DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Lin YP., Xiong X., Wharton SA., Martin SR., Coombs PJ., Vachieri SG., Christodoulou E., Walker PA., Liu J., Skehel JJ., Gamblin SJ., Hay AJ., Daniels RS., McCauley JW. Only protein-protein interactions i68a0 Influenza A virus (strain A/Aichi/2/1968 H3N2) x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Lin YP., Xiong X., Wharton SA., Martin SR., Coombs PJ., Vachieri SG., Christodoulou E., Walker PA., Liu J., Skehel JJ., Gamblin SJ., Hay AJ., Daniels RS., McCauley JW. DIP original experiment: DIP-253639X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Lin YP., Xiong X., Wharton SA., Martin SR., Coombs PJ., Vachieri SG., Christodoulou E., Walker PA., Liu J., Skehel JJ., Gamblin SJ., Hay AJ., Daniels RS., McCauley JW. Only protein-protein interactions spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Lin YP., Xiong X., Wharton SA., Martin SR., Coombs PJ., Vachieri SG., Christodoulou E., Walker PA., Liu J., Skehel JJ., Gamblin SJ., Hay AJ., Daniels RS., McCauley JW. DIP original experiment: DIP-253641X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Lin YP., Xiong X., Wharton SA., Martin SR., Coombs PJ., Vachieri SG., Christodoulou E., Walker PA., Liu J., Skehel JJ., Gamblin SJ., Hay AJ., Daniels RS., McCauley JW. Only protein-protein interactions spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Lin YP., Xiong X., Wharton SA., Martin SR., Coombs PJ., Vachieri SG., Christodoulou E., Walker PA., Liu J., Skehel JJ., Gamblin SJ., Hay AJ., Daniels RS., McCauley JW. DIP original experiment: DIP-253640X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. a0fci1_9infa Hemagglutinin HA protein protein influenza a virus (a/norway/807/2004(h3n2)) Influenza A virus (A/Norway/807/2004(H3N2)) MKTIIALSYILCLVFAQKLPGNDNSTATLCLGHHAVPNGTIVKTITNDQIEVTNATELVQSSSTGGICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWTGVTQNGTSSACKRRSNNSFFSRLNWLTHLKFKYPALNVTMPNNEKFDKLYIWGVHHPGTDNDQISLYAQASGRITVSTKRSQQTVIPNIGSRPRVRDIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCNSECITPNGSIPNDKPFQNVNRITYGACPRYVKQNTLKLATGMRNVPEKQTRGIFGAIAGFIENGWEGMVDGWYGFRHQNSEGIGQAADLKSTQAAINQINGKLNRLIGKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFERTKKQLRENAEDMGNGCFKIYHKCDNACIGSIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVALLGFIMWACQKGNIRCNICI DIP protein A0FCI1 original sequence version: 45 hema_i68a0 Hemagglutinin HA protein protein i68a0 Influenza A virus (strain A/Aichi/2/1968 H3N2) MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICI DIP protein P03437 original sequence version: 115 E395659C23CAFECA i2d7a8_9infa Hemagglutinin HA protein protein influenza a virus (a/malaysia/33386/2005(h3n2)) Influenza A virus (A/Malaysia/33386/2005(H3N2)) MKTIIALSYILCLVFAQKLPGNDNSTATLCLGHHAVPNGTIVKTITNDQIEVTNATELVQSSSTGGICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWTGVTQNGTSSACKRKSNNSFFSRLNWLTHLKFKYPALNVTMPNNEKFDKLYIWGVHHPGTDNDQIFLYAQASGRITVSTKRSQQTVIPNIGSRPRVRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCNSECITPNGSIPNDKPFQNVNRITYGACPRYVKQNTLKLATGMRNVPEKQTRGIFGAIAGFIENGWEGMVDGWYGFRHQNSEGIGQAADLKSTQAAINQINGKLNRLIGKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFERTKKQLRENAEDMGNGCFKIYHKCDNACIGSIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVALLGFIMWACQKGNIRCNICI DIP protein I2D7A8 original sequence version: 8 ha-4 1 5 unspecified role unspecified role unspecified role unspecified role Region 17-344/346-520 Region 17-344/346-520 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain i68a0 Influenza A virus (strain A/Aichi/2/1968 H3N2) direct interaction direct interaction ha-5 3 4 unspecified role unspecified role unspecified role unspecified role Region 17-519 Region 17-519 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction ha-6 2 6 unspecified role unspecified role unspecified role unspecified role Region 17-519 Region 17-519 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction