<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>HPIDb</shortLabel>
        <fullName>Host Pathogen Interaction database</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1335" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6598961" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.agbase.msstate.edu/hpi/main.html</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17b.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="21947777" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-14001247" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-25965" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17b.</attribute>
            <attribute name="journal" nameAc="MI:0885">Infection and immunity</attribute>
            <attribute name="publication year" nameAc="MI:0886">2011</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Shames SR., Croxen MA., Deng W., Finlay BB.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">bfinlay@interchange.ubc.ca</attribute>
            <attribute name="author-announcement">8-Jun-2017: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="21947777" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-25965" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-293t</shortLabel>
              <fullName>Homo sapiens 293 cells transformed with SV40 large T antigen</fullName>
            </names>
            <cellType>
              <names>
                <shortLabel>293t</shortLabel>
                <fullName>293 cells expressing SV40 large T antigen.</fullName>
              </names>
              <xref>
                <primaryRef db="cabri" dbAc="MI:0246" id="ICLC HTL04001" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="IA:0074" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="cabri" dbAc="MI:0246" id="ACC 635" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="mint" dbAc="MI:0471" id="MINT-1891516" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-308000" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="3031469" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
              <attributeList>
                <attribute name="comment" nameAc="MI:0612">The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB.</attribute>
              </attributeList>
            </cellType>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti tag coip</shortLabel>
            <fullName>anti tag coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti tag coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0007" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-90" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>anti tag western</shortLabel>
            <fullName>anti tag western blot</fullName>
            <alias type="synonym" typeAc="MI:1041">anti tag western</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0705" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-967832" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Shames SR., Croxen MA., Deng W., Finlay BB.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">bfinlay@interchange.ubc.ca</attribute>
          <attribute name="accepted">Accepted 2017-APR-10 AT 14:29 BST AT 14:29 BST by MGT</attribute>
          <attribute name="journal" nameAc="MI:0885">Infection and immunity</attribute>
          <attribute name="publication year" nameAc="MI:0886">2011</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>ti17b_human</shortLabel>
          <fullName>Mitochondrial import inner membrane translocase subunit Tim17-B</fullName>
          <alias type="gene name" typeAc="MI:0301">TIMM17B</alias>
          <alias type="gene name synonym" typeAc="MI:0302">TIM17B</alias>
          <alias type="orf name" typeAc="MI:0306">JM3</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="O60830" version="SP_73" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UJV0" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K2E2" version="SP_75" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="J3KPV3" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000365766" version="SP_170" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2372529" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001161419.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_005825.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000126768" version="SP_170" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000376582" version="SP_170" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005743" version="SP_170"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005744" version="SP_170"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006626" version="SP_170"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008320" version="SP_170"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030150" version="SP_170"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031305" version="SP_170"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005678" version="SP_170"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1268020" version="SP_170"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGIRHRLRGSANAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSGPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFRNAPPFLEDPSQLPPKDGTPAPGYPSYQQYH</sequence>
        <attributeList>
          <attribute name="crc64">5DF3926F815E835A</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>q7db68_eco57</shortLabel>
          <alias type="orf name" typeAc="MI:0306">ECs_4571</alias>
          <alias type="orf name" typeAc="MI:0306">E5F08_27455</alias>
          <alias type="gene name" typeAc="MI:0301">espZ</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q7DB68" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblbacteria" id="BAB37994" version="TrEMBL_101" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblbacteria" id="QCH80437" version="TrEMBL_101" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A0A6M0JMB5" version="TrEMBL_97" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q7A9P1" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A0A0H3JLG1" version="TrEMBL_81" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-14029721" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblbacteria" id="QCH80437" version="TrEMBL_101" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="TrEMBL_101"/>
          <secondaryRef db="ensemblbacteria" id="BAB37994" version="TrEMBL_101" refType="transcript"/>
          <secondaryRef db="ensemblbacteria" id="CAM50_0000360" version="TrEMBL_101" refType="gene"/>
          <secondaryRef db="ensemblbacteria" id="ECs_4571" version="TrEMBL_101" refType="gene"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_312598.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="WP_000386949.1"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009275"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="83334">
          <names>
            <shortLabel>eco57</shortLabel>
            <fullName>Escherichia coli O157:H7</fullName>
          </names>
        </organism>
        <sequence>MEAANLSPSGAVMPLATSLSGNNSVDEKTGVIKPENGTNRTVRVIAGLALTTTALAALGTGIAAACSETSSTEYLALGITSGVLGTLTAVGGALAMKYA</sequence>
        <attributeList>
          <attribute name="crc64">7CDD4A41B0E0E7E0</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-25965-1">
        <names>
          <shortLabel>espz-tim17b-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-14022352" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-25965-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="6">
                <names>
                  <shortLabel>flag tag</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-14022355" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>flag tag</shortLabel>
                    <fullName>flag tag</fullName>
                    <alias type="go synonym" typeAc="MI:0303">FLAG-tagged</alias>
                    <alias type="go synonym" typeAc="MI:0303">FLAG</alias>
                    <alias type="go synonym" typeAc="MI:0303">DYKDDDDKV epitope tag</alias>
                    <alias type="synonym" typeAc="MI:1041">DYKDDDDKV epitope tag</alias>
                    <alias type="synonym" typeAc="MI:1041">FLAG</alias>
                    <alias type="synonym" typeAc="MI:1041">FLAG-tagged</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0518" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456503" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>c-term range</shortLabel>
                        <fullName>C-terminal range</fullName>
                        <alias type="synonym" typeAc="MI:1041">c-term range</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1039" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929799" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <endStatus>
                      <names>
                        <shortLabel>c-term range</shortLabel>
                        <fullName>C-terminal range</fullName>
                        <alias type="synonym" typeAc="MI:1041">c-term range</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1039" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929799" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
          </participant>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="8">
                <names>
                  <shortLabel>c terminal</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-14022369" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>gfp tag</shortLabel>
                    <fullName>green fluorescent protein tag</fullName>
                    <alias type="go synonym" typeAc="MI:0303">GFP</alias>
                    <alias type="go synonym" typeAc="MI:0303">green fluorescent protein</alias>
                    <alias type="synonym" typeAc="MI:1041">GFP</alias>
                    <alias type="synonym" typeAc="MI:1041">green fluorescent protein</alias>
                    <alias type="synonym" typeAc="MI:1041">gfp tag</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0367" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608965" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="7491768" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>c-term range</shortLabel>
                        <fullName>C-terminal range</fullName>
                        <alias type="synonym" typeAc="MI:1041">c-term range</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1039" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929799" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <endStatus>
                      <names>
                        <shortLabel>c-term range</shortLabel>
                        <fullName>C-terminal range</fullName>
                        <alias type="synonym" typeAc="MI:1041">c-term range</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1039" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929799" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">3</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>