DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nature structural & molecular biology 2010 imex curation Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. DIP original experiment: DIP-216953X Nature structural & molecular biology 2010 IMEx Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nature structural & molecular biology 2010 imex curation Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. Only protein-protein interactions ecolx Escherichia coli light scattering light scattering predetermined predetermined participant predetermined Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. DIP original experiment: DIP-216951X Nature structural & molecular biology 2010 IMEx Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nature structural & molecular biology 2010 imex curation Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. DIP original experiment: DIP-216954X Nature structural & molecular biology 2010 IMEx Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nature structural & molecular biology 2010 imex curation Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. DIP original experiment: DIP-216950X Nature structural & molecular biology 2010 IMEx Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nature structural & molecular biology 2010 imex curation Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Chao LH., Pellicena P., Deindl S., Barclay LA., Schulman H., Kuriyan J. DIP original experiment: DIP-216952X Nature structural & molecular biology 2010 IMEx Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. ck2n1_rat Calcium/calmodulin-dependent protein kinase II inhibitor 1 Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor alpha protein protein rat Rattus norvegicus (Rat) Rat MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQSKRPPKLGQIGRSKRVVIEDDRIDDVLKTMTDKAPPGV DIP protein Q9JI15 original sequence version: 37 calm_chick Calmodulin CALM CAM RCJMB04_24e7 protein protein chick Gallus gallus (Chicken) Chicken MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK DIP protein P62149 original sequence version: 32 DIP protein P62149 original sequence version: 64 6B4BC3FCDE10727B kcc2d_caeel Calcium/calmodulin-dependent protein kinase type II unc-43 Uncoordinated protein 43 K11E8.1 protein protein caeel Caenorhabditis elegans MMNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDTVDCLKKFNARRKLKAAISAVKMVTRMSGVLRTSDSTGSVASNGSTTHDASQVAGTSSQPTSPAAEVYPNVLLFNPQKFPRNCVHPFTTHPYYSPKESSKKKLFFTLLFEVCPHTSRSHILLRDNTKNIYHPYHCFTNKMSNYERAAPSSHGSSTTKKIANAIADLVIRRSSPSIRRKTEADVHNSNRNRKVSAPANLQHALVPVIDVVVATGALASSSVDNLSASTSSDLGRNLLNKKEQGPPSTIKESSESSQTIDDNDSEKGGGQLKHENTVVRADGATGIVSSSNSSTASKSSSTNLSAQKQDIVRVTQTLLDAISCKDFETYTRLCDTSMTCFEPEALGNLIEGIEFHRFYFDGNRKNQVHTTMLNPNVHIIGEDAACVAYVKLTQFLDRNGEAHTRQSQESRVWSKKQGRWVCVHVHRSTQPSTNTTVSEF This sequence has been withdrawn from Uniprot. 3231366FFF81A695 3231366FFF81A695 camkii-2 4 8 unspecified role unspecified role unspecified role unspecified role Kinase and regulatory R1 domain Region 1-291 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction calm-camkii-1 1 7 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 8 unspecified role unspecified role unspecified role unspecified role Kinase and regulatory domain Region 1-340 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction camkii-3 2 8 unspecified role unspecified role unspecified role unspecified role Kinase and regulatory R1 domain Region 1-291 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction camk2n1-camkii-1 5 6 unspecified role unspecified role unspecified role unspecified role inhibitory domain Region 42-62 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 8 unspecified role unspecified role unspecified role unspecified role Kinase domain Region 1-272 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction camkii-4 3 8 unspecified role unspecified role unspecified role unspecified role Kinase and regulatory R1 domain Region 1-289 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction