UniProt UniProt http://www.uniprot.org Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nature medicine 2015 imex curation Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. gshi@rics.bwh.harvard.edu 21-Mar-2017: Contacted by IntAct-Help. Only protein-protein interactions mouse-arterial_smooth_muscle mouse Mouse arterial _smooth _muscle fluorescence imaging fluorescence microscopy fluorescence imaging immunostaining immunostaining Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. Atherosclerotic lesions from Apoe−/− mice gshi@rics.bwh.harvard.edu Accepted 2017-JAN-25 AT 13:48 GMT AT 13:48 GMT by MGT Nature medicine 2015 imex curation Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nature medicine 2015 imex curation Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. gshi@rics.bwh.harvard.edu 21-Mar-2017: Contacted by IntAct-Help. Only protein-protein interactions mouse-macrophage Mus musculus macrophage macrophage Macrophage anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. Apoe−/− mice gshi@rics.bwh.harvard.edu Accepted 2017-JAN-25 AT 13:48 GMT AT 13:48 GMT by MGT Nature medicine 2015 imex curation Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nature medicine 2015 imex curation Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. gshi@rics.bwh.harvard.edu 21-Mar-2017: Contacted by IntAct-Help. Only protein-protein interactions mouse-macrophage Mus musculus macrophage macrophage Macrophage fluorescence imaging fluorescence microscopy fluorescence imaging immunostaining immunostaining Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. atherosclerotic lesions from Apoe−/− mice gshi@rics.bwh.harvard.edu Accepted 2017-JAN-25 AT 13:48 GMT AT 13:48 GMT by MGT Nature medicine 2015 imex curation Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nature medicine 2015 imex curation Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. gshi@rics.bwh.harvard.edu 21-Mar-2017: Contacted by IntAct-Help. Only protein-protein interactions mouse-endothelium Mus musculus endothelium Endothelial cells [endothelium] anti bait coip anti bait coimmunoprecipitation anti bait coip ms participant Identification by mass spectrometry ms participant Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. Apoe−/−Il18r−/− mice gshi@rics.bwh.harvard.edu Accepted 2017-JAN-25 AT 13:48 GMT AT 13:48 GMT by MGT Nature medicine 2015 imex curation Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nature medicine 2015 imex curation Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. gshi@rics.bwh.harvard.edu 21-Mar-2017: Contacted by IntAct-Help. Only protein-protein interactions mouse-endothelium Mus musculus endothelium Endothelial cells [endothelium] fluorescence imaging fluorescence microscopy fluorescence imaging immunostaining immunostaining Wang J., Sun C., Gerdes N., Liu C., Liao M., Liu J., Shi MA., He A., Zhou Y., Sukhova GK., Chen H., Cheng XW., Kuzuya M., Murohara T., Zhang J., Cheng X., Jiang M., Shull GE., Rogers S., Yang CL., Ke Q., Jelen S., Bindels R., Ellison DH., Jarolim P., Libby P., Shi GP. atherosclerotic lesions from Apoe−/− mice gshi@rics.bwh.harvard.edu Accepted 2017-JAN-25 AT 13:48 GMT AT 13:48 GMT by MGT Nature medicine 2015 imex curation s12a3_mouse Solute carrier family 12 member 3 Slc12a3 Tsc Thiazide-sensitive sodium-chloride cotransporter Na-Cl symporter Ncc protein protein mouse Mus musculus Mouse MAELPVTELPGDALCSGRFTISTLMGGDEPPPAACDSSQPSHLTHGSTLYMRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDGRQGRELTDGLVEDETGTNSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGTPIVDPINDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPASEDKASKGFYSYHGDIFVQNLVPDWRGIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDVNDTMTPGPGPCEGLACGYGWNFTECSQQRSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNREPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIGPGKQRVPELRLIASGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKRNWQSAHPATVEDYIGVLHDAFDFNYGVCVMRMREGLNVSEALQTHTTPEALIQEEQASTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLHRKKRWGKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPQAEHTKRFEDMIAPFRLNDGFKDEATVTEMRRDCPWKISDEEINKNRIKSLRQVRLSEILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLETLSQDLRPPVLLIRGNQENVLTFYCQ mint Electrically silent transporter system. Mediates sodium and chloride reabsorption 61CB02500C9093B9 il18r_mouse Interleukin-18 receptor 1 Interleukin-18 receptor alpha CD218 antigen-like family member A IL1 receptor-related protein Il18r1 protein protein mouse Mus musculus Mouse MHHEELILTLCILIVKSASKSCIHRSQIHVVEGEPFYLKPCGISAPVHRNETATMRWFKGSASHEYRELNNRSSPRVTFHDHTLEFWPVEMEDEGTYISQVGNDRRNWTLNVTKRNKHSCFSDKLVTSRDVEVNKSLHITCKNPNYEELIQDTWLYKNCKEISKTPRILKDAEFGDEGYYSCVFSVHHNGTRYNITKTVNITVIEGRSKVTPAILGPKCEKVGVELGKDVELNCSASLNKDDLFYWSIRKEDSSDPNVQEDRKETTTWISEGKLHASKILRFQKITENYLNVLYNCTVANEEAIDTKSFVLVRKEIPDIPGHVFTGGVTVLVLASVAAVCIVILCVIYKVDLVLFYRRIAERDETLTDGKTYDAFVSYLKECHPENKEEYTFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNGARRELESGLHEALVERKIKIILIEFTPASNITFLPPSLKLLKSYRVLKWRADSPSMNSRFWKNLVYLMPAKAVKPWREESEARSVLSAP B119FEA403355458 il18r1-slc12a3-1 3 6 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component colocalization colocalization 2D il18r1-slc12a3-2 5 6 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component colocalization colocalization 2D il18r1-slc12a3-3 1 6 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component colocalization colocalization 2D Atheroslerotic lesions tissue has been analyzed il18r1-slc12a3-4 2 6 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait physical association physical association 2g IL18 il18r1-slc12a3-5 4 6 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait physical association physical association 1D