DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Richardson BC., Smith RD., Ungar D., Nakamura A., Jeffrey PD., Lupashin VV., Hughson FM. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Richardson BC., Smith RD., Ungar D., Nakamura A., Jeffrey PD., Lupashin VV., Hughson FM. DIP original experiment: DIP-134402X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Richardson BC., Smith RD., Ungar D., Nakamura A., Jeffrey PD., Lupashin VV., Hughson FM. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Richardson BC., Smith RD., Ungar D., Nakamura A., Jeffrey PD., Lupashin VV., Hughson FM. DIP original experiment: DIP-134403X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Richardson BC., Smith RD., Ungar D., Nakamura A., Jeffrey PD., Lupashin VV., Hughson FM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Richardson BC., Smith RD., Ungar D., Nakamura A., Jeffrey PD., Lupashin VV., Hughson FM. DIP original experiment: DIP-134404X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. q9h9e3-1 Conserved oligomeric Golgi complex subunit 4 Component of oligomeric Golgi complex 4 COG4 protein protein human Homo sapiens Human MADLDSPPKLSGVQQPSEGVGGGRCSEISAELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL DIP protein Q9H9E3-1 original sequence version: 80 cog6_human Conserved oligomeric Golgi complex subunit 6 COG6 KIAA1134 Component of oligomeric Golgi complex 6 protein protein human Homo sapiens Human MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQAAKEQTQDLIVKTTKLQSESQKLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETAYERLYRWAQSECRTLTQESCDVSPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTTQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIVGNSATALLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLMLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASNLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRVGLSYIYNTVQQHKPEQGSLANMPNLDSVTLKAAMVQFDRYLSAPDNLLIPQLNFLLSATVKEQIVKQSTELVCRAYGEVYAAVMNPINEYKDPENILHRSPQQVQTLLS DIP protein Q9Y2V7 original sequence version: 72 0F29785E722B5185 cog4-1 1 4 unspecified role unspecified role unspecified role unspecified role Region 525-785 Region 525-785 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cog4-2 2 4 unspecified role unspecified role unspecified role unspecified role Region 525-785 Region 525-785 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cog6-cog4-1 3 5 unspecified role unspecified role bait bait human Homo sapiens Human 4 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Region 1-524 Region 1-524 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human physical association physical association