DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The architecture of Tetrahymena telomerase holoenzyme. The architecture of Tetrahymena telomerase holoenzyme. Nature 2013 imex curation Jiang J., Miracco EJ., Hong K., Eckert B., Chan H., Cash DD., Min B., Zhou ZH., Collins K., Feigon J. Only protein-protein interactions tetth Tetrahymena thermophila 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Jiang J., Miracco EJ., Hong K., Eckert B., Chan H., Cash DD., Min B., Zhou ZH., Collins K., Feigon J. DIP original experiment: DIP-252797X Nature 2013 IMEx The architecture of Tetrahymena telomerase holoenzyme. The architecture of Tetrahymena telomerase holoenzyme. The architecture of Tetrahymena telomerase holoenzyme. Nature 2013 imex curation Jiang J., Miracco EJ., Hong K., Eckert B., Chan H., Cash DD., Min B., Zhou ZH., Collins K., Feigon J. Only protein-protein interactions tetth Tetrahymena thermophila molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Jiang J., Miracco EJ., Hong K., Eckert B., Chan H., Cash DD., Min B., Zhou ZH., Collins K., Feigon J. DIP original experiment: DIP-252795X Nature 2013 IMEx The architecture of Tetrahymena telomerase holoenzyme. The architecture of Tetrahymena telomerase holoenzyme. The architecture of Tetrahymena telomerase holoenzyme. Nature 2013 imex curation Jiang J., Miracco EJ., Hong K., Eckert B., Chan H., Cash DD., Min B., Zhou ZH., Collins K., Feigon J. Only protein-protein interactions tetth Tetrahymena thermophila tem transmission electron microscopy tem predetermined predetermined participant predetermined Jiang J., Miracco EJ., Hong K., Eckert B., Chan H., Cash DD., Min B., Zhou ZH., Collins K., Feigon J. DIP original experiment: DIP-252796X Nature 2013 IMEx The architecture of Tetrahymena telomerase holoenzyme. tap45_tetts Telomerase-associated protein of 45 kDa TAP45 TTHERM_00083360 protein protein tetts Tetrahymena thermophila (strain SB210) MEDNFELVFLKELPSLPDFSKVCFTGLILSFSNFPSSEQNQQKDVPHKIAIIQDSTGEAELFLDMYKFCQEEISVFKAITGIGVLKKKNIGAGQVCKIIVERFRIIHSADEEMLQYLLIQKYKLSKTLNEQQQIKQKEQQINQQKIDKVVQDKESKEHLLWKQQQIPQIKSNQENINTLKYKELIAGELMRITHKLLIQKLQQQQPANNNKQINEMDVESNELAEKKEVIIKIQEIAKDQQLYDTLSIQYQVDQKEQYYAKIAQSLEDFVSISALKMVSYIYPNISYQVSIGFFQNILDIATKTVKDRGALGCNYKYLKDKLTKALNLQQISYPLISESYISYLVHLFQDFNIIEIENEHKFYYKQAFQYDDS DIP protein Q237B3 original sequence version: 27 larp7_tetts La-related protein 7 homolog TAP65 Telomerase-associated protein of 65 kDa TTHERM_000318539 protein protein tetts Tetrahymena thermophila (strain SB210) MDEYLENTNLEELEQECFMEDYQHEDVVEQENHQVDANDIYENQQMNDESQLNQDVKISQQKEQAVEMIEEQQQNNQDKFKQFQDCMAHITELNFKRNYQNLTEQSSSNNVVAEELDIKESLKLQMEYYFCDTNLTHDSYLRGIISKSPKNCVDIKVFLKFNKIQQILKQIQDKQIVSTYGIENQSQKKNHKNYKNQNATFSKKDLIHLIRDSLKESKILKVKMDSLKVKRRFPFNLEQALKNSKQRTLYIDFLPPKCSKQTLVSIFGNFRIININLPLQKNSQLCQGFAFIEFFSEEEANQALITKNSSIPKELILLTEKKIGQGSIRIITYKKWQEEKQSFKELSKNQNEQKNKNMNQSRKASDEFVSIDVEIKQNCLIKIINIPQGTLKAEVVLAVRHLGYEFYCDYIDENSNQINSNKISLSTQQQNTAQCSNIQIENNLIQQDQHPQLNDLLKEGQAMIRFQNSDEQRLAIQKLLNHNNNKLQIEIRGQICDVISTIPEDEEKNYWNYIKFKKNEFRKFFFMKKQQKKQNITQNYNK