DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS biology 2012 imex curation Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. DIP original experiment: DIP-249343X PLoS biology 2012 IMEx Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS biology 2012 imex curation Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. DIP original experiment: DIP-249342X PLoS biology 2012 IMEx Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS biology 2012 imex curation Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. DIP original experiment: DIP-249340X PLoS biology 2012 IMEx Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS biology 2012 imex curation Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. DIP original experiment: DIP-249339X PLoS biology 2012 IMEx Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS biology 2012 imex curation Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Li S., Chen Y., Shi Q., Yue T., Wang B., Jiang J. DIP original experiment: DIP-249341X PLoS biology 2012 IMEx Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. ubiq_drome Ubiquitin RpL40 CG2960 RpS27A UBI-F80 Ubi-f CG5271 Ubi-p63E Ubi-m CG11624 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG C42A35397FFD9B52 friz2_drome Frizzled-2 CG9739 fz2 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MRHNRLKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVASTSHHHLHHHVLKQPAASHV DIP protein Q9VVX3 original sequence version: 132 DIP protein Q9VVX3 original sequence version: 122 DIP protein Q9VVX3 original sequence version: 106 6C510F13CBAFB096 smo_drome Protein smoothened smo CG11561 dSMO SMOH Smooth protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MQYLNFPRMPNIMMFLEVAILCLWVVADASASSAKFGSTTPASAQQSDVELEPINGTLNYRLYAKKGRDDKPWFDGLDSRHIQCVRRARCYPTSNATNTCFGSKLPYELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRCNETLFPTKCTNGARGMKFNGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSITLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLDSEISVSVRHVSVESRRNSVDSQVSVKIAEMKTKVASRSRGKHGGSSSNRRTQRRRDYIAAATGKSSRRRESSTSVESQVIALKKTTYPNASHKVGVFAHHSSKKQHNYTSSMKRRTANAGLDPSILNEFLQKNGDFIFPFLQNQDMSSSSEEDNSRASQKIQDLNVVVKQQEISEDDHDGIKIEELPNSKQVALENFLKNIKKSNESNSNRHSRNSARSQSKKSQKRHLKNPAADLDFRKDCVKYRSNDSLSCSSEELDVALDVGSLLNSSFSGISMGKPHSRNSKTSCDVGIQANPFELVPSYGEDELQQAMRLLNAASRQRTEAANEDFGGTELQGLLGHSHRHQREPTFMSESDKLKMLLLPSK DIP protein P91682 original sequence version: 121 DIP protein P91682 original sequence version: 141 DIP protein P91682 original sequence version: 105 7797FC71A539A87A q9v393_drome krz CG1487 0952 14 Dmel\CG1487 Krz Kurz l(3)S095214 Dmel_CG1487 beta-arr2 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MNGGGGGSGGANVSNGSSTNVTAAGSTGGGSAGDETGGDASSRRQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAFRYGREDLDVLGLTFRKDLYLAHEQIYPPMQLDRPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVSLQPAPGDVGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFMMKPNKIHLEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEIESEDGCQVAPGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMVHYKVKVKLLISSPLLNGDLVAELPFTLMHPKPEEEEHPLLGERSPRASLAGGGLPLVSMSDGETESATGGQDVPTTTNLIQLDDDEAQDDDIIFEDFARLRLKGAETEA DIP protein Q9V393 original sequence version: 89 FEF954324007C26A q9vdd8_drome Ubiquitin carboxyl-terminal hydrolase Usp8 Ubpy Ubpy-RA CT18196 Dmel\CG5798 Q9VDD8 UBPY USP8 UbpY dUBPY ubpy usp8 Dmel_CG5798 CG5798 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MAKLKKLHMSSNLDDLEKMSIIPDLRSKGMKILLNTARKLYMTAEEYRLDGDEELAYITYMKYFNMLTAIHKKSDYPSHKTTVRQMLGDTESNRRIMDTLEEIINSLRHRYAQQHQAPEPIAPDLVSNGRAGVDSPITQPTQYARLGLITCQDLYRRMQEKSVLVMDCRPSADYEASHLTYYCAFNVPEELITPGMSAGRLQARLSSSAKASWASRSVKDSVVLMDWNTKDAQPATNTAISTLLDILKNWDPDVTYRAPIQIVEGGYEYFIMMYPTHCTNPSVQAPQQNNNDIETIDDIEYPSIHDITMKEDISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKMWKRQAAEGDGLNATEDQELHFRILQLESKAQDYIVENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKIRERQRLDEQHELERQERERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFYTWLPPMQVPL DIP protein Q9VDD8 original sequence version: 77 C513902A42432416 smo-ub-1 4 6 unspecified role unspecified role prey prey drome Drosophila melanogaster (Fruit fly) Fruit fly 8 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P91682:p.[Ser667Asp;Ser670Asp;Ser673Asp;Ser687Asp;Ser690Asp;Ser693Asp;Ser740Asp;Ser743Asp;Ser746Asp] S667D/S670D/S673D/S687D/S690D/S693D/S740D/S743D/S746D mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D This feature has been corrected as a result of our quality control procedures. The original label was 'S667D/S670D/S673D/S687D/S690D/S693D/S740D/S743D/S746D'. Wed May 02 16:23:51 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser667asp,ser670asp,ser673asp,ser687asp,ser690asp,ser693asp,ser740asp,ser743asp,ser746asp' Tue Jun 30 18:42:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser667Asp;Ser670Asp;Ser673Asp;Ser687Asp;Ser690Asp;Ser693Asp;Ser740Asp;Ser743Asp;Ser746Asp]' P91682:p.[Lys665Arg;Lys695Arg;Lys700Arg;Lys702Arg;Lys710Arg;Lys733Arg;Lys752Arg;Lys753Arg;Lys762Arg;Lys772Arg;Lys773Arg;Lys782Arg;Lys801Arg] K665R/K695R/K700R/K702R/K710R/K733R/K752R/K753R/K762R/K772R/K773R/K782R/K801R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K665R/K695R/K700R/K702R/K710R/K733R/K752R/K753R/K762R/K772R/K773R/K782R/K801R'. Wed May 02 18:30:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys665arg,lys695arg,lys700arg,lys702arg,lys710arg,lys733arg,lys752arg,lys753arg,lys762arg,lys772arg,lys773arg,lys782arg,lys801arg' Tue Jun 30 17:58:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys665Arg;Lys695Arg;Lys700Arg;Lys702Arg;Lys710Arg;Lys733Arg;Lys752Arg;Lys753Arg;Lys762Arg;Lys772Arg;Lys773Arg;Lys782Arg;Lys801Arg]' P91682:p.[Lys665Arg;Lys695Arg;Lys700Arg;Lys702Arg;Lys710Arg;Lys733Arg] K665R/K695R/K700R/K702R/K710R/K733R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K665R/K695R/K700R/K702R/K710R/K733R'. Wed May 02 19:55:22 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys665arg,lys695arg,lys700arg,lys702arg,lys710arg,lys733arg' Tue Jun 30 17:17:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys665Arg;Lys695Arg;Lys700Arg;Lys702Arg;Lys710Arg;Lys733Arg]' P91682:p.[Lys752_Lys753delinsArgArg;Lys762Arg;Lys772_Lys773delinsArgArg;Lys782Arg;Lys801Arg] K752R/K753R/K762R/K772R/K773R/K782R/K801R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain KK RR certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain KK RR Wed May 02 16:53:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys_lys752-753arg_arg,lys762arg,lys_lys772-773arg_arg,lys782arg,lys801arg' Tue Jun 30 17:38:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys752_Lys753delinsArgArg;Lys762Arg;Lys772_Lys773delinsArgArg;Lys782Arg;Lys801Arg]' drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association Deletion of region 661-818 decreased the interaction rate/strength. smo-krz-1 2 9 unspecified role unspecified role prey prey YFP-tag YFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range drome Drosophila melanogaster (Fruit fly) Fruit fly 8 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range C-terminal domain Region 556-1036 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain P91682:p.[Ser667Asp;Ser670Asp;Ser673Asp;Ser687Asp;Ser690Asp;Ser693Asp;Ser740Asp;Ser743Asp;Ser746Asp] S667D/S670D/S673D/S687D/S690D/S693D/S740D/S743D/S746D mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D This feature has been corrected as a result of our quality control procedures. The original label was 'S667D/S670D/S673D/S687D/S690D/S693D/S740D/S743D/S746D'. Wed May 02 14:54:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser667asp,ser670asp,ser673asp,ser687asp,ser690asp,ser693asp,ser740asp,ser743asp,ser746asp' Tue Jun 30 16:46:20 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser667Asp;Ser670Asp;Ser673Asp;Ser687Asp;Ser690Asp;Ser693Asp;Ser740Asp;Ser743Asp;Ser746Asp]' drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association smo-usp8-4 5 10 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly 8 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range C-terminal domain Region 556-1036 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association fz2-ub-1 1 7 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly 6 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association smo-ub-2 3 6 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal drome Drosophila melanogaster (Fruit fly) Fruit fly 8 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P91682:p.[Lys665Arg;Lys695Arg;Lys700Arg;Lys702Arg;Lys710Arg;Lys733Arg;Lys752Arg;Lys753Arg;Lys762Arg;Lys772Arg;Lys773Arg;Lys782Arg;Lys801Arg] K665R/K695R/K700R/K702R/K710R/K733R/K752R/K753R/K762R/K772R/K773R/K782R/K801R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K665R/K695R/K700R/K702R/K710R/K733R/K752R/K753R/K762R/K772R/K773R/K782R/K801R'. Wed May 02 15:58:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys665arg,lys695arg,lys700arg,lys702arg,lys710arg,lys733arg,lys752arg,lys753arg,lys762arg,lys772arg,lys773arg,lys782arg,lys801arg' Tue Jun 30 18:49:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys665Arg;Lys695Arg;Lys700Arg;Lys702Arg;Lys710Arg;Lys733Arg;Lys752Arg;Lys753Arg;Lys762Arg;Lys772Arg;Lys773Arg;Lys782Arg;Lys801Arg]' P91682:p.[Lys752_Lys753delinsArgArg;Lys762Arg;Lys772_Lys773delinsArgArg;Lys782Arg;Lys801Arg] K752R/K753R/K762R/K772R/K773R/K782R/K801R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain KK RR certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain KK RR Wed May 02 16:27:34 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys_lys752-753arg_arg,lys762arg,lys_lys772-773arg_arg,lys782arg,lys801arg' Tue Jun 30 17:28:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys752_Lys753delinsArgArg;Lys762Arg;Lys772_Lys773delinsArgArg;Lys782Arg;Lys801Arg]' P91682:p.[Lys665Arg;Lys695Arg;Lys700Arg;Lys702Arg;Lys710Arg;Lys733Arg] K665R/K695R/K700R/K702R/K710R/K733R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K665R/K695R/K700R/K702R/K710R/K733R'. Wed May 02 18:02:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys665arg,lys695arg,lys700arg,lys702arg,lys710arg,lys733arg' Tue Jun 30 19:30:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys665Arg;Lys695Arg;Lys700Arg;Lys702Arg;Lys710Arg;Lys733Arg]' drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association