DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nature chemical biology 2014 imex curation Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. DIP original experiment: DIP-260167X Nature chemical biology 2014 IMEx Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nature chemical biology 2014 imex curation Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. DIP original experiment: DIP-260168X Nature chemical biology 2014 IMEx Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nature chemical biology 2014 imex curation Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. DIP original experiment: DIP-260171X Nature chemical biology 2014 IMEx Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nature chemical biology 2014 imex curation Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. DIP original experiment: DIP-260172X Nature chemical biology 2014 IMEx Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nature chemical biology 2014 imex curation Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. DIP original experiment: DIP-260170X Nature chemical biology 2014 IMEx Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nature chemical biology 2014 imex curation Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. Only protein-protein interactions in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. DIP original experiment: DIP-260169X Nature chemical biology 2014 IMEx Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nature chemical biology 2014 imex curation Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Wang WJ., Wang Y., Chen HZ., Xing YZ., Li FW., Zhang Q., Zhou B., Zhang HK., Zhang J., Bian XL., Li L., Liu Y., Zhao BX., Chen Y., Wu R., Li AZ., Yao LM., Chen P., Zhang Y., Tian XY., Beermann F., Wu M., Han J., Huang PQ., Lin T., Wu Q. DIP original experiment: DIP-260166X Nature chemical biology 2014 IMEx Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. p22736-1 Nuclear receptor subfamily 4 group A member 1 NR4A1 GFRP1 HMR NAK1 Early response protein NAK1 Nuclear hormone receptor NUR/77 Orphan nuclear receptor HMR Orphan nuclear receptor TR3 ST-59 Testicular receptor 3 protein protein human Homo sapiens Human MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF DIP protein P22736-1 original sequence version: 156 DIP protein P22736-1 original sequence version: 169 bni3l_human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like NIP3-like protein X BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A Adenovirus E1B19K-binding protein B5 BNIP3L BNIP3A BNIP3H NIX protein protein human Homo sapiens Human MSSHLVEPPPPLHNNNNNCEENEQSLPPPAGLNSSWVELPMNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQIMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLSTPSASTY DIP protein O60238 original sequence version: 126 19372E897BC63609 nr4a1_human Nuclear receptor subfamily 4 group A member 1 Orphan nuclear receptor HMR Early response protein NAK1 Orphan nuclear receptor TR3 ST-59 GFRP1 HMR NAK1 NR4A1 Nuclear hormone receptor NUR/77 Testicular receptor 3 protein protein human Homo sapiens Human MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF DIP protein P22736 original sequence version: 156 41DAAEA7C25FDA22 adt1_human ADP/ATP translocase 1 SLC25A4 ANT1 Adenine nucleotide translocator 1 ADP,ATP carrier protein 1 Solute carrier family 25 member 4 ADP,ATP carrier protein, heart/skeletal muscle isoform T1 AAC1 protein protein human Homo sapiens Human MGDHAWSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV DIP protein P12235 original sequence version: 169 59F0DFAEC4E7CFBB bnip3l-nr4a1-1 7 8 unspecified role unspecified role prey prey Region 351-598 Region 351-598 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P22736-1:p.Leu555Trp L555W mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L W This feature has been corrected as a result of our quality control procedures. The original label was 'L555W'. Wed May 02 15:10:14 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu555trp' Tue Jun 30 18:48:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu555Trp' P22736-1:p.Leu449Trp L449W mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L W This feature has been corrected as a result of our quality control procedures. The original label was 'L449W'. Wed May 02 18:18:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu449trp' Tue Jun 30 15:59:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu449Trp' P22736-1:p.Ser553Ala S553A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain S A This feature has been corrected as a result of our quality control procedures. The original label was 'S553A'. Wed May 02 16:53:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser553ala' Tue Jun 30 16:23:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser553Ala' P22736-1:p.Arg563Ala R563A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R563A'. Wed May 02 18:34:08 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg563ala' Tue Jun 30 18:56:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg563Ala' His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecolx Escherichia coli 9 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli direct interaction direct interaction slc25a4-nr4a1-1 4 11 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 8 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human physical association physical association nr4a1-bnip3l-1 5 8 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Region 351-598 Region 351-598 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 9 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association bnip3l-nr4a1-2 2 10 unspecified role unspecified role prey prey human Homo sapiens Human 9 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association bnip3l-nr4a1-3 6 8 unspecified role unspecified role prey prey His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecolx Escherichia coli 9 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli direct interaction direct interaction bnip3l-nr4a1-4 1 8 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 9 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association nr4a1-slc25a4-1 3 11 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 8 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Region 1-266 Region 1-266 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human physical association physical association