DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251017X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251014X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251023X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251018X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251019X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro ion exchange chrom ion exchange chromatography IEC IEC ion exchange chrom predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251024X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro phosphatase assay phosphatase assay predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251020X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro phosphatase assay phosphatase assay predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251021X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251015X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251016X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (London, England : 1993) 2012 imex curation O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. Only protein-protein interactions in vitro In vitro phosphatase assay phosphatase assay predetermined predetermined participant predetermined O'Connell N., Nichols SR., Heroes E., Beullens M., Bollen M., Peti W., Page R. DIP original experiment: DIP-251022X Structure (London, England : 1993) 2012 IMEx The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. pygm_rabit Glycogen phosphorylase, muscle form Myophosphorylase PYGM protein protein rabit Oryctolagus cuniculus (Rabbit) Rabbit MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKIP DIP protein P00489 original sequence version: 110 DIP protein P00489 original sequence version: 133 9884F06FDD3AE9D3 cdk2_human Cyclin-dependent kinase 2 CDK2 p33 protein kinase Cell division protein kinase 2 CDKN2 protein protein human Homo sapiens Human MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL DIP protein P24941 original sequence version: 142 DIP protein P24941 original sequence version: 118 DIP protein P24941 original sequence version: 143 DIP protein P24941 original sequence version: 144 DIP protein P24941 original sequence version: 152 DIP protein P24941 original sequence version: 182 DIP protein P24941-1 original sequence version: 204 DIP protein P24941 original sequence version: 90 DIP protein P24941 original sequence version: 190 DIP protein P24941 original sequence version: 168 F90A0F4E70910B51 cdc5l_human Cell division cycle 5-like protein CDC5L Pombe cdc5-related protein KIAA0432 PCDC5RP protein protein human Homo sapiens Human MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEKETLKSKF DIP protein Q99459 original sequence version: 121 3390F91EE7E79DA6 pp1a_human Serine/threonine-protein phosphatase PP1-alpha catalytic subunit PPP1CA PPP1A protein protein human Homo sapiens Human MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK DIP protein P62136 original sequence version: 72 DIP protein P62136 original sequence version: 76 DIP protein P62136 original sequence version: 123 DIP protein P62136 original sequence version: 126 DIP protein P62136-1 original sequence version: 98 60C37E1AD9831DAC q12972-1 Nuclear inhibitor of protein phosphatase 1 NIPP1 Protein phosphatase 1 regulatory inhibitor subunit 8 PPP1R8 ARD1 protein protein human Homo sapiens Human MAAAANSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEGPGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIHGTALIGGLPMPYPNLAPDVDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLLI DIP protein Q12972-1 original sequence version: 121 ccna2_bovin Cyclin-A2 CCNA2 protein protein bovin Bos taurus (Bovine) Bovine MLGSSAHGPAAREAGSAVTLQQTAFQEDQENVNPEKAAPAQQPRTRAGLAVLRAGNSRGPAPQRPKTRRVAPLKDLPINDEYVPVPPWKANNKQPAFTIHVDEAEEEIQKRPTESKKSESEDVLAFNSAVTLPGPRKPLAPLDYPMDGSFESPHTMEMSVVLEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIREKYKNSKYHGVSLLNPPETLNV DIP protein P30274 original sequence version: 127 DIP protein P30274 original sequence version: 107 o75533-1 Splicing factor 3B subunit 1 SF3B1 SAP155 Pre-mRNA-splicing factor SF3b 155 kDa subunit Spliceosome-associated protein 155 protein protein human Homo sapiens Human MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKGSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL DIP protein O75533-1 original sequence version: 141 DIP protein O75533 original sequence version: 65 DIP protein O75533 original sequence version: 145 DIP protein O75533 original sequence version: 120 ppp1ca-ppp1r8-5 10 16 unspecified role unspecified role unspecified role unspecified role Region 144-225 Region 144-225 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 7-330 Region 7-330 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ppp1ca-ppp1r8-6 2 16 unspecified role unspecified role unspecified role unspecified role Region 158-216 Region 158-216 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 7-330 Region 7-330 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ppp1ca-ppp1r8-7 3 16 unspecified role unspecified role prey prey Region 158-216 Region 158-216 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role bait bait Region 7-307 Region 7-307 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli physical association physical association ccna2-cdk2-15 4 13 unspecified role unspecified role prey prey ecolx Escherichia coli 17 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli physical association physical association ppp1ca-sf3b1-1 8 18 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 1-491 Region 1-491 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 enzyme enzyme unspecified role unspecified role Region 7-330 Region 7-330 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli dephosphorylation dephosphorylation reaction dephosphorylation ppp1ca-ppp1r8-8 1 16 unspecified role unspecified role unspecified role unspecified role Region 158-216 Region 158-216 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 7-307 Region 7-307 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ppp1ca-ppp1r8-9 9 16 unspecified role unspecified role unspecified role unspecified role Region 158-216 Region 158-216 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 7-307 Region 7-307 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ccna2-cdk2-16 5 13 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction ppp1ca-ppp1r8-10 6 16 unspecified role unspecified role unspecified role unspecified role Region 158-216 Region 158-216 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 7-307 Region 7-307 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cdc5l-ppp1ca-1 7 14 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 260-606 Region 260-606 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 enzyme enzyme unspecified role unspecified role Region 7-330 Region 7-330 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli dephosphorylation dephosphorylation reaction dephosphorylation ppp1ca-pygm-1 11 12 enzyme target enzyme target substrate substrate unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit 15 enzyme enzyme unspecified role unspecified role Region 7-330 Region 7-330 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli dephosphorylation dephosphorylation reaction dephosphorylation