DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E. Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Tait S., Dutta K., Cowburn D., Warwicker J., Doig AJ., McCarthy JE. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Tait S., Dutta K., Cowburn D., Warwicker J., Doig AJ., McCarthy JE. DIP original experiment: DIP-220039X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E. Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E. Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Tait S., Dutta K., Cowburn D., Warwicker J., Doig AJ., McCarthy JE. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Tait S., Dutta K., Cowburn D., Warwicker J., Doig AJ., McCarthy JE. DIP original experiment: DIP-220038X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E. if4e_human Eukaryotic translation initiation factor 4E mRNA cap-binding protein eIF-4F 25 kDa subunit EIF4E EIF4EL1 EIF4F protein protein human Homo sapiens Human MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV DIP protein P06730 original sequence version: 164 DIP protein P06730 original sequence version: 127 DIP protein P06730 original sequence version: 126 DIP protein P06730 original sequence version: 135 DIP protein P06730 original sequence version: 151 DIP protein P06730 original sequence version: 155 DIP protein P06730 original sequence version: 160 DIP protein P06730-1 original sequence version: 187 DIP protein P06730 original sequence version: 146 B869B8DE615E699D 4ebp1_human Eukaryotic translation initiation factor 4E-binding protein 1 Phosphorylated heat- and acid-stable protein regulated by insulin 1 EIF4EBP1 protein protein human Homo sapiens Human MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI DIP protein Q13541 original sequence version: 96 DIP protein Q13541 original sequence version: 103 DIP protein Q13541 original sequence version: 120 DIP protein Q13541 original sequence version: 113 1682A6BA74132966 eif4e-eif4ebp1-15 2 3 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 4 unspecified role unspecified role unspecified role unspecified role eIF4E-binding domain Region 51-67 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q13541:p.Asp55Ser D55S mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D S This feature has been corrected as a result of our quality control procedures. The original label was 'D55S'. Wed May 02 17:17:32 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp55ser' Tue Jun 30 19:42:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp55Ser' Q13541:p.Lys57Glu K57E mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K57E'. Wed May 02 17:31:15 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys57glu' Tue Jun 30 15:43:32 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys57Glu' Q13541:p.[Lys57Glu;Glu61Gly] K57E/E61G mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain E G certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K57E/E61G'. Wed May 02 15:37:26 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys57glu,glu61gly' Tue Jun 30 17:54:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys57Glu;Glu61Gly]' Q13541:p.Met60Thr M60/T/A/E mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain M T Wed May 02 16:32:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'met60thr' Tue Jun 30 16:17:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Met60Thr' Q13541:p.Glu61Lys E61K mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain E K This feature has been corrected as a result of our quality control procedures. The original label was 'E61K'. Wed May 02 17:17:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu61lys' Tue Jun 30 16:54:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu61Lys' Q13541:p.Asn64Ser N64S mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain N S This feature has been corrected as a result of our quality control procedures. The original label was 'N64S'. Wed May 02 19:56:14 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn64ser' Tue Jun 30 19:28:22 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn64Ser' Q13541:p.Arg63Gln R63Q mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R Q This feature has been corrected as a result of our quality control procedures. The original label was 'R63Q'. Wed May 02 15:37:05 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg63gln' Tue Jun 30 16:42:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg63Gln' Q13541:p.Met60Ala mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain M A Wed May 02 17:27:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'met60ala' Tue Jun 30 18:40:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Met60Ala' Q13541:p.Met60Glu mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain M E Wed May 02 15:04:14 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'met60glu' Tue Jun 30 15:55:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Met60Glu' in vitro In vitro direct interaction direct interaction eif4e-eif4ebp1-16 1 3 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 4 unspecified role unspecified role unspecified role unspecified role eIF4E-binding domain Region 51-67 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro direct interaction direct interaction