DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Chianale F., Rainero E., Cianflone C., Bettio V., Pighini A., Porporato PE., Filigheddu N., Serini G., Sinigaglia F., Baldanzi G., Graziani A. Only protein-protein interactions canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Chianale F., Rainero E., Cianflone C., Bettio V., Pighini A., Porporato PE., Filigheddu N., Serini G., Sinigaglia F., Baldanzi G., Graziani A. DIP original experiment: DIP-254204X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. rac1_canlf Ras-related C3 botulinum toxin substrate 1 RAC1 p21-Rac1 Rac2 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL DIP protein P62999 original sequence version: 66 mint Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles ACEDF83A45E5EA67 f1pl93_canlf ARHGDIA protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNVVVTRLTLVCSTAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKNDDKTDHLSWEWNLTIKKEWKD DIP protein F1PL93 original sequence version: 19 5F15A25C3E2AE7BE arhgdia-rac1-8 1 2 unspecified role unspecified role prey prey canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris 3 unspecified role unspecified role bait bait canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris physical association physical association