DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Choi MK., Wang Z., Ban T., Yanai H., Lu Y., Koshiba R., Nakaima Y., Hangai S., Savitsky D., Nakasato M., Negishi H., Takeuchi O., Honda K., Akira S., Tamura T., Taniguchi T. Only protein-protein interactions mouse Mus musculus Mouse comig non denat gel comigration in non denaturing gel electrophoresis comig non denat gel western blot western blot Immuno blot Immuno blot Choi MK., Wang Z., Ban T., Yanai H., Lu Y., Koshiba R., Nakaima Y., Hangai S., Savitsky D., Nakasato M., Negishi H., Takeuchi O., Honda K., Akira S., Tamura T., Taniguchi T. DIP original experiment: DIP-216108X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. irf3_mouse Interferon regulatory factor 3 Irf3 protein protein mouse Mus musculus Mouse METPKPRILPWLVSQLDLGQLEGVAWLDESRTRFRIPWKHGLRQDAQMADFGIFQAWAEASGAYTPGKDKPDVSTWKRNFRSALNRKEVLRLAADNSKDPYDPHKVYEFVTPGARDFVHLGASPDTNGKSSLPHSQENLPKLFDGLILGPLKDEGSSDLAIVSDPSQQLPSPNVNNFLNPAPQENPLKQLLAEEQWEFEVTAFYRGRQVFQQTLFCPGGLRLVGSTADMTLPWQPVTLPDPEGFLTDKLVKEYVGQVLKGLGNGLALWQAGQCLWAQRLGHSHAFWALGEELLPDSGRGPDGEVHKDKDGAVFDLRPFVADLIAFMEGSGHSPRYTLWFCMGEMWPQDQPWVKRLVMVKVVPTCLKELLEMAREGGASSLKTVDLHISNSQPISLTSDQYKAYLQDLVEDMDFQATGNI DIP protein P70671 original sequence version: 63 DIP protein P70671 original sequence version: 84 DIP protein P70671 original sequence version: 78 mint homomint Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains 1FF67C4E0FC7F027 irf3-7 1 2 unspecified role unspecified role unspecified role unspecified role mouse Mus musculus Mouse physical association physical association