<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="22323590" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.1115634109" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15967853" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-20637" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2012</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Fu M.,  Zhang W.,  Wu L.,  Yang G.,  Li H.,  Wang R.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-20637" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-251525X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="22323590" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.1115634109" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="10090">
            <names>
              <shortLabel>mouse</shortLabel>
              <fullName>Mus musculus</fullName>
              <alias type="synonym" typeAc="MI:1041">Mouse</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Fu M., Zhang W., Wu L., Yang G., Li H., Wang R.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-251525X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2012</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>tom20_mouse</shortLabel>
          <fullName>Mitochondrial import receptor subunit TOM20 homolog</fullName>
          <alias type="gene name" typeAc="MI:0301">Tomm20</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Mitochondrial 20 kDa outer membrane protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Outer mitochondrial membrane receptor Tom20</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9DCC8" version="SP_56" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="MINT-4616302" refType="intact-secondary"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000136493" version="SP_165" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8071628" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_077176.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-60017N"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000093904" version="SP_165" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000179857" version="SP_165" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005740" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005741" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005742" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006626" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0014850" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015450" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016031" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030150" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030943" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031307" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044233" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051082" version="SP_165"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905242" version="SP_165"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002056" version="SP_165"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR022422" version="SP_165"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023392" version="SP_165"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5205685" version="SP_165"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5689880" version="SP_165"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGDYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q9DCC8 original sequence version: 100</attribute>
          <attribute name="function" nameAc="MI:0613">Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
          <attribute name="crc64">50E3BD25AD5C9B3B</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>cgl_mouse</shortLabel>
          <fullName>Cystathionine gamma-lyase</fullName>
          <alias type="gene name" typeAc="MI:0301">Cth</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cysteine-protein sulfhydrase</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Gamma-cystathionase</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q8VCN5" version="SP_41" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="MINT-1855831" refType="intact-secondary"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6H324" version="SP_60" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000113672" version="SP_144" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8363035" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_666065.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-60018N"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000028179" version="SP_144" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000118539" version="SP_144" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004121" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004123" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006749" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016846" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0018272" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019343" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019344" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019346" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030170" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030308" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043123" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044524" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044540" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050667" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051289" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070814" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0080146" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904831" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990830" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001234" version="SP_144"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000277" version="SP_144"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015421" version="SP_144"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015422" version="SP_144"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015424" version="SP_144"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q8VCN5" version="SP_144"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1614558" version="SP_144"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1614603" version="SP_144"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005516" version="SP_144"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MQKDASLSGFLPSFQHFATQAIHVGQEPEQWNSRAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAAHP</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q8VCN5 original sequence version: 81</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
          <attribute name="crc64">B2F89625B9978599</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-20637-1">
        <names>
          <shortLabel>cth-tomm20-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-190234E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15967872" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-20637-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10090">
                <names>
                  <shortLabel>mouse</shortLabel>
                  <fullName>Mus musculus</fullName>
                  <alias type="synonym" typeAc="MI:1041">Mouse</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10090">
                <names>
                  <shortLabel>mouse</shortLabel>
                  <fullName>Mus musculus</fullName>
                  <alias type="synonym" typeAc="MI:1041">Mouse</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>