DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133644X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133654X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133655X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133648X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133652X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133640X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133658X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133656X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133649X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133650X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133645X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133646X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133657X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133647X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133641X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133653X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133643X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133651X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 imex curation Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Schwickart M., Huang X., Lill JR., Liu J., Ferrando R., French DM., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang DC., Dixit VM. DIP original experiment: DIP-133642X Nature 2010 IMEx Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. mcl1_human Induced myeloid leukemia cell differentiation protein Mcl-1 Bcl-2-related protein EAT/mcl1 mcl1/EAT MCL1 BCL2L3 Bcl-2-like protein 3 protein protein human Homo sapiens Human MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR DIP protein Q07820 original sequence version: 85 DIP protein Q07820 original sequence version: 89 DIP protein Q07820 original sequence version: 113 DIP protein Q07820 original sequence version: 168 DIP protein Q07820-1 original sequence version: 113 D85821AC59275F1F usp9x_human Probable ubiquitin carboxyl-terminal hydrolase FAF-X USP9X DFFRX USP9 Ubiquitin-specific-processing protease FAF-X Deubiquitinating enzyme FAF-X Fat facets protein-related, X-linked Ubiquitin-specific protease 9, X chromosome FAM Fat facets in mammals Ubiquitin thioesterase FAF-X protein protein human Homo sapiens Human MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQLEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRYISELAITTRPHQIIMPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ DIP protein Q93008 original sequence version: 163 DIP protein Q93008 original sequence version: 105 16B87B7FCC1428AF ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG ubp2_rat Ubiquitin carboxyl-terminal hydrolase 2 Usp2 41 kDa ubiquitin-specific protease Deubiquitinating enzyme 2 Ubiquitin thioesterase 2 Ubiquitin-specific-processing protease 2 Ubiquitin-specific-processing protease testis Ubp41 Ubp69 protein protein rat Rattus norvegicus (Rat) Rat MSQLSSTLKRYTESSRYTDAPYAKSGYGTYTPSSYGANLAASFLEKEKLGFKPVSPTSFLPRPRTYGPSSILDCDRGRPLLRSDITGGSKRSESQTRGNERPSGSGLNGGSGFPYGVTSNSLSYLPMNARDQGVTLGQKKSNSQSDLARDFSSLRTSDSYRTSDGYRASDGFRIDPGNLGRSPMLARTRKELCALQGLYQAASRSEYLTDYLENYGRKGSAPQVLTQAPPSRVPEVLSPTYRPSGRYTLWEKNKGQASGPSRSTSPGRDTMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAHTALMEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVAARPKPSPESLDHLPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPVTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM This sequence has been withdrawn from Uniprot. B8B2091192CA4944 bak_human Bcl-2 homologous antagonist/killer Apoptosis regulator BAK Bcl-2-like protein 7 BAK1 BAK BCL2L7 CDN1 protein protein human Homo sapiens Human MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS DIP protein Q16611 original sequence version: 74 DIP protein Q16611 original sequence version: 162 DIP protein Q16611 original sequence version: 97 DIP protein Q16611 original sequence version: 158 DIP protein Q16611 original sequence version: 151 DIP protein Q16611-1 original sequence version: 178 DIP protein Q16611-1 original sequence version: 180 DIP protein Q16611 original sequence version: 121 A2200FE72A46D04E huwe1_human E3 ubiquitin-protein ligase HUWE1 HECT, UBA and WWE domain-containing protein 1 Upstream regulatory element-binding protein 1 Mcl-1 ubiquitin ligase E3 ARF-binding protein 1 Large structure of UREB1 Homologous to E6AP carboxyl terminus homologous protein 9 HUWE1 KIAA0312 KIAA1578 HSPC272 HECT-type E3 ubiquitin transferase HUWE1 UREB1 protein protein human Homo sapiens Human MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVMLTLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESRDGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCIETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETNCESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGETSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEERPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA DIP protein Q7Z6Z7 original sequence version: 83 DIP protein Q7Z6Z7 original sequence version: 89 FA9D3A7712F6393B mcl1-ub-1 1 22 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal human Homo sapiens Human 20 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association mcl1-huwe1-2 6 25 unspecified role unspecified role prey prey human Homo sapiens Human 21 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human association association mcl1-usp2-1 7 23 enzyme enzyme unspecified role unspecified role 20 enzyme target enzyme target substrate substrate unspecified role unspecified role Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range Poly-Ub Poly-Ub xlnk-n6lys-1gly N6-glycyl-L-lysine (2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid N6-(glycyl)-L-lysine N6-glycyllysine XLNK-N6Lys-1Gly CROSSLNK Glycyl lysine isopeptide (Gly-Lys) (interchain with K-...) CROSSLNK Glycyl lysine isopeptide (Lys-Gly) (interchain with G-...) western blot western blot Immuno blot Immuno blot undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined MCL1 is polyubiquitinated. human Homo sapiens Human deubiquitination deubiquitination reaction deubiquitination mcl1-huwe1-3 4 25 unspecified role unspecified role prey prey human Homo sapiens Human 21 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human association association mcl1-bak1-9 5 24 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait human Homo sapiens Human 21 unspecified role unspecified role prey prey human Homo sapiens Human association association mcl1-ub-2 2 22 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association mcl1-ub-3 11 22 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association mcl1-huwe1-4 15 25 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait human Homo sapiens Human 21 unspecified role unspecified role prey prey human Homo sapiens Human association association ub-usp9x-1 13 22 enzyme target enzyme target substrate substrate unspecified role unspecified role Poly-Ub Poly-Ub xlnk-n6lys-1gly N6-glycyl-L-lysine (2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid N6-(glycyl)-L-lysine N6-glycyllysine XLNK-N6Lys-1Gly CROSSLNK Glycyl lysine isopeptide (Gly-Lys) (interchain with K-...) CROSSLNK Glycyl lysine isopeptide (Lys-Gly) (interchain with G-...) western blot western blot Immuno blot Immuno blot undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Polyubiquitin is used in the experiment. ecolx Escherichia coli 21 enzyme enzyme unspecified role unspecified role Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q93008:p.Cys1566Ser C1566S mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain C S This feature has been corrected as a result of our quality control procedures. The original label was 'C1566S'. Wed May 02 16:38:56 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys1566ser' Tue Jun 30 19:50:37 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys1566Ser' human Homo sapiens Human deubiquitination deubiquitination reaction deubiquitination mcl1-bak1-10 16 24 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association mcl1-huwe1-5 9 25 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range N-terminal truncation Region 169-350 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human physical association physical association mcl1-usp9x-1 12 21 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range in vitro In vitro 20 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range in vitro In vitro direct interaction direct interaction usp9x-huwe1-1 19 25 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role prey prey human Homo sapiens Human 21 unspecified role unspecified role bait bait human Homo sapiens Human association association ub-mcl1-1 3 22 unspecified role unspecified role bait bait human Homo sapiens Human 20 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association mcl1-usp9x-2 10 20 unspecified role unspecified role bait bait human Homo sapiens Human 21 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association usp9x-mcl1-1 14 21 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range in vitro In vitro 20 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range in vitro In vitro direct interaction direct interaction huwe1-mcl1-3 17 25 unspecified role unspecified role bait bait human Homo sapiens Human 20 unspecified role unspecified role prey prey human Homo sapiens Human 21 unspecified role unspecified role prey prey human Homo sapiens Human association association mcl1-usp9x-3 18 21 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range Q07820:p.[Ser155Asp;Ser159Asp;Thr163Asp] S155D/S159D/T163D mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain T D certain certain sequence position certain certain certain sequence position certain S D certain certain sequence position certain certain certain sequence position certain S D This feature has been corrected as a result of our quality control procedures. The original label was 'S155D/S159D/T163D'. Wed May 02 19:34:27 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser155asp,ser159asp,thr163asp' Tue Jun 30 16:25:53 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser155Asp;Ser159Asp;Thr163Asp]' human Homo sapiens Human physical association physical association mcl1-usp9x-4 8 21 enzyme enzyme unspecified role unspecified role Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q93008:p.Cys1566Ser C1566S mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain C S This feature has been corrected as a result of our quality control procedures. The original label was 'C1566S'. Wed May 02 17:23:08 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys1566ser' Tue Jun 30 19:41:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys1566Ser' human Homo sapiens Human 20 enzyme target enzyme target substrate substrate unspecified role unspecified role Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range Poly-Ub Poly-Ub xlnk-n6lys-1gly N6-glycyl-L-lysine (2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid N6-(glycyl)-L-lysine N6-glycyllysine XLNK-N6Lys-1Gly CROSSLNK Glycyl lysine isopeptide (Gly-Lys) (interchain with K-...) CROSSLNK Glycyl lysine isopeptide (Lys-Gly) (interchain with G-...) western blot western blot Immuno blot Immuno blot undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined MCL1 is polyubiquitinated. human Homo sapiens Human deubiquitination deubiquitination reaction deubiquitination