DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Benseñor LB., Barlan K., Rice SE., Fehon RG., Gelfand VI. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly pull down pull down western blot western blot Immuno blot Immuno blot Benseñor LB., Barlan K., Rice SE., Fehon RG., Gelfand VI. DIP original experiment: DIP-219701X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Benseñor LB., Barlan K., Rice SE., Fehon RG., Gelfand VI. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Benseñor LB., Barlan K., Rice SE., Fehon RG., Gelfand VI. DIP original experiment: DIP-219702X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Benseñor LB., Barlan K., Rice SE., Fehon RG., Gelfand VI. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly pull down pull down western blot western blot Immuno blot Immuno blot Benseñor LB., Barlan K., Rice SE., Fehon RG., Gelfand VI. DIP original experiment: DIP-219700X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Benseñor LB., Barlan K., Rice SE., Fehon RG., Gelfand VI. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Benseñor LB., Barlan K., Rice SE., Fehon RG., Gelfand VI. DIP original experiment: DIP-219703X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. kinh_drome Kinesin heavy chain Khc kin CG7765 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MSAEREIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSGQGAIAIRGGGAVGGPSPLAQVNPVNS DIP protein P17210 original sequence version: 100 DIP protein P17210 original sequence version: 103 24840EF414790888 merh_drome Moesin/ezrin/radixin homolog 2 Mer EMR2 CG14228 Ezrin-moesin-radixin 2 Merlin protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MSPFGSKKNRSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL DIP protein Q24564 original sequence version: 91 940D6B8A0D160A3F dyhc_drome Dynein heavy chain, cytoplasmic Dhc64C cDhc CG7507 Dynein heavy chain, cytosolic protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MGDSLENPDTSVDPIVNLSIANYDAFANYLRKAVTILLPEDDVVPASLNDALDDPVNQDTIRKFLSDPQVQALYVQRNCIKEDDSEQPAEGEDEKEQVTYQISNDVHFTNSRMASLACIKRGLVVEADKSIHSQLRLINFSDGSPYETLHAFISKSLAPYFKSYVKESGRADRDGDKMAPSVEKKLAELEMGLLHLQQNIDIPEITLTAHQTVNNVIRKCAEENRKAKVADFGDKVEDSSFLNLLQNGVNRWIAEIKKVTKLNRDPGSGTALQEISFWLNLERALYRIQEKRESPEVALTLDILKHGKRFHATVSFDTDTGLKQALATVADYNPLMKDFPINDLLSATELEKIRPAVQQIFAHLRKVRNTKYPIQRCLKLIEAISRDLSQQLLKVLGTRRLMHIPFDEFERVMNQCFEIFSCWDDEYDKLQGLLRDIVKKKRDEHLKMVWRVSPAHKKLQTRMEHMRKFRRQHEQLRTVILRVLRPTKPAVGDDGNVVETKQPYSLDAADANAIEEVNLAYENVKEVDCLDITKEGSEAWEAAVKRYEEKIDRVETRITAHLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIEALHEKFKVQYPQSKSCRLSSVRDLPPVAGSIIWARQIDNQLTMYLKRVEDVLGKGWETHIEGQKLKADGDSFRAKLSISDVFHEWARKVQERNFGSTGRIFTIESTRSRIGRGNVLRLRVNFLPEIITLAKEVRNIKNLGFRVPLTIVNKAHQANQIYPYAISLIESVRTYERTLEKIEDRASIVPLVAGLRKDVLNLVSEGIGLIWESYKLDPYVIRLSECVTQFQEKVDDLLVVEEQLDVDVRSLETCPYSAATFVEILSKIQHAVDDLSLRQYSNLSVWVTRLDEEVEKKLALRLQAGIQAWTEALTGNKKEVDTSMDTDAPAQPTHKLGGDPQIQNAVHEIRITNQQMYLYPSIEEARFQIMQQFFAWQAIVTSQVRLQSTRYQVGLEKHVSQTYRNLLTKLPEGKILENAYGAIEQKVSEVRNYVDEWLRYQSLWDLQADMLYGRLGEDVNLWIKCLNDIKQSRTTFDTSDTRRAYGPIIIDYAKVQAKVTLKYDSWHKEALGKFGTLLGTEMTSFHSKVSKSRTDLEMQSIEAASTSDAVSFITYVQSLKKDMIAWDKQVEVFREAQRILERQRFQFPNTWLHVDNIEGEWSAFNEIIKRKDTAIQTQVASLQAKIVAEDKAVETRTVDFLNDWEKTKPTGGKIRPDDALQQLQIFESKYSRLKEERDNVVKAKEALELQESAVPNNSAERMNVALEELQDLRGVWSELSKVWTQIDETREKPWLSVQPRKLRQQLEAMMAQLKELPARLRMYESYEYVKKLIQSYIKVNMLIVELKSDALKERHWKQLTKQLRVNWVLSDLSLGQVWDVNLQKNEGIVKDIILVAQGEMALEEFLKQVRESWQNYELDLINYQNKCRIIRGWDDLFNKVKEHINSVAAMKLSPYYKVFEEEALTWEEKLNRINALFDVWIDVQRRWVYLEGIFSGSADIKTLLPVETSRFQSISSEFLGLMKKVTKSPKVMDVLNIPAVQRSLERLADLLGKIQKALGEYLERERTSFPRFYFVGDEDLLEIIGNSKNIARLQKHFKKMFAGVAAILLNEENNVILGISSREGEEVHFMNPVSTVEHPKINEWLSLVEKQMRFTLASLLAQAVQDIKQFRDGKIDPQAYMEWCDKYQAQIVVLAAQILWSEDVESALQQASENNQSKPMQRVLGNVESTLNVLADSVLQEQPPLRRRKLEHLINEFVHKRTVTRRLLNNGVTSPKSFQWLCEMRFYFDPRQTEVLQQLTIHMANARFFYGFEYLGVQDRLVQTPLTDRCYLTMTQALESRLGGSPFGPAGTGKTESVKALGNQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSACSQQIQTIQEALKYEMDSNKESITVELVGKQVRVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTTPDRQLIAEVMLFSQGFRSAEKLACKIVPFFKLCDEQLSNQSHYDFGLRALKSVLISAGNVKRDRIMKIKEQMKQRGDENIDEASVAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPNVGYTRAEMKGLKEEIRKVCQEDYLVCGEGDEQGAAWMEKVLQLYQISNLNHGLMMVGPSGSGKSTAWKTLLKALERFEGVEGVAHVIDPKAISKEALYGVLDPNTREWTDGLFTHILRKIIDNVRGEINKRQWIIFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRVMFEVQDLKFATLATVSRCGMVWFSEDVLSTEMIFENYLSRLRSIPLEDGDEDFVGVIKPAKDKEEEVSPSLQVQRDIALLLLPFFSADGIVVRTLEYAMDQEHIMDFTRLRALSSLFSMLNQAARNVLTFNAQHPDFPCSADQLEHYIPKALVYSVLWSFAGDAKLKVRIDLGDFVRSVTTVPLPGAAGAPIIDYEVNMSGDWVPWSNKVPVIEVETHKVASPDIVVPTLDTVRHESLLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRKTPNGVVLSPVQIGKWLVLFCDEINLPDMDSYGTQRVISFLRQLVEHKGFYRASDQAWVSLERIQFVGACNPPTDPGRKPLSHRFLRHVPIIYVDYPGETSLKQIYGTFSRAMLRLMPALRGYAEPLTNAMVEFYLASQDRFTQDMQPHYVYSPREMTRWVRGICEAIRPLDSLPVEGLVRLWAHEALRLFQDRLVDDSERRWTNENIDLVGQKHFPGINQEEALQRPILYSNWLSKDYMPVNREELREYVHARLKVFYEEELDVPLVLFDEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNKYTSEDFDEDLRCVLRRSGCKDEKIAFILDESNVLDSGFLERMNTLLANGEVPGLFEGDEYTTLMTQCKEGAQREGLMLDSSDELYKWFTQQVMRNLHVVFTMNPSTDGLKDRAATSPALFNRCVLNWFGDWSDSALFQVGKEFTTRVDLEKPNWHAPDFFPSVCPLVPANPTHRDAVINSCVYVHQTLHQANARLAKRGGRTMAVTPRHYLDFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVMADLAQVEPAVIDAQAAVKSIRKQQLVEVRTMANPPSVVKLALESICLLLGENATDWKSIRAVIMRENFINSIVSNFGTENITDDVREKMKSKYLSNPDYNFEKVNRASMACGPMVKWAIAQIEYADMLKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRSIALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAAFIAYGGYFDQHYRLNLFTTWSQHLQAASIQYRADIARTEYLSNPDERLRWQANALPTDDLCTENAIMLKRFNRYPLIIDPSGQATTFLLNEYAGKKITKTSFLDDSFRKNLESALRFGNPLLVQDVENYDPILNPVLNRELRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDICSRVTFVNFTVTRSSLQSQCLNQVLKAERPDIDEKRSDLLKLQGEFRLRLRQLEKSLLQALNDAKGKILDDDSVITTLETLKKEAYDINQKVDETDKVIAEIETVSQQYLPLSVACSNIYFTMDSLNQVHFLYQYSLKMFLDIFSTVLYNNPKLEGRTDHSERLGIVTRDLFQVCYERVARGMIHIDRLTFALLMCKIHLKGTSESNLDAEFNFFLRSREGLLANPTPVEGLSAEQIESVNRLALRLPIFRKLLEKVRSIPELGAWLQQSSPEQVVPQLWDESKALSPIASSVHQLLLIQAFRPDRVIAAAHNVVNTVLGEDFMPNAEQELDFTSVVDKQLNCNTPALLCSVPGFDASGRVDDLAAEQNKQISSIAIGSAEGFNQAERAINMACKTGRWVLLKNVHLAPQWLVQLEKKMHSLQPHSGFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGIRANLLRTFSTVPAARMMKTPSERARLYFLLAWFHAIVQERLRYVPLGWAKKYEFNESDLRVACDTLDTWIDTTAMGRTNLPPEKVPWDALVTLLSQSIYGGKIDNDFDQRLLTSFLKKLFTARSFEADFALVANVDGASGGLRHITMPDGTRRDHFLKWIENLTDRQTPSWLGLPNNAEKVLLTTRGTDLVSKLLKMQQLEDDDELAYSVEDQSEQSAVGRGEDGRPSWMKTLHNSATAWLELLPKNLQVLKRTVENIKDPLYRYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPAGCTVIQWITDFSNRVQQLQKVSQLVSQAGAKELQGFPVWLGGLLNPEAYITATRQCVAQANSWSLEELALDVTITDAGLKNDQKDCCFGVTGLKLQGAQCKNNELLLASTIMMDLPVTILKWIKISSEPRISKLTLPVYLNSTRTELLFTVDLAVAAGQESHSFYERGVAVLTSTALN DIP protein P37276 original sequence version: 97 2A3D4F1F8BE52096 mer-mer-7 3 6 unspecified role unspecified role prey prey drome Drosophila melanogaster (Fruit fly) Fruit fly 6 unspecified role unspecified role bait bait GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association mer-dhc64c-1 2 7 unspecified role unspecified role prey prey drome Drosophila melanogaster (Fruit fly) Fruit fly 5 unspecified role unspecified role prey prey drome Drosophila melanogaster (Fruit fly) Fruit fly 6 unspecified role unspecified role bait bait drome Drosophila melanogaster (Fruit fly) Fruit fly association association mer-dhc64c-2 1 7 unspecified role unspecified role prey prey drome Drosophila melanogaster (Fruit fly) Fruit fly 5 unspecified role unspecified role prey prey drome Drosophila melanogaster (Fruit fly) Fruit fly 6 unspecified role unspecified role bait bait GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q24564:p.Lys70Glu K70E mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K70E'. Wed May 02 17:26:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys70glu' Tue Jun 30 16:33:21 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys70Glu' drome Drosophila melanogaster (Fruit fly) Fruit fly association association mer-dhc64c-3 4 7 unspecified role unspecified role prey prey drome Drosophila melanogaster (Fruit fly) Fruit fly 5 unspecified role unspecified role prey prey drome Drosophila melanogaster (Fruit fly) Fruit fly 6 unspecified role unspecified role bait bait GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q24564:p.Thr616Asp T616D mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain T D This feature has been corrected as a result of our quality control procedures. The original label was 'T616D'. Wed May 02 18:04:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr616asp' Tue Jun 30 18:18:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr616Asp' drome Drosophila melanogaster (Fruit fly) Fruit fly association association