DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro pull down pull down ms participant Identification by mass spectrometry ms participant Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132340X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132347X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132341X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro peptide array peptide array predetermined predetermined participant predetermined Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132345X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132349X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132346X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro peptide array peptide array predetermined predetermined participant predetermined Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132343X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132348X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132342X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (London, England : 1993) 2009 imex curation Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. Only protein-protein interactions in vitro In vitro peptide array peptide array predetermined predetermined participant predetermined Harkiolaki M., Tsirka T., Lewitzky M., Simister PC., Joshi D., Bird LE., Jones EY., O'Reilly N., Feller SM. DIP original experiment: DIP-132344X Structure (London, England : 1993) 2009 IMEx Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. ubp8_human Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-specific-processing protease 8 Deubiquitinating enzyme 8 USP8 KIAA0055 UBPY Ubiquitin isopeptidase Y Ubiquitin thioesterase 8 protein protein human Homo sapiens Human MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT DIP protein P40818 original sequence version: 110 DIP protein P40818 original sequence version: 139 DIP protein P40818 original sequence version: 127 8B884B7A842F9A9A ptn23_mouse Tyrosine-protein phosphatase non-receptor type 23 Ptpn23 Kiaa1471 protein protein mouse Mus musculus Mouse MEAVPRMPMIWLDLKEAGDFHFQSAVKKFVLKNYGENPEAYNEELKKLELLRQNAIRVARDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVAVTWTEIFSGKSVSHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAFSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFAMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMLAKIEDKNEVLDQFMDSMQLDPETVDNLDAYNHIPPQLMEKCAALSVRPDTVKNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELQEQKLQETLGQAGAGPGPSVAKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALTPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDNVLRALTEANVQYAAVRRVLSELDQKWNSTLQTLVASYEAYEDLMKKSQEGKDFYADLESKVATLLERAQSICRAQEAARQQLLDRELKKKAPPPRPTAPKPLLSRREEGEAVEAGDTPEELRSLPPDMMVGPRLPDPFLGTTAPLHFSPGPFPSSTGPATHYLSGPLPPGTYSGPTQLMQPRAAVPMAPATVLYPAPAYTSELGLVPRSSPQHGIVSSPYAGVGPPQPVVGLPSAPPPQLSGPELAMTVRPATTTVDSVQAPISSHTAPRPNPTPALPQPCFPVPQPVPQSVPQPQPLPVPYTYSIGTKQPLPAPYTYSIGTKQHLTGPLPQHQFPPGIPTGFPVPRTGPQAQAQPQPQPQPQPQPQPQPQPQPQPQSQSQPQPQPQPQPQRPAFGPQPTQQPLPFQHPHLFPSQAPGILPPPPPTPYHFTPQPGVLGQPPPTLHTQLYPGPSQDPLPPHSGALPFPSPGPPHPHPTLAYGPAPSPRPLGPQATPVSIRGPPPASQPTPSPHLVPSPAPSPGPGPVPSRPPTAEPPPCLRRGAAAADLLSSSPESQHGGTQPPGGGQPLLQPTKVDAAEGRRPQALRLIEQDPYEHPERLQQLQQELEAFRGQLGDAGALDAIWRELQEAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSVALSSIRTTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPGNLLRFIQEVHAHYLHQRPLHTPIVVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLKFCHEALVRHVEQVLQRHGVPPPGKPVASVNISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPLGGLDSPAASLPGLVEPPGLPPASLPESTPVPSSSPPPLSSPLPEAPQPEEEPSVPEAPSLGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKQNFLQAHNGQGLRAAQPTDDPLSLLDPLWTLNKT DIP protein Q6PB44 original sequence version: 58 331363C917E9C4D2 cdn1b_human Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor p27 p27Kip1 CDKN1B KIP1 protein protein human Homo sapiens Human MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT DIP protein P46527 original sequence version: 120 DIP protein P46527 original sequence version: 115 DIP protein P46527 original sequence version: 154 DIP protein P46527 original sequence version: 168 DIP protein P46527 original sequence version: 164 DIP protein P46527 original sequence version: 118 1118D58901CDF3FC ptn23_human Tyrosine-protein phosphatase non-receptor type 23 His domain-containing protein tyrosine phosphatase Protein tyrosine phosphatase TD14 PTPN23 KIAA1471 protein protein human Homo sapiens Human MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPSDDPLSLLDPLWTLNKT DIP protein Q9H3S7 original sequence version: 55 DIP protein Q9H3S7 original sequence version: 74 DIP protein Q9H3S7 original sequence version: 89 536BDDF9D3DC95C0 dyn2_human Dynamin-2 DNM2 DYN2 protein protein human Homo sapiens Human MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD DIP protein P50570 original sequence version: 149 DIP protein P50570 original sequence version: 100 DIP protein P50570 original sequence version: 160 2F4567B75980935D p62993-1 Growth factor receptor-bound protein 2 GRB2 ASH Adapter protein GRB2 Protein Ash SH2/SH3 adapter GRB2 Ash-L protein protein human Homo sapiens Human MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV DIP protein P62993-1 original sequence version: 88 DIP protein P62993 original sequence version: 100 DIP protein P62993 original sequence version: 132 DIP protein P62993 original sequence version: 154 DIP protein P62993-1 original sequence version: 45 q9uqc2-1 GRB2-associated-binding protein 2 GAB2 KIAA0571 GRB2-associated binder 2 Growth factor receptor bound protein 2-associated protein 2 pp100 protein protein human Homo sapiens Human MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL DIP protein Q9UQC2-1 original sequence version: 69 lcp2_human Lymphocyte cytosolic protein 2 LCP2 SH2 domain-containing leukocyte protein of 76 kDa SLP-76 tyrosine phosphoprotein protein protein human Homo sapiens Human MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP DIP protein Q13094 original sequence version: 141 DIP protein Q13094 original sequence version: 98 DIP protein Q13094 original sequence version: 113 C5D22F31D36200C8 cbl_human E3 ubiquitin-protein ligase CBL Signal transduction protein CBL Proto-oncogene c-Cbl Casitas B-lineage lymphoma proto-oncogene RING finger protein 55 CBL CBL2 RNF55 RING-type E3 ubiquitin transferase CBL protein protein human Homo sapiens Human MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT DIP protein P22681 original sequence version: 173 DIP protein P22681 original sequence version: 128 DIP protein P22681 original sequence version: 145 DIP protein P22681 original sequence version: 150 DIP protein P22681 original sequence version: 191 DIP protein P22681 original sequence version: 91 DIP protein P22681 original sequence version: 139 1AA6BF67377322CA grap2_mouse GRB2-related adaptor protein 2 GADS protein Growth factor receptor-binding protein GRBLG GRB-2-like protein Hematopoietic cell-associated adaptor protein GrpL GRB-2-related monocytic adapter protein Adapter protein GRID Grap2 Gads Grb2l Grid Mona protein protein mouse Mus musculus Mouse MEATAKFDFMASGEDELSFRTGDILKILSNQEEWLKAELGSQEGYVPKNFIDIEFPEWFHEGLSRHQAENLLMGKDIGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDTKGNYFLWTEKFPSLNKLVDYYRTTSISKQKQVFLRDGTQDQGHRGNSLDRRSQGGPHPSGTVGEEIRPSVNRKLSDHLPLGPQQFHPHQQPSPQFTPGPQPPQQQRYLQHFHQDRRGGSLDINDGHCGLGSEVNATLMHRRHTDPVQLQAAGRVRWARALYDFEALEEDELGFRSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMMR DIP protein O89100 original sequence version: 91 736311D0640CD3D0 cd2ap_human CD2-associated protein CD2AP Cas ligand with multiple SH3 domains Adapter protein CMS protein protein human Homo sapiens Human MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS DIP protein Q9Y5K6 original sequence version: 92 DIP protein Q9Y5K6 original sequence version: 94 DIP protein Q9Y5K6 original sequence version: 98 7576509C7ED5B343 grap2-cbl-2 1 14 unspecified role unspecified role prey prey human Homo sapiens Human 15 unspecified role unspecified role prey prey human Homo sapiens Human 18 unspecified role unspecified role prey prey human Homo sapiens Human 21 unspecified role unspecified role prey prey human Homo sapiens Human 19 unspecified role unspecified role prey prey human Homo sapiens Human 11 unspecified role unspecified role prey prey human Homo sapiens Human 20 unspecified role unspecified role bait bait Region 265-322 Region 265-322 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli association association gab2-grb2-2 8 17 unspecified role unspecified role unspecified role unspecified role Region 350-361 Region 350-361 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Region 508-522 Region 508-522 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Q9UQC2-1:p.[Arg515Ala;Lys518Ala] R515A/K518A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R515A/K518A'. Wed May 02 18:54:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg515ala,lys518ala' Tue Jun 30 18:02:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg515Ala;Lys518Ala]' Q9UQC2-1:p.Pro511Ala P511A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P511A'. Wed May 02 20:33:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro511ala' Tue Jun 30 20:25:02 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro511Ala' Q9UQC2-1:p.Arg515Ala R515A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R515A'. Wed May 02 18:33:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg515ala' Tue Jun 30 19:43:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg515Ala' Q9UQC2-1:p.Lys518Ala K518A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K A This feature has been corrected as a result of our quality control procedures. The original label was 'K518A'. Wed May 02 19:20:25 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys518ala' Tue Jun 30 18:49:45 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys518Ala' Q9UQC2-1:p.Arg354Ala