DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Science (New York, N.Y.) 2015 imex curation Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. DIP original experiment: DIP-265349X Science (New York, N.Y.) 2015 IMEx Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Science (New York, N.Y.) 2015 imex curation Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. DIP original experiment: DIP-265350X Science (New York, N.Y.) 2015 IMEx Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Science (New York, N.Y.) 2015 imex curation Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. DIP original experiment: DIP-265348X Science (New York, N.Y.) 2015 IMEx Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. cld19_mouse Claudin-19 Cldn19 protein protein mouse Mus musculus Mouse MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPTAKSRVAISGGALFLLAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAMLGGSFLCCTCPEPERANSIPQPYRSGPSTAAREPVVKLPASVKGPLGV DIP protein Q9ET38 original sequence version: 98 mint Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity 4282BE63C4D8BCD2 eltb_clopf Heat-labile enterotoxin B chain cpe protein protein clostridium perfring Clostridium perfringens MLSNNLNPMVFENAKEVFLISEDLKTPINITNSNSNLSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF DIP protein P01558 original sequence version: 82 cld3_mouse Claudin-3 Cldn3 Cpetr2 Clostridium perfringens enterotoxin receptor 2 protein protein mouse Mus musculus Mouse MSMGLEITGTSLAVLGWLCTIVCCALPMWRVSAFIGSSIITAQITWEGLWMNCVVQSTGQMQCKMYDSLLALPQDLQAARALIVVSILLAAFGLLVALVGAQCTNCVQDETAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPLVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPRDKYAPTKILYSAPRSTGPGTGTGTAYDRKDYV DIP protein Q9Z0G9 original sequence version: 115 mint Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity 62F67810D9B9BD37 cldn19-cpe-1 3 4 unspecified role unspecified role unspecified role unspecified role Q9ET38:p.Asn150Leu N150L/D/K/Q/S mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain N L Wed May 02 15:11:50 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn150leu' Tue Jun 30 18:41:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn150Leu' Q9ET38:p.Ile41Ser I41S/V mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain I S Wed May 02 17:48:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile41ser' Tue Jun 30 19:08:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile41Ser' Q9ET38:p.Ile40Ser I40S/V/L mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain I S Wed May 02 14:50:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile40ser' Tue Jun 30 20:23:04 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile40Ser' Q9ET38:p.Ala39Arg A39R/S mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain A R Wed May 02 15:06:55 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala39arg' Tue Jun 30 19:51:03 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala39Arg' Q9ET38:p.Tyr35Ser Y35S mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain Y S This feature has been corrected as a result of our quality control procedures. The original label was 'Y35S'. Wed May 02 18:04:34 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr35ser' Tue Jun 30 17:49:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr35Ser' Q9ET38:p.Tyr159Ser Y159S/F mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain Y S Wed May 02 19:59:50 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr159ser' Tue Jun 30 19:28:46 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr159Ser' Q9ET38:p.Pro154Asp P154D mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain P D This feature has been corrected as a result of our quality control procedures. The original label was 'P154D'. Wed May 02 16:19:50 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro154asp' Tue Jun 30 17:23:45 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro154Asp' Q9ET38:p.Asn156Gly N156G mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain N G This feature has been corrected as a result of our quality control procedures. The original label was 'N156G'. Wed May 02 15:41:59 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn156gly' Tue Jun 30 16:48:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn156Gly' Q9ET38:p.Ser152Asp S152D mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain S D This feature has been corrected as a result of our quality control procedures. The original label was 'S152D'. Wed May 02 17:36:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser152asp' Tue Jun 30 17:16:09 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser152Asp' Q9ET38:p.Thr153Tyr T153Y mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain T Y This feature has been corrected as a result of our quality control procedures. The original label was 'T153Y'. Wed May 02 15:34:56 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr153tyr' Tue Jun 30 18:24:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr153Tyr' Q9ET38:p.Pro151Gly P151G mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain P G This feature has been corrected as a result of our quality control procedures. The original label was 'P151G'. Wed May 02 17:28:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro151gly' Tue Jun 30 18:59:37 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro151Gly' Q9ET38:p.Ile40Ala I40A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain I A This feature has been corrected as a result of our quality control procedures. The original label was 'I40A'. Wed May 02 18:12:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile40ala' Tue Jun 30 15:46:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile40Ala' Q9ET38:p.Ile41Ala I41A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain I A This feature has been corrected as a result of our quality control procedures. The original label was 'I41A'. Wed May 02 15:10:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile41ala' Tue Jun 30 18:43:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile41Ala' Q9ET38:p.Pro154Ala P154A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P154A'. Wed May 02 15:53:18 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro154ala' Tue Jun 30 19:33:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro154Ala' Q9ET38:p.Asn150Ala N150A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain N A This feature has been corrected as a result of our quality control procedures. The original label was 'N150A'. Wed May 02 19:41:26 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn150ala' Tue Jun 30 19:17:32 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn150Ala' Q9ET38:p.Pro151Ala P151A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P151A'. Wed May 02 15:32:20 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro151ala' Tue Jun 30 18:02:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro151Ala' Q9ET38:p.Ala39Ser mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain A S Wed May 02 19:20:48 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala39ser' Tue Jun 30 17:56:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala39Ser' Q9ET38:p.Asn150Asp mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain N D Wed May 02 18:55:16 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn150asp' Tue Jun 30 17:32:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn150Asp' Q9ET38:p.Asn150Lys mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain N K Wed May 02 16:00:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn150lys' Tue Jun 30 19:03:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn150Lys' Q9ET38:p.Asn150Gln mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain N Q Wed May 02 19:22:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn150gln' Tue Jun 30 16:08:34 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn150Gln' Q9ET38:p.Asn150Ser mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain N S Wed May 02 14:56:50 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn150ser' Tue Jun 30 20:25:27 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn150Ser' Q9ET38:p.Ile41Val mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain I V Wed May 02 15:46:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile41val' Tue Jun 30 18:33:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile41Val' Q9ET38:p.Ile40Val mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain I V Wed May 02 20:23:05 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile40val' Tue Jun 30 16:19:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile40Val' Q9ET38:p.Ile40Leu mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain I L Wed May 02 15:35:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile40leu' Tue Jun 30 15:42:02 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile40Leu' Q9ET38:p.Tyr159Phe mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain Y F Wed May 02 15:37:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr159phe' Tue Jun 30 15:46:03 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr159Phe' spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 5 unspecified role unspecified role unspecified role unspecified role Region 194-319 Region 194-319 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cldn3-cpe-1 1 6 unspecified role unspecified role unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 5 unspecified role unspecified role unspecified role unspecified role Region 194-319 Region 194-319 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cldn19-cpe-2 2 4 unspecified role unspecified role unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 5 unspecified role unspecified role unspecified role unspecified role Region 203-319 Region 203-319 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction