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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
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      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.</fullName>
        </names>
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          <xref>
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            <attribute name="publication title" nameAc="MI:1091">Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2011</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Egawa T.,  Littman DR.</attribute>
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        <hostOrganismList>
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            <names>
              <shortLabel>mouse</shortLabel>
              <fullName>Mus musculus</fullName>
              <alias type="synonym" typeAc="MI:1041">Mouse</alias>
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          <names>
            <shortLabel>anti bait coip</shortLabel>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
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          <xref>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Egawa T., Littman DR.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-249693X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2011</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.</attribute>
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      </experimentDescription>
      <experimentDescription id="2">
        <names>
          <fullName>Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.</fullName>
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          <attributeList>
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            <attribute name="publication year" nameAc="MI:0886">2011</attribute>
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              <shortLabel>mouse</shortLabel>
              <fullName>Mus musculus</fullName>
              <alias type="synonym" typeAc="MI:1041">Mouse</alias>
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        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
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        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
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          <xref>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Egawa T., Littman DR.</attribute>
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          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2011</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="3">
        <names>
          <shortLabel>runx1_mouse</shortLabel>
          <fullName>Runt-related transcription factor 1</fullName>
          <alias type="gene name" typeAc="MI:0301">Runx1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Aml1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cbfa2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Pebp2ab</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Acute myeloid leukemia 1 protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Core-binding factor subunit alpha-2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Oncogene AML-1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Polyomavirus enhancer-binding protein 2 alpha B subunit</alias>
          <alias type="gene name synonym" typeAc="MI:0302">SL3-3 enhancer factor 1 alpha B subunit</alias>
          <alias type="gene name synonym" typeAc="MI:0302">SL3/AKV core-binding factor alpha B subunit</alias>
        </names>
        <xref>
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          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8877330"/>
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          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-9018519"/>
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        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDGGPALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQYLGSITSSSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDPRQFPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSASRYHTYLPPPYPGSSQAQAGPFQTGSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDVVETEGSHSNSPTNMPPARLEEAVWRPY</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q03347 original sequence version: 136</attribute>
          <attribute name="remark-internal">DIP protein Q03347 original sequence version: 128</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>q9jiz5_mouse</shortLabel>
          <alias type="gene name" typeAc="MI:0301">Tfap4</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Ap4</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Tcfap4</alias>
        </names>
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          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000005862" version="TrEMBL_166" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000005718" version="TrEMBL_166" refType="gene"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000981" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001228" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006978" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010629" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0017053" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042826" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043392" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043565" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043922" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043923" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044772" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045736" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045892" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0065003" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070888" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071549" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1901990" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990837" version="TrEMBL_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001269" version="TrEMBL_166"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011598" version="TrEMBL_166"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036638" version="TrEMBL_166"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_112459.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-59708N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MEYFMVPTQKVPSLQHFRKTEKEVIGGLCSLANIPLTPETQRDQERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDLRREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQHLRTQLLPPPAPTHHPTVIVPAPAPPSSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQDKQELEEEQRRAVIVKSVRSCPDAHTSDTASDSEASDSDAMDQSREEPLGDGELP</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q9JIZ5 original sequence version: 110</attribute>
          <attribute name="remark-internal">DIP protein Q9JIZ5 original sequence version: 90</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5" imexId="IM-17750-1">
        <names>
          <shortLabel>runx1-tfap4-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-189160E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15941635" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-17750-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10090">
                <names>
                  <shortLabel>mouse</shortLabel>
                  <fullName>Mus musculus</fullName>
                  <alias type="synonym" typeAc="MI:1041">Mouse</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="7">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10090">
                <names>
                  <shortLabel>mouse</shortLabel>
                  <fullName>Mus musculus</fullName>
                  <alias type="synonym" typeAc="MI:1041">Mouse</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
      <interaction id="8" imexId="IM-17750-2">
        <names>
          <shortLabel>tfap4-runx1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-189160E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15941652" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-17750-2" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>2</experimentRef>
        </experimentList>
        <participantList>
          <participant id="9">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10090">
                <names>
                  <shortLabel>mouse</shortLabel>
                  <fullName>Mus musculus</fullName>
                  <alias type="synonym" typeAc="MI:1041">Mouse</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="10">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10090">
                <names>
                  <shortLabel>mouse</shortLabel>
                  <fullName>Mus musculus</fullName>
                  <alias type="synonym" typeAc="MI:1041">Mouse</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>