DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. Structure (London, England : 1993) 2010 imex curation Peterson FC., Baden EM., Owen BA., Volkman BF., Ramirez-Alvarado M. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Peterson FC., Baden EM., Owen BA., Volkman BF., Ramirez-Alvarado M. DIP original experiment: DIP-216141X Structure (London, England : 1993) 2010 IMEx A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. Structure (London, England : 1993) 2010 imex curation Peterson FC., Baden EM., Owen BA., Volkman BF., Ramirez-Alvarado M. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Peterson FC., Baden EM., Owen BA., Volkman BF., Ramirez-Alvarado M. DIP original experiment: DIP-216142X Structure (London, England : 1993) 2010 IMEx A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. Structure (London, England : 1993) 2010 imex curation Peterson FC., Baden EM., Owen BA., Volkman BF., Ramirez-Alvarado M. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Peterson FC., Baden EM., Owen BA., Volkman BF., Ramirez-Alvarado M. DIP original experiment: DIP-216143X Structure (London, England : 1993) 2010 IMEx A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. kv133_human Immunoglobulin kappa variable 1-33 IGKV1-33 Ig kappa chain V-I region AU Ig kappa chain V-I region Ka protein protein human Homo sapiens Human MDMRVPAQLLGLLLLWLSGARCDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDNLP DIP protein P01594 original sequence version: 71 igkv1_33-1 1 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction igkv1_33-2 2 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction igkv1_33-3 3 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction