DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Du J., Wei Y., Liu L., Wang Y., Khairova R., Blumenthal R., Tragon T., Hunsberger JG., Machado-Vieira R., Drevets W., Wang YT., Manji HK. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Du J., Wei Y., Liu L., Wang Y., Khairova R., Blumenthal R., Tragon T., Hunsberger JG., Machado-Vieira R., Drevets W., Wang YT., Manji HK. DIP original experiment: DIP-219843X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Du J., Wei Y., Liu L., Wang Y., Khairova R., Blumenthal R., Tragon T., Hunsberger JG., Machado-Vieira R., Drevets W., Wang YT., Manji HK. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Du J., Wei Y., Liu L., Wang Y., Khairova R., Blumenthal R., Tragon T., Hunsberger JG., Machado-Vieira R., Drevets W., Wang YT., Manji HK. DIP original experiment: DIP-219842X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Du J., Wei Y., Liu L., Wang Y., Khairova R., Blumenthal R., Tragon T., Hunsberger JG., Machado-Vieira R., Drevets W., Wang YT., Manji HK. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Du J., Wei Y., Liu L., Wang Y., Khairova R., Blumenthal R., Tragon T., Hunsberger JG., Machado-Vieira R., Drevets W., Wang YT., Manji HK. DIP original experiment: DIP-219845X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Du J., Wei Y., Liu L., Wang Y., Khairova R., Blumenthal R., Tragon T., Hunsberger JG., Machado-Vieira R., Drevets W., Wang YT., Manji HK. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Du J., Wei Y., Liu L., Wang Y., Khairova R., Blumenthal R., Tragon T., Hunsberger JG., Machado-Vieira R., Drevets W., Wang YT., Manji HK. DIP original experiment: DIP-219844X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. gria2_rat Glutamate receptor 2 Gria2 Glur2 GluR-B GluR-K2 Glutamate receptor ionotropic, AMPA 2 AMPA-selective glutamate receptor 2 protein protein rat Rattus norvegicus (Rat) Rat MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI DIP protein P19491 original sequence version: 164 DIP protein P19491 original sequence version: 160 DIP protein P19491 original sequence version: 131 DIP protein P19491 original sequence version: 136 DIP protein P19491 original sequence version: 141 DEFA817027C1CCD1 gsk3b_rat Glycogen synthase kinase-3 beta Gsk3b Serine/threonine-protein kinase GSK3B Factor A protein protein rat Rattus norvegicus (Rat) Rat MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST DIP protein P18266 original sequence version: 122 mint homomint Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN 2F473FCAB89B4398 peptide2 Phosphoglycogen synthase peptide-2 peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) YRRAAVPPSPSLSRHSSPHQSEDEEE b2gv74_rat Kinesin light chain Klc2 Klc2_predicted rCG_48462 protein protein rat Rattus norvegicus (Rat) Rat MATMVLPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLASHEAGEAEPGSQERCLLLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDSLDDLFPNEDEQSPAPSPGGGDVAAQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGENKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRSRKQGLDPASQTKVVELLKDGSGGRGDRRGSRDVAGGAGPRSESDLEESGPAAEWSGDGSGSLRRSGSFGKLRDALRRSSEMLVRKLQGGGPQEPPNSRMKRASSLNFLNKSVEEPVQPGGTGLSDSRTLSSSSMDLSRRSSLVG DIP protein B2GV74 original sequence version: 22 9198A0A0043DE3B5 tatklcpcdk TAT-KLCpCDK peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) YGRKKRRQRRRLSDSRTLSSSSMDLSRRSSLVG gria1_rat Glutamate receptor 1 Gria1 GluR-A GluR-K1 Glutamate receptor ionotropic, AMPA 1 AMPA-selective glutamate receptor 1 Glur1 protein protein rat Rattus norvegicus (Rat) Rat MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGATGL DIP protein P19490 original sequence version: 146 DIP protein P19490 original sequence version: 142 DIP protein P19490 original sequence version: 117 DIP protein P19490 original sequence version: 127 DIP protein P19490 original sequence version: 131 DIP protein P19490 original sequence version: 129 2D4CFA7CCD532838 klc2-gria1-1 2 5 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 10 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 8 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat association association gsk3b-peptide2-1 3 6 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli 7 enzyme target enzyme target substrate substrate unspecified role unspecified role in vitro In vitro phosphorylation phosphorylation reaction phosphorylation klc2-gria1-2 1 10 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 8 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat physical association physical association gsk3b-tatklcpcdk-1 4 6 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli 9 enzyme target enzyme target substrate substrate unspecified role unspecified role in vitro In vitro phosphorylation phosphorylation reaction phosphorylation