DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Nature structural & molecular biology 2011 imex curation Batchelor JD., Zahm JA., Tolia NH. Only protein-protein interactions in vitro In vitro saxs x ray scattering saxs predetermined predetermined participant predetermined Batchelor JD., Zahm JA., Tolia NH. DIP original experiment: DIP-218649X Nature structural & molecular biology 2011 IMEx Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Nature structural & molecular biology 2011 imex curation Batchelor JD., Zahm JA., Tolia NH. Only protein-protein interactions in vitro In vitro saxs x ray scattering saxs predetermined predetermined participant predetermined Batchelor JD., Zahm JA., Tolia NH. DIP original experiment: DIP-218646X Nature structural & molecular biology 2011 IMEx Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Nature structural & molecular biology 2011 imex curation Batchelor JD., Zahm JA., Tolia NH. Only protein-protein interactions in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Batchelor JD., Zahm JA., Tolia NH. DIP original experiment: DIP-218645X Nature structural & molecular biology 2011 IMEx Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Nature structural & molecular biology 2011 imex curation Batchelor JD., Zahm JA., Tolia NH. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Batchelor JD., Zahm JA., Tolia NH. DIP original experiment: DIP-218648X Nature structural & molecular biology 2011 IMEx Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. Nature structural & molecular biology 2011 imex curation Batchelor JD., Zahm JA., Tolia NH. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Batchelor JD., Zahm JA., Tolia NH. DIP original experiment: DIP-218647X Nature structural & molecular biology 2011 IMEx Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC. q16570-1 Atypical chemokine receptor 1 ACKR1 DARC FY GPD Duffy antigen/chemokine receptor Fy glycoprotein Glycoprotein D Plasmodium vivax receptor protein protein human Homo sapiens Human MGNCLHRAELSPSTENSSQLDFEDVWNSSYGVNDSFPDGDYGANLEAAAPCHSCNLLDDSALPFFILTSVLGILASSTVLFMLFRPLFRWQLCPGWPVLAQLAVGSALFSIVVPVLAPGLGSTRSSALCSLGYCVWYGSAFAQALLLGCHASLGHRLGAGQVPGLTLGLTVGIWGVAALLTLPVTLASGASGGLCTLIYSTELKALQATHTVACLAIFVLLPLGLFGAKGLKKALGMGPGPWMNILWAWFIFWWPHGVVLGLDFLVRSKLLLLSTCLAQQALDLLLNLAEALAILHCVATPLLLALFCHQATRTLLPSLPLPEGWSSHLDTLGSKS DIP protein Q16570-1 original sequence version: 110 pvdr_plavs Duffy receptor PVDR Erythrocyte-binding protein protein protein Plasmodium vivax (strain Salvador I) Plasmodium vivax (strain Salvador I) MKGKNRSLFVLLVLLLLHKVNNVLLERTIETLLECKNEYVKGENGYKLAKGHHCVEEDNLERWLQGTNERRSEENIKYKYGVTELKIKYAQMNGKRSSRILKESIYGAHNFGGNSYMEGKDGGDKTGEEKDGEHKTDSKTDNGKGANNLVMLDYETSSNGQPAGTLDNVLEFVTGHEGNSRKNSSNGGNPYDIDHKKTISSAIINHAFLQNTVMKNCNYKRKRRERDWDCNTKKDVCIPDRRYQLCMKELTNLVNNTDTNFHRDITFRKLYLKRKLIYDAAVEGDLLLKLNNYRYNKDFCKDIRWSLGDFGDIIMGTDMEGIGYSKVVENNLRSIFGTDEKAQQRRKQWWNESKAQIWTAMMYSVKKRLKGNFIWICKLNVAVNIEPQIYRWIREWGRDYVSELPTEVQKLKEKCDGKINYTDKKVCKVPPCQNACKSYDQWITRKKNQWDVLSNKFISVKNAEKVQTAGIVTPYDILKQELDEFNEVAFENEINKRDGAYIELCVCSVEEAKKNTQEVVTNVDNAAKSQATNSNPISQPVDSSKAEKVPGDSTHGNVNSGQDSSTTGKAVTGDGQNGNQTPAESDVQRSDIAESVSAKNVDPQKSVSKRSDDTASVTGIAEAGKENLGASNSRPSESTVEANSPGDDTVNSASIPVVSGENPLVTPYNGLRHSKDNSDSDGPAESMANPDSNSKGETGKGQDNDMAKATKDSSNSSDGTSSATGDTTDAVDREINKGVPEDRDKTVGSKDGGGEDNSANKDAATVVGEDRIRENSAGGSTNDRSKNDTEKNGASTPDSKQSEDATALSKTESLESTESGDRTTNDTTNSLENKNGGKEKDLQKHDFKSNDTPNEEPNSDQTTDAEGHDRDSIKNDKAERRKHMNKDTFTKNTNSHHLNSNNNLSNGKLDIKEYKYRDVKATREDIILMSSVRKCNNNISLEYCNSVEDKISSNTCSREKSKNLCCSISDFCLNYFDVYSYEYLSCMKKEFEDPSYKCFTKGGFKDKTYFAAAGALLILLLLIASRKMIKNDSEEATFNEFEEYCDNIHRIPLMPNNIEHMQPSTPLDYS DIP protein P22290 original sequence version: 55 ackr1-pvdr-1 5 6 unspecified role unspecified role unspecified role unspecified role Region 1-60 Region 1-60 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 7 unspecified role unspecified role unspecified role unspecified role Region 211-525 Region 211-525 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ackr1-pvdr-2 3 6 unspecified role unspecified role unspecified role unspecified role Region 1-60 Region 1-60 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 7 unspecified role unspecified role unspecified role unspecified role Region 211-525 Region 211-525 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction pvdr-1 4 7 unspecified role unspecified role unspecified role unspecified role Region 211-525 Region 211-525 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ackr1-pvdr-3 2 6 unspecified role unspecified role unspecified role unspecified role Region 1-60 Region 1-60 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 7 unspecified role unspecified role unspecified role unspecified role Region 211-525 Region 211-525 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction pvdr-2 1 7 unspecified role unspecified role unspecified role unspecified role Region 211-525 Region 211-525 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction