DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome. Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Jang H., Arce FT., Ramachandran S., Capone R., Azimova R., Kagan BL., Nussinov R., Lal R., Jang H., Arce FT., Ramachandran S., Capone R., Azimova R., Kagan BL., Nussinov R., Lal R. Alzheimers - Interactions investigated in the context of Alzheimers disease Only protein-protein interactions in vitro In vitro atomic force microsc atomic force microscopy AFM AFM atomic force microsc predetermined predetermined participant predetermined Jang H., Arce FT., Ramachandran S., Capone R., Azimova R., Kagan BL., Nussinov R., Lal R. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-220960X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome. p05067-pro_0000000092 Amyloid-beta protein 42 Alzheimer disease amyloid protein Cerebral vascular amyloid peptide APP A4 AD1 ABPP PreA4 Protease nexin-II APPI Amyloid precursor protein Amyloid-beta A4 protein Alzheimer disease amyloid A4 protein homolog Amyloid-beta (A4) precursor protein protein protein human Homo sapiens Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 672 713 3AC85563D7858C37 abeta142-5 1 2 unspecified role unspecified role unspecified role unspecified role p3 peptide Region 17-42 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 2 unspecified role unspecified role unspecified role unspecified role p3 peptide Region 17-42 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro direct interaction direct interaction