DIP protein W7X6T2 original sequence version: 7 tap75_tetts Telomerase-associated protein of 75 kDa TAP75 TTHERM_00059040 protein protein tetts Tetrahymena thermophila (strain SB210) MEIEEDLNLKILEDVKKLYLQSFDYIKNGISSSLPSDKKFLADDDIDLSRITFLYKFISVNPTLLLINEKTQAKRRIFQGEYLYGKKKIQFNIIAKNLEIERELIQFFKKPYQCYIMHNVQVFQMLNKNKNNNVVEFMDSEDLQSSVDCQLYYLIDESSHVLEDDSMDFISTLTRLSDSFNSNEFVFETNYSIQISQMPKPLNTTHFKLLQPKVVNSFEGVILQVQEGKNILQIEELIDQVYLNSRRDRFYILKVANGKNYMDFIEVYLVYDNEDQEAKQQLQFYLKPFQRILIFQSLKHFTKNLKLFMISFFYSSGVQPNNSNVKNFLVSHKGVEFFSRFDIQKNELLCKDLIKSYNKLPLSNISKLLEDEGVMIRSNMKFQVRVKKVKYFKIRLNCLNCKQEWTVGLKNCINCKGQQSYISYNIQVLVQDQHFLEQQAYIYLYDDLAAQFFNITESEKKELHLHLTKNETFIQLYYSFNKDYPLSIIKFKDKIFNKDITNCIVAYPFADIDNKIFNSQQQIIQDENLRIESEKFIQNFTEDNNLQESKLYYEKFKSKNKQQIFVNGTYISTNYSQGQKICLKPIPCLKVMYVFPQEDIKLSALKIIEEINQLKIQIDQLN DIP protein I7MHB0 original sequence version: 13 tap19_tetts Telomerase-associated protein of 19 kDa TAP19 TTHERM_00658760 protein protein tetts Tetrahymena thermophila (strain SB210) MQQPKRNFDLYKLITDKQIDFQVADLIQDEQSSFVSVRIYGQFKCFVPKSTIQEQLDKIKNLSSKELAKNKIFKFLSEYNKNNQKQDELSHDYYGYFKVQQHQFILNLENAQREASLAVDDFYFINGRIYKTNHDILILQAHHVYQMQKPTLQLLQAASEINQN DIP protein I7MM24 original sequence version: 7 591F49EFC6915CFA tap50_tetts Telomerase-associated protein of 50 kDa TAP50 TTHERM_01049190 protein protein tetts Tetrahymena thermophila (strain SB210) MKLLLQNQNIFQKLKNTLNGCIKKFYDTYQDLEQMQKFEMIVEDKLLFRYSCSQSEMFSAQIQAHYLEKRVLQLTDGNVKYIVNFRDKGVLDKANFFDTPNNSLVIIRQWSYEIYYTKNTFQINLVIDEMRCIDIITTIFYCKLELDFTQGIKGISKSSSFSNQIYEYSAQYYKAIQLLKKLLINDSYISELYNSTKSKQQPRLFIFQSFKPKMNLAEQNLSRQFEQCQQDDFGDGCLLQIVNYTHQSLKQIENKNNSNQIVNGQNEISKKKRVLKSNEDLYKISLQKQLKIFQEEEIELHSQSTIRNQTNQQLETFESDTSKRNSEKILHSINELNTSKQKVNQMNSSQHQIQKLENNNLNKNILNQINENDIKNELEERQQQHLTQSFNSKAQLKKIITLKKNQDILLFKPQEQEGSKKY DIP protein Q24BW8 original sequence version: 30 teb1_tetts Telomeric repeat-binding subunit 1 TEB1 TAP82 Telomerase-associated protein of 82 kDa TTHERM_00218760 protein protein tetts Tetrahymena thermophila (strain SB210) MKLTKGGSYILKKVDRKQFYQDEEIVMQIKKILGQKTTDCKQYIKCECIDGLGDEALIYFEMLANQNQHLQKNDVIMIQDYLNDKTQNDKIVVLVTRFQFCKASHVQPKTAQKESIQLLNTEKTIIQKSKITKNPAEEVLKFIEVNEKDNSSNSEDMIIEQQKQEIKNNQKEKQSINGFNLEDSYSNISDITNFGGKSNFNIGSLSDQLSKQTLLISQLQVGKNRFSFKFEGRVVYKSSTFQNQQDSKYFFITAQDANNQEINLSFWQKVDQSYQTLKVGQYYYFIGGEVKQFKNNLELKFKFGDYQIIPKETLSANYVQPLALQPSKQFGNDSIGDSDYSIHNLIEKEESIAQKGYNGQKNNKYRQNNNNSKHTLLISEVLKTSKQYLSVLAQVVDIQSSDKNIRLKICDNSCNQELKVVIFPDLCYEWRDKFSINKWYYFNEFVRQIYNDEVQLKNNIHSSIKESDDQRKVITYNQEQGVFKKSISINSNDSFEIKPKISYKNNSNQEQRIYSSIEEIIQQAQASEIGQKKEFYVYGNLVSIQMKNKLYYYRCTCQGKSVLKYHGDSFFCESCQQFINPQVHLMLRAFVQDSTGTIPVMIFDQQSSQLINQIDPSIHVQEAGQYVKNCIENGQEEIIRQLFSKLDFARFIFEIQFENKEFNNEQEIAYKVLKIEKENIKEESKYLLKKLEHLINNNQNN DIP protein I7LVX8 original sequence version: 17 tert_tetts Telomerase reverse transcriptase TERT Telomerase catalytic subunit Telomerase subunit P133 TTHERM_00112560 protein protein tetts Tetrahymena thermophila (strain SB210) MQKINNINNNKQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLTTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQIGTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKVEQNGYLQVAGVCLNQYFSVQVKQKKWYKNNFNMNGKATSNNNQNNANLSNEKKQENQYIYPEIQRSQIFYCNHMGREPGVFKSSFFNYSEIKKGFQFKVIQEKLQGRQFINSDKIKPDHPQTIIKKTLLKEYQSKNFSCQEERDLFLEFTEKIVQNFHNINFNYLLKKFCKLPENYQSLKSQVKQIVQSENKANQQSCENLFNSLYDTEISYKQITNFLRQIIQNCVPNQLLGKKNFKVFLEKLYEFVQMKRFENQKVLDYICFMDVFDVEWFVDLKNQKFTQKRKYISDKRKILGDLIVFIINKIVIPVLRYNFYITEKHKEGSQIFYYRKPIWKLVSKLTIVKLEEENLEKVEEKLIPEDSFQKYPQGKLRIIPKKGSFRPIMTFLRKDKQKNIKLNLNQILMDSQLVFRNLKDMLGQKIGYSVFDNKQISEKFAQFIEKWKNKGRPQLYYVTLDIKKCYDSIDQMKLLNFFNQSDLIQDTYFINKYLLFQRNKRPLLQIQQTNNLNSAMEIEEEKINKKPFKMDNINFPYYFNLKERQIAYSLYDDDDQILQKGFKEIQSDDRPFIVINQDKPRCITKDIIHNHLKHISQYNVISFNKVKFRQKRGIPQGLNISGVLCSFYFGKLEEEYTQFLKNAEQVNGSINLLMRLTDDYLFISDSQQNALNLIVQLQNCANNNGFMFNDQKITTNFQFPQEDYNLEHFKISVQNECQWIGKSIDMNTLEIKSIQKQTQQEINQTINVAISIKNLKSQLKNKLRSLFLNQLIDYFNPNINSFEGLCRQLYHHSKATVMKFYPFMTKLFQIDLKKSKQYSVQYGKENTNENFLKDILYYTVEDVCKILCYLQFEDEINSNIKEIFKNLYSWIMWDIIVSYLKKKKQFKGYLNKLLQKIRKSRFFYLKEGCKSLQLILSQQKYQLNKKELEAIEFIDLNNLIQDIKTLIPKISAKSNQQNTN DIP protein Q22ZB5 original sequence version: 57 tap19-tap45-1 3 7 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 4 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 8 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 5 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 6 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 9 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 10 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila physical association physical association tap19-tap45-2 2 7 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 4 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 8 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 5 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 6 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 9 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 10 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila physical association physical association tap19-tap45-3 1 9 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 10 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 7 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 4 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 8 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 5 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila 6 unspecified role unspecified role unspecified role unspecified role tetth Tetrahymena thermophila physical association physical association