DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science (New York, N.Y.) 2014 imex curation Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. DIP original experiment: DIP-264655X Science (New York, N.Y.) 2014 IMEx Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science (New York, N.Y.) 2014 imex curation Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. DIP original experiment: DIP-264654X Science (New York, N.Y.) 2014 IMEx Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science (New York, N.Y.) 2014 imex curation Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. Only protein-protein interactions human Homo sapiens Human fret fluorescent resonance energy transfer FRET RET FRET analysis FRET RET FRET analysis fret predetermined predetermined participant predetermined Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. DIP original experiment: DIP-264652X Science (New York, N.Y.) 2014 IMEx Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science (New York, N.Y.) 2014 imex curation Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. DIP original experiment: DIP-264653X Science (New York, N.Y.) 2014 IMEx Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science (New York, N.Y.) 2014 imex curation Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. Only protein-protein interactions human Homo sapiens Human fret fluorescent resonance energy transfer FRET RET FRET analysis FRET RET FRET analysis fret predetermined predetermined participant predetermined Lucifora J., Xia Y., Reisinger F., Zhang K., Stadler D., Cheng X., Sprinzl MF., Koppensteiner H., Makowska Z., Volz T., Remouchamps C., Chou WM., Thasler WE., Hüser N., Durantel D., Liang TJ., Münk C., Heim MH., Browning JL., Dejardin E., Dandri M., Schindler M., Heikenwalder M., Protzer U. DIP original experiment: DIP-264651X Science (New York, N.Y.) 2014 IMEx Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. abc3g_human DNA dC->dU-editing enzyme APOBEC-3G APOBEC-related cytidine deaminase APOBEC-related protein 9 CEM-15 APOBEC3G Deoxycytidine deaminase MDS019 protein protein human Homo sapiens Human MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN DIP protein Q9HC16 original sequence version: 140 DIP protein Q9HC16 original sequence version: 68 DIP protein Q9HC16-1 original sequence version: 88 DIP protein Q9HC16-1 original sequence version: 84 DIP protein Q9HC16 original sequence version: 138 DIP protein Q9HC16-1 original sequence version: 68 60525DC3B7D903D6 q784z8_hbv Capsid protein C core preC HBVgp4 c Core antigen Core protein HBcAg p21.5 protein protein hbv Hepatitis B virus (HBV) HBV MDIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC DIP protein Q784Z8 original sequence version: 109 ED2DA1DB07FB596D abc3a_human DNA dC->dU-editing enzyme APOBEC-3A APOBEC3A Phorbolin-1 protein protein human Homo sapiens Human MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN DIP protein P31941 original sequence version: 134 DIP protein P31941-1 original sequence version: 135 42E99E0D7DF7AA14 apobec3a-c-1 1 8 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 7 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association apobec3g-c-1 5 7 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept Region 149-183 Region 149-183 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain YFP-tag YFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Region 1-49 Region 1-49 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 6 unspecified role unspecified role fluorescence donor fluorescence donor CFP-tag CFP-tag cfp tag cyan fluorescent protein tag CFP cyan fluorescent protein cyan fluorescent protein CFP cfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human proximity proximity close-contact colocalization neighbourhood interaction c-apobec3a-1 4 8 unspecified role unspecified role prey prey human Homo sapiens Human 7 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association c-apobec3a-2 2 8 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 7 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association c-apobec3a-3 3 8 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept YFP-tag YFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 7 unspecified role unspecified role fluorescence donor fluorescence donor CFP-tag CFP-tag cfp tag cyan fluorescent protein tag CFP cyan fluorescent protein cyan fluorescent protein CFP cfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Region 44-149 Region 44-149 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Region 77-183 Region 77-183 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human proximity proximity close-contact colocalization neighbourhood interaction