R354A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R354A'. Wed May 02 16:32:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg354ala' Tue Jun 30 19:12:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg354Ala' Q9UQC2-1:p.Lys357Ala K357A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K A This feature has been corrected as a result of our quality control procedures. The original label was 'K357A'. Wed May 02 16:31:08 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys357ala' Tue Jun 30 18:05:51 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys357Ala' in vitro In vitro 16 unspecified role unspecified role unspecified role unspecified role Region 159-214 Region 159-214 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction grap2-ptpn23-2 3 12 unspecified role unspecified role unspecified role unspecified role Region 719-732 Region 719-732 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 20 unspecified role unspecified role unspecified role unspecified role Region 265-322 Region 265-322 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ptpn23-grap2-4 4 14 unspecified role unspecified role bait bait Region 708-734 Region 708-734 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 20 unspecified role unspecified role prey prey Region 265-322 Region 265-322 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli direct interaction direct interaction grap2-ptpn23-3 6 14 unspecified role unspecified role unspecified role unspecified role Region 708-734 Region 708-734 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 20 unspecified role unspecified role unspecified role unspecified role Region 265-322 Region 265-322 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cdkn1b-grb2-1 5 13 unspecified role unspecified role unspecified role unspecified role Region 84-98 Region 84-98 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 16 unspecified role unspecified role unspecified role unspecified role Region 159-214 Region 159-214 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction gab2-grb2-3 7 17 unspecified role unspecified role bait bait Region 351-358 Region 351-358 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Region 510-519 Region 510-519 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 16 unspecified role unspecified role prey prey Region 159-214 Region 159-214 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli direct interaction direct interaction gab2-grb2-4 9 17 unspecified role unspecified role unspecified role unspecified role Region 341-367 Region 341-367 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Region 502-528 Region 502-528 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 16 unspecified role unspecified role unspecified role unspecified role Region 159-214 Region 159-214 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ptpn23-grap2-5 10 12 unspecified role unspecified role bait bait Region 710-737 Region 710-737 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 20 unspecified role unspecified role prey prey Region 265-322 Region 265-322 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli direct interaction direct interaction grap2-ptpn23-4 2 12 unspecified role unspecified role unspecified role unspecified role Region 719-731 Region 719-731 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Q6PB44:p.Arg722Ala R722A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R722A'. Wed May 02 18:29:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg722ala' Tue Jun 30 15:37:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg722Ala' Q6PB44:p.Lys727Ala K727A/H mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K A Wed May 02 14:50:43 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys727ala' Tue Jun 30 19:20:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys727Ala' Q6PB44:p.Lys727_Pro728delinsAlaAla K727A/P728A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain KP AA Wed May 02 20:01:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys_pro727-728ala_ala' Tue Jun 30 17:53:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys727_Pro728delinsAlaAla' Q6PB44:p.[Pro720Ala;Arg722Ala] P720A/R722A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R A certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P720A/R722A'. Wed May 02 16:47:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro720ala,arg722ala' Tue Jun 30 20:16:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Pro720Ala;Arg722Ala]' Q6PB44:p.Lys727His mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain K H Wed May 02 19:25:06 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys727his' Tue Jun 30 19:53:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys727His' in vitro In vitro 20 unspecified role unspecified role unspecified role unspecified role Region 265-322 Region 265-322 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction