DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253857X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253863X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253864X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253858X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253861X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253860X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253856X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253859X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253862X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253865X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253855X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. bag1_rat BAG family molecular chaperone regulator 1 Bag1 Bcl-2-associated athanogene 1 protein protein rat Rattus norvegicus (Rat) Rat MADRGGARRPRGDQEPLGPRLRAPRSARETRQSESRAERGLPPSQRSSVRSAASGHDRSTRGAASGACKPRVKKKVRPRSSQSEKVAHSKELTRSKKLTRSKKVTGTQEATQVEEVTTIEEATQTEEITVAEEVTQTENMAQTEEMVQTEEMEPPTLSVVVTHSNERYDLLVTPQQGNSEPIVQDLAQLVEEATGVPLPFQKLIFKGKSLKEMETPLSALGMQNGCRVMLIGEKSNPEEEAELKKLKDLEVSVEKTANHLEELNKELSDIQQGFLAKELQAEALCRLDRKIKATIEQFMKILEEIDTMVLPENFKDSRLKRKNLVKKVQVFLAECDTVEQYICQETERLQSTNLALPE DIP protein B0K019 original sequence version: 37 esr1_rat Estrogen receptor Esr1 Esr Estr Nr3a1 Estradiol receptor ER-alpha Nuclear receptor subfamily 3 group A member 1 protein protein rat Rattus norvegicus (Rat) Rat MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAYEFNAAAAAAAAGASAPVYGQSSITYGPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPPHVSPFLHPHGHQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSSEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGTSGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKINDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI DIP protein P06211 original sequence version: 143 mint Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues C9C7D8CACE0F57D8 esr2_rat Estrogen receptor beta Esr2 Erbeta Nr3a2 Nuclear receptor subfamily 3 group A member 2 protein protein rat Rattus norvegicus (Rat) Rat MEIKNSPSSLSSPASYNCSQSILPLEHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPGSTSNLDGGPVRLSTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVHCLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ DIP protein Q62986 original sequence version: 125 ubiq_rat Ubiquitin Rps27a Uba80 Ubcep1 Uba52 Ubcep2 Ubb protein protein rat Rattus norvegicus (Rat) Rat MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair mint C42A35397FFD9B52 f10a1_rat Hsc70-interacting protein Protein ST13 homolog Protein FAM10A1 St13 Fam10a1 Hip protein protein rat Rattus norvegicus (Rat) Rat MDPRKVSELRAFVKMCRQDPSVLHTEEMRFLREWVESMGGKVPPATHKAKSEENTKEEKRDKTTEDNIKTEEPSSEESDLEIDNEGVIEADTDAPQEMGDENAEITEAMMDEANEKKGAAIDALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAARDLALACKLDYDEDASAMLREVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHEKAQREEEARRQSGSQFGSFPGGFPGGMPGNFPGGMPGMGGAMPGMAGMPGLNEILSDPEVLAAMQDPEVMVAFQDVAQNPSNMSKYQNNPKVMNLISKLSAKFGGHS DIP protein P50503 original sequence version: 92 DIP protein P50503 original sequence version: 97 1AEBFC0526AE5CE1 nedd8_rat NEDD8 Nedd8 Neddylin Ubiquitin-like protein NEDD8 protein protein rat Rattus norvegicus (Rat) Rat MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLGQ DIP protein Q71UE8 original sequence version: 66 esr1-st13-1 9 13 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 16 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat physical association physical association esr1-ub-3 11 15 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 13 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat physical association physical association ub-esr1-1 4 15 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 13 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat physical association physical association st13-bag1-2 6 13 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 12 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 16 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat association association esr1-nedd8-1 10 13 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 17 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat physical association physical association esr2-ub-1 3 15 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 14 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat physical association physical association ub-esr1-2 7 15 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 13 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat physical association physical association esr1-bag1-1 8 13 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 12 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 16 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat association association esr2-st13-1 2 15 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 14 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 16 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat association association esr1-bag1-2 5 15 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 13 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 12 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 16 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat association association esr1-ub-4 1 15 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 13 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat physical association physical association