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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="25143115" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/nature13669" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16118354" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-23139" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.</attribute>
            <attribute name="journal" nameAc="MI:0885">Nature</attribute>
            <attribute name="publication year" nameAc="MI:0886">2014</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Althoff T.,  Hibbs RE.,  Banerjee S.,  Gouaux E.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-23139" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="4TNV" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-262080X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="4TNW" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="25143115" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/nature13669" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="7108">
            <names>
              <shortLabel>spofr</shortLabel>
              <fullName>Spodoptera frugiperda (Fall armyworm)</fullName>
              <alias type="synonym" typeAc="MI:1041">Fall armyworm</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Althoff T., Hibbs RE., Banerjee S., Gouaux E.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-262080X</attribute>
          <attribute name="journal" nameAc="MI:0885">Nature</attribute>
          <attribute name="publication year" nameAc="MI:0886">2014</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>glucl_caeel</shortLabel>
          <fullName>Glutamate-gated chloride channel alpha</fullName>
          <alias type="gene name" typeAc="MI:0301">glc-1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Avermectin-sensitive glutamate-gated chloride channel GluCl alpha</alias>
          <alias type="gene name synonym" typeAc="MI:0302">GluCl alpha</alias>
          <alias type="orf name" typeAc="MI:0306">F11A5.10</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="G5EBR3" version="25" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblmetazoa" id="F11A5.10.1" version="SP_69" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblmetazoa" id="F11A5.10.2" version="SP_69" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16006417" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblmetazoa" id="F11A5.10.1" version="SP_69" refType="transcript"/>
          <secondaryRef db="ensemblmetazoa" id="F11A5.10.2" version="SP_69" refType="transcript"/>
          <secondaryRef db="ensemblmetazoa" id="WBGene00001591" version="SP_69" refType="gene"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004888" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007268" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008068" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016595" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030594" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031987" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034220" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042391" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043005" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045202" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045211" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050877" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051259" version="SP_69"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902476" version="SP_69"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_507090.1"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3RHW"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3RI5"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3RIA"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3RIF"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4TNV"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4TNW"/>
          <secondaryRef db="wormbase" dbAc="MI:0487" id="F11A5.10"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006028"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006029"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018000"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR044721" version="SP_69"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015680"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-CEL-112314"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036719"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036734"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="6239">
          <names>
            <shortLabel>caeel</shortLabel>
            <fullName>Caenorhabditis elegans</fullName>
          </names>
        </organism>
        <sequence>MATWIVGKLIIASLILGIQAQQARTKSQDIFEDDNDNGTTTLESLARLTSPIHIPIEQPQTSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANKQGVERKARTEREKAEIPLLQNLHNDVPTKVFNQEEKVRTVPLNRRQMNSFLNLLETKTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGQQNVLF</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein G5EBR3 original sequence version: 25</attribute>
          <attribute name="remark-internal">DIP protein G5EBR3 original sequence version: 7</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-23139-1">
        <names>
          <shortLabel>glc_1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-187243E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16118375" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-23139-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="7108">
                <names>
                  <shortLabel>spofr</shortLabel>
                  <fullName>Spodoptera frugiperda (Fall armyworm)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Fall armyworm</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>