DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009 imex curation Wang Y., Vera L., Fischer WH., Montminy M. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang Y., Vera L., Fischer WH., Montminy M. DIP original experiment: DIP-249942X Nature 2009 IMEx The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009 imex curation Wang Y., Vera L., Fischer WH., Montminy M. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Wang Y., Vera L., Fischer WH., Montminy M. DIP original experiment: DIP-249947X Nature 2009 IMEx The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009 imex curation Wang Y., Vera L., Fischer WH., Montminy M. Only protein-protein interactions in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Wang Y., Vera L., Fischer WH., Montminy M. DIP original experiment: DIP-249946X Nature 2009 IMEx The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009 imex curation Wang Y., Vera L., Fischer WH., Montminy M. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wang Y., Vera L., Fischer WH., Montminy M. DIP original experiment: DIP-249948X Nature 2009 IMEx The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009 imex curation Wang Y., Vera L., Fischer WH., Montminy M. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip ms participant Identification by mass spectrometry ms participant Wang Y., Vera L., Fischer WH., Montminy M. DIP original experiment: DIP-249944X Nature 2009 IMEx The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009 imex curation Wang Y., Vera L., Fischer WH., Montminy M. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wang Y., Vera L., Fischer WH., Montminy M. DIP original experiment: DIP-249945X Nature 2009 IMEx The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009 imex curation Wang Y., Vera L., Fischer WH., Montminy M. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang Y., Vera L., Fischer WH., Montminy M. DIP original experiment: DIP-249943X Nature 2009 IMEx The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. crtc2_human CREB-regulated transcription coactivator 2 TORC2 Transducer of regulated cAMP response element-binding protein 2 CRTC2 protein protein human Homo sapiens Human MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGSGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYTRHIDSSPYSPAYLSPPPESSWRRTMAWGNFPAEKGQLFRLPSALNRTSSDSALHTSVMNPSPQDTYPGPTPPSILPSRRGGILDGEMDPKVPAIEENLLDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGNSTSNLTHTMTHLGISRGMGLGPGYDAPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLARHVLPTTSLGHPSLSAPALSSSSSSSSTSSPVLGAPSYPASTPGASPHHRRVPLSPLSLLAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLSTDQRLPPYPYSSPSLVLPTQPHTPKSLQQPGLPSQSCSVQSSGGQPPGRQSHYGTPYPPGPSGHGQQSYHRPMSDFNLGNLEQFSMESPSASLVLDPPGFSEGPGFLGGEGPMGGPQDPHTFNHQNLTHCSRHGSGPNIILTGDSSPGFSKEIAAALAGVPGFEVSAAGLELGLGLEDELRMEPLGLEGLNMLSDPCALLPDPAVEESFRSDRLQ DIP protein Q53ET0 original sequence version: 54 DIP protein Q53ET0 original sequence version: 1(def) DIP protein Q53ET0 original sequence version: 50 EE6C52E0ECDC1DF1 atf6a_mouse Cyclic AMP-dependent transcription factor ATF-6 alpha Atf6 Activating transcription factor 6 alpha protein protein mouse Mus musculus Mouse MESPFSPVLPHGPDEDWESTLFAELGYFTDTDDVHFDAAHEAYENNFDHLNFDLDLMPWESDLWSPGSHFCSDMKAEPQPLSPASSSCSISSPRSTDSCSSTQHVPEELDLLSSSQSPLSLYGDSCNSPSSVEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPAAPKTQTNASVPAKAIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPTVVQLQSPAVLSSAQPVLAVTGGAAQLPNHVVNVLPAPVVSSPVNGKLSVTKPVLQSATRSMGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDEVVSENQRLKVPSPKRRAVCVMIVLAFIMLNYGPMSMLEQESRRVKPSVSPANQRRHLLEFSAKEVKDTSDGDNQKDSYSYDHSVSNDKALMVLSEEPLLYMPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNSQQKARILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPGSYQGFFDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTTTETTHVVSTIPESLQ This sequence has been withdrawn from Uniprot. C3ADCF7DF2CB3EC9 C3ADCF7DF2CB3EC9 atf6a_human Cyclic AMP-dependent transcription factor ATF-6 alpha Activating transcription factor 6 alpha ATF6 protein protein human Homo sapiens Human MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNLDFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKTENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTVVQLQAPGVLPSAQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYGPMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVSTIPESLQ DIP protein P18850 original sequence version: 117 DIP protein P18850 original sequence version: 127 DIP protein P18850 original sequence version: 130 5EBD08CF4121D41A crtc2_mouse CREB-regulated transcription coactivator 2 Torc2 Crtc2 Transducer of regulated cAMP response element-binding protein 2 protein protein mouse Mus musculus Mouse MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDARRMVSPLRRYPRHIDSSPYSPAYLSPPPESGWRRMMPWGNLPAEKGQLFRLPSALNRTSSDSALHTSVMNPNPQDTYPGPTPPSVLPSRRGGGFLDGEMDAKVPAIEENVVDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTHLGISGGLGLGPSYDVPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLAHHALPTTSLGHPSLSAPALSSSSSSSSTSSPVLSAPPYPASTPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLPTDQRLPPYPYSPPSLVIPTHPPTPKSLQQLPSQACLVQPSGGQPPGRQPHYGALYPPGSSGHGQQPYHRPINDFSLGNLEQFNMESPSTSLVLDPPAFSEGPGFLGSEGSMSGPQDPHVLNHQNLTHCSRHGSGPNIILTGDSSPGFSKEIAAALAGVPGFEVSASGLELGLGLEDELRMEPLGLEGLTMLSDPCALLPDPAVEDSFRSDRLQ DIP protein Q3U182 original sequence version: 23 DIP protein Q3U182 original sequence version: 54 DIP protein Q3U182 original sequence version: 64 DIP protein Q3U182 original sequence version: 52 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells mint 5BCBC416D45CFAD8 crtc2-matf6alpha-1 1 11 unspecified role unspecified role bait bait mouse Mus musculus Mouse 9 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association crtc2-atf6-1 6 10 unspecified role unspecified role prey prey Region 1-381 Region 1-381 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 8 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association crtc2-atf6-2 2 10 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 8 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association matf6alpha-crtc2-1 7 11 unspecified role unspecified role prey prey mouse Mus musculus Mouse 9 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association crtc2-atf6-3 4 11 unspecified role unspecified role bait bait mouse Mus musculus Mouse 10 unspecified role unspecified role prey prey Region 1-381 Region 1-381 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain mouse Mus musculus Mouse physical association physical association crtc2-atf6-4 3 11 unspecified role unspecified role bait bait Region 1-120 Region 1-120 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 10 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association crtc2-atf6-5 5 10 unspecified role unspecified role prey prey human Homo sapiens Human 8 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association