DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218541X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions in vitro In vitro ms of complexes mass spectrometry studies of complexes ms of complexes predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218549X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli tem transmission electron microscopy tem predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218544X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218542X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218539X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218538X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli tem transmission electron microscopy tem predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218545X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli saxs x ray scattering saxs predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218550X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli tem transmission electron microscopy tem predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218546X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218543X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions in vitro In vitro ms of complexes mass spectrometry studies of complexes ms of complexes predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218548X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli ms of complexes mass spectrometry studies of complexes ms of complexes predetermined predetermined participant predetermined Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218547X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature structural & molecular biology 2011 imex curation Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. Only protein-protein interactions ecolx Escherichia coli pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Jore MM., Lundgren M., van Duijn E., Bultema JB., Westra ER., Waghmare SP., Wiedenheft B., Pul U., Wurm R., Wagner R., Beijer MR., Barendregt A., Zhou K., Snijders AP., Dickman MJ., Doudna JA., Boekema EJ., Heck AJ., van der Oost J., Brouns SJ. DIP original experiment: DIP-218540X Nature structural & molecular biology 2011 IMEx Structural basis for CRISPR RNA-guided DNA recognition by Cascade. cse1_ecoli CRISPR system Cascade subunit CasA casA cse1 ygcL JW2730 b2760 CRISPR type I-E/Ecoli-associated protein CasA/Cse1 CRISPR-associated protein CasA/Cse1 protein protein ecoli Escherichia coli (strain K12) MNLLIDNWIPVRPRNGGKVQIINLQSLYCSRDQWRLSLPRDDMELAALALLVCIGQIIAPAKDDVEFRHRIMNPLTEDEFQQLIAPWIDMFYLNHAEHPFMQTKGVKANDVTPMEKLLAGVSGATNCAFVNQPGQGEALCGGCTAIALFNQANQAPGFGGGFKSGLRGGTPVTTFVRGIDLRSTVLLNVLTLPRLQKQFPNESHTENQPTWIKPIKSNESIPASSIGFVRGLFWQPAHIELCDPIGIGKCSCCGQESNLRYTGFLKEKFTFTVNGLWPHPHSPCLVTVKKGEVEEKFLAFTTSAPSWTQISRVVVDKIIQNENGNRVAAVVNQFRNIAPQSPLELIMGGYRNNQASILERRHDVLMFNQGWQQYGNVINEIVTVGLGYKTALRKALYTFAEGFKNKDFKGAGVSVHETAERHFYRQSELLIPDVLANVNFSQADEVIADLRDKLHQLCEMLFNQSVAPYAHHPKLISTLALARATLYKHLRELKPQGGPSNG DIP protein Q46901 original sequence version: 58 DIP protein Q46901 original sequence version: 61 DIP protein Q46901 original sequence version: 85 DIP protein Q46901 original sequence version: 82 DIP protein Q46901 original sequence version: 92 B3ACC755ABE8D965 cas5_ecoli CRISPR system Cascade subunit CasD casD cas5 ygcI b2757 JW5844 protein protein ecoli Escherichia coli (strain K12) MRSYLILRLAGPMQAWGQPTFEGTRPTGRFPTRSGLLGLLGACLGIQRDDTSSLQALSESVQFAVRCDELILDDRRVSVTGLRDYHTVLGAREDYRGLKSHETIQTWREYLCDASFTVALWLTPHATMVISELEKAVLKPRYTPYLGRRSCPLTHPLFLGTCQASDPQKALLNYEPVGGDIYSEESVTGHHLKFTARDEPMITLPRQFASREWYVIKGGMDVSQ DIP protein Q46898 original sequence version: 63 DIP protein Q46898 original sequence version: 66 DIP protein Q46898 original sequence version: 89 DIP protein Q46898 original sequence version: 86 DIP protein Q46898 original sequence version: 96 1C42CC009B317D68 cse2_ecoli CRISPR system Cascade subunit CasB casB cse2 ygcK JW2729 b2759 protein protein ecoli Escherichia coli (strain K12) MADEIDAMALYRAWQQLDNGSCAQIRRVSEPDELRDIPAFYRLVQPFGWENPRHQQALLRMVFCLSAGKNVIRHQDKKSEQTTGISLGRALANSGRINERRIFQLIRADRTADMVQLRRLLTHAEPVLDWPLMARMLTWWGKRERQQLLEDFVLTTNKNA DIP protein P76632 original sequence version: 57 DIP protein P76632 original sequence version: 60 DIP protein P76632 original sequence version: 83 DIP protein P76632 original sequence version: 80 DIP protein P76632 original sequence version: 90 F2493AAD46595E5C cas6_ecoli CRISPR system Cascade subunit CasE casE CasE endoRNase cas6e crRNA endonuclease ygcH JW2726 b2756 protein protein ecoli Escherichia coli (strain K12) MYLSKVIIARAWSRDLYQLHQGLWHLFPNRPDAARDFLFHVEKRNTPEGCHVLLQSAQMPVSTAVATVIKTKQVEFQLQVGVPLYFRLRANPIKTILDNQKRLDSKGNIKRCRVPLIKEAEQIAWLQRKLGNAARVEDVHPISERPQYFSGDGKSGKIQTVCFEGVLTINDAPALIDLVQQGIGPAKSMGCGLLSLAPL DIP protein Q46897 original sequence version: 61 DIP protein Q46897 original sequence version: 65 DIP protein Q46897 original sequence version: 94 DIP protein Q46897 original sequence version: 91 DIP protein Q46897 original sequence version: 101 1D5C060DD5FCAFAD casc_ecoli CRISPR system Cascade subunit CasC casC cas4 cse4 ygcJ JW2728 b2758 protein protein ecoli Escherichia coli (strain K12) MSNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKSGYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGKSVDEAEKISADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIRVNLQQGVDIALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFTAVDDLQEQGSAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIATHVVHMLATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGFLQPSIQAFNQYWDRVANGYGLNGAAAQFSLSDVDPITAQVKQMPTLEQLKSWVRNNGEA DIP protein Q46899 original sequence version: 61 DIP protein Q46899 original sequence version: 64 DIP protein Q46899 original sequence version: 90 DIP protein Q46899 original sequence version: 86 DIP protein Q46899 original sequence version: 97 D9A99E0CBBD2B956 casa-casb-1 1 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 18 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 16 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 14 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association casb-casa-1 6 17 unspecified role unspecified role prey prey ecolx Escherichia coli 15 unspecified role unspecified role prey prey ecolx Escherichia coli 18 unspecified role unspecified role prey prey ecolx Escherichia coli 16 unspecified role unspecified role bait bait StrepII-tag StrepII-tag strep ii tag strep ii tag Strep (II) Strep II Strep (II) Strep II n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 14 unspecified role unspecified role prey prey ecolx Escherichia coli association association casa-casb-2 3 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 18 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 16 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 14 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association casb-casc-1 7 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 18 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 16 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association casb-casc-2 4 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 18 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 16 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association casb-casc-3 11 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 18 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 16 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association casb-casc-4 5 17 unspecified role unspecified role prey prey ecolx Escherichia coli 15 unspecified role unspecified role prey prey ecolx Escherichia coli 18 unspecified role unspecified role prey prey ecolx Escherichia coli 16 unspecified role unspecified role bait bait StrepII-tag StrepII-tag strep ii tag strep ii tag Strep (II) Strep II Strep (II) Strep II n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli association association casc-casd-1 9 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 18 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association casb-1 2 16 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction casc-casd-2 13 17 unspecified role unspecified role prey prey ecolx Escherichia coli 15 unspecified role unspecified role prey prey ecolx Escherichia coli 18 unspecified role unspecified role bait bait StrepII-tag StrepII-tag strep ii tag strep ii tag Strep (II) Strep II Strep (II) Strep II n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli association association casc-casd-3 10 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 18 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association casa-casb-3 12 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 18 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 16 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 14 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association casa-casb-4 8 17 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 18 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 16 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 14 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association