names>
            <shortLabel>danre</shortLabel>
            <fullName>Danio rerio (Zebrafish)</fullName>
            <alias type="synonym" typeAc="MI:1041">Brachydanio rerio</alias>
            <alias type="synonym" typeAc="MI:1041">Zebrafish</alias>
          </names>
        </organism>
        <sequence>MFALGIYLWETIVFFSLAASQQAAARKAASPMPPSEFLDKLMGKVSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRISKNGNVLYSIRITLVLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFIARQHKELLRFQRRRRHLKEDEAGDGRFSFAAYGMGPACLQAKDGMAIKGNNNNAPTSTNPPEKTVEEMRKLFISRAKRIDTVSRVAFPLVFLIFNIFYWITYKIIRSEDIHKQ</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein O93430 original sequence version: 120</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-24908-1">
        <names>
          <shortLabel>glra1-4</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-199906E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16175176" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-24908-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
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                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="5">
                <names>
                  <shortLabel>Region 34-333/401-434</shortLabel>
                  <fullName>Region 34-333/401-434</fullName>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-16175181" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>sufficient to bind</shortLabel>
                    <fullName>sufficient binding region</fullName>
                    <alias type="synonym" typeAc="MI:1041">sufficient to bind</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
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                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
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                    </startStatus>
                    <begin position="401"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
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                      </xref>
                    </endStatus>
                    <end position="434"/>
                  </featureRange>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
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                      </xref>
                    </startStatus>
                    <begin position="34"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
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                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="333"/>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="7108">
                <names>
                  <shortLabel>spofr</shortLabel>
                  <fullName>Spodoptera frugiperda (Fall armyworm)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Fall armyworm</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>