DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH. How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Eckenroth BE., Steere AN., Chasteen ND., Everse SJ., Mason AB. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Eckenroth BE., Steere AN., Chasteen ND., Everse SJ., Mason AB. DIP original experiment: DIP-249649X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH. How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH. How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH. Proceedings of the National Academy of Sciences of the United States of America 2011 imex curation Eckenroth BE., Steere AN., Chasteen ND., Everse SJ., Mason AB. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Eckenroth BE., Steere AN., Chasteen ND., Everse SJ., Mason AB. DIP original experiment: DIP-249650X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH. trfe_human Serotransferrin Siderophilin Beta-1 metal-binding globulin TF PRO1400 protein protein human Homo sapiens Human MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP DIP protein P02787 original sequence version: 123 DIP protein P02787 original sequence version: 144 DIP protein P02787 original sequence version: 156 DIP protein P02787 original sequence version: 165 DIP protein P02787 original sequence version: 161 DIP protein P02787 original sequence version: 170 9A73B90D8C5671E9 tfr1_human Transferrin receptor protein 1 TFRC T9 p90 protein protein human Homo sapiens Human MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF DIP protein P02786 original sequence version: 191 DIP protein P02786 original sequence version: 117 DIP protein P02786 original sequence version: 139 DIP protein P02786 original sequence version: 146 DIP protein P02786 original sequence version: 137 DIP protein P02786 original sequence version: 150 DIP protein P02786 original sequence version: 160 DIP protein P02786 original sequence version: 190 C886F14000D90154 tf-tfrc-5 1 3 unspecified role unspecified role unspecified role unspecified role Region 20-698 Region 20-698 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P02787:p.[Asn432Asp;Tyr445Phe;Tyr536Phe;Asn630Asp] Y426F/Y517F/N413D/N611D mutation mutation certain certain sequence position certain certain certain sequence position certain N D certain certain sequence position certain certain certain sequence position certain Y F certain certain sequence position certain certain certain sequence position certain Y F certain certain sequence position certain certain certain sequence position certain N D Wed May 02 16:47:43 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn432asp,tyr445phe,tyr536phe,asn630asp' Tue Jun 30 18:28:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Asn432Asp;Tyr445Phe;Tyr536Phe;Asn630Asp]' hamsters Cricetinae 4 unspecified role unspecified role unspecified role unspecified role Region 121-760 Region 121-760 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain hamsters Cricetinae direct interaction direct interaction tf-tfrc-6 2 3 unspecified role unspecified role unspecified role unspecified role Region 20-698 Region 20-698 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P02787:p.[Asn432Asp;Tyr445Phe;Tyr536Phe;Asn630Asp] Y426F/Y517F/N413D/N611D mutation mutation certain certain sequence position certain certain certain sequence position certain N D certain certain sequence position certain certain certain sequence position certain Y F certain certain sequence position certain certain certain sequence position certain Y F certain certain sequence position certain certain certain sequence position certain N D Wed May 02 15:43:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn432asp,tyr445phe,tyr536phe,asn630asp' Tue Jun 30 17:48:22 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Asn432Asp;Tyr445Phe;Tyr536Phe;Asn630Asp]' hamsters Cricetinae 4 unspecified role unspecified role unspecified role unspecified role Region 121-760 Region 121-760 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain hamsters Cricetinae direct interaction direct interaction