DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure (London, England : 1993) 2014 imex curation Grande-García A., Lallous N., Díaz-Tejada C., Ramón-Maiques S. Only protein-protein interactions human Homo sapiens Human x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Grande-García A., Lallous N., Díaz-Tejada C., Ramón-Maiques S. DIP original experiment: DIP-259649X Structure (London, England : 1993) 2014 IMEx Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure (London, England : 1993) 2014 imex curation Grande-García A., Lallous N., Díaz-Tejada C., Ramón-Maiques S. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Grande-García A., Lallous N., Díaz-Tejada C., Ramón-Maiques S. DIP original experiment: DIP-259648X Structure (London, England : 1993) 2014 IMEx Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure (London, England : 1993) 2014 imex curation Grande-García A., Lallous N., Díaz-Tejada C., Ramón-Maiques S. Only protein-protein interactions human Homo sapiens Human solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Grande-García A., Lallous N., Díaz-Tejada C., Ramón-Maiques S. DIP original experiment: DIP-259647X Structure (London, England : 1993) 2014 IMEx Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. pyr1_human CAD protein CAD protein protein human Homo sapiens Human MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYGIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF DIP protein P27708 original sequence version: 163 2AB8E8413E825A8F cad-1 3 4 unspecified role unspecified role unspecified role unspecified role Region 1456-1846 Region 1456-1846 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P27708:p.Met1601Glu M1601E mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain M E This feature has been corrected as a result of our quality control procedures. The original label was 'M1601E'. Wed May 02 16:06:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'met1601glu' Tue Jun 30 18:41:27 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Met1601Glu' P27708:p.[Ala1597Thr;Ala1598Thr] A1597T/A1598T mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain A T certain certain sequence position certain certain certain sequence position certain A T This feature has been corrected as a result of our quality control procedures. The original label was 'A1597T/A1598T'. Wed May 02 14:40:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala1597thr,ala1598thr' Tue Jun 30 19:22:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala1597Thr;Ala1598Thr]' human Homo sapiens Human direct interaction direct interaction cad-2 2 4 unspecified role unspecified role unspecified role unspecified role Region 1456-1846 Region 1456-1846 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cad-3 1 4 unspecified role unspecified role unspecified role unspecified role Region 1456-1846 Region 1456-1846 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction