DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134117X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134116X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134120X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions in vitro In vitro pull down pull down weight by staining molecular weight estimation by staining weight by staining Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134119X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134124X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134122X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134125X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134121X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions in vitro In vitro pull down pull down weight by staining molecular weight estimation by staining weight by staining Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134123X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Fu J., Bian M., Liu J., Jiang Q., Zhang C. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Fu J., Bian M., Liu J., Jiang Q., Zhang C. DIP original experiment: DIP-134118X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. aurka_human Aurora kinase A AIRK1 Serine/threonine-protein kinase 15 Aurora/IPL1-related kinase 1 Breast tumor-amplified kinase STK6 AIK ARK1 AURA BTAK STK15 AURKA AYK1 IAK1 Aurora 2 Serine/threonine-protein kinase 6 Serine/threonine-protein kinase aurora-A protein protein human Homo sapiens Human MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS DIP protein O14965 original sequence version: 181 DIP protein O14965 original sequence version: 146 DIP protein O14965 original sequence version: 124 DIP protein O14965 original sequence version: 160 DIP protein O14965 original sequence version: 138 DIP protein O14965 original sequence version: 98 125F3594834CD157 aurkb_human Aurora kinase B AIRK2 Aurora- and IPL1-like midbody-associated protein 1 Aurora/IPL1-related kinase 2 STK-1 Serine/threonine-protein kinase 12 Serine/threonine-protein kinase 5 STK1 STK5 Aurora 1 AURKB AIK2 AIM1 ARK2 STK12 Serine/threonine-protein kinase aurora-B protein protein human Homo sapiens Human MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA DIP protein Q96GD4 original sequence version: 88 DIP protein Q96GD4 original sequence version: 113 DIP protein Q96GD4 original sequence version: 116 DIP protein Q96GD4 original sequence version: 122 DIP protein Q96GD4 original sequence version: 177 DIP protein Q96GD4-1 original sequence version: 177 A5ED13EF5A1FAFBF tpx2_human Targeting protein for Xklp2 TPX2 C20orf1 C20orf2 DIL2 HCA519 Restricted expression proliferation-associated protein 100 Differentially expressed in cancerous and non-cancerous lung cells 2 Protein fls353 Hepatocellular carcinoma-associated antigen 519 Hepatocellular carcinoma-associated antigen 90 protein protein human Homo sapiens Human MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVSPKFSTRFHC DIP protein Q9ULW0 original sequence version: 104 DIP protein Q9ULW0 original sequence version: 112 This sequence has been withdrawn from Uniprot. E028E0BB50BBCA0F q9nqs7-1 Inner centromere protein INCENP protein protein human Homo sapiens Human MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQGARVPSSLAYSLKKH DIP protein Q9NQS7-1 original sequence version: 83 birc5_human Baculoviral IAP repeat-containing protein 5 Apoptosis inhibitor survivin Apoptosis inhibitor 4 BIRC5 API4 IAP4 protein protein human Homo sapiens Human MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD DIP protein O15392 original sequence version: 129 DIP protein O15392 original sequence version: 132 DIP protein O15392-1 original sequence version: 141 DIP protein O15392-1 original sequence version: 143 9E7CADCDF2822286 ince_human Inner centromere protein INCENP protein protein human Homo sapiens Human MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQGARVPSSLAYSLKKH DIP protein Q9NQS7 original sequence version: 83 DIP protein Q9NQS7 original sequence version: 86 644D081DCC9035E8 aurka-tpx2-1 2 13 unspecified role unspecified role prey prey human Homo sapiens Human 11 unspecified role unspecified role bait bait O14965:p.Gly198Asn G198N mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain G N This feature has been corrected as a result of our quality control procedures. The original label was 'G198N'. Wed May 02 17:18:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly198asn' Wed May 02 20:28:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly198asn' Tue Jun 30 19:14:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly198Asn' GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association aurka-incenp-1 3 14 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 826-918 Region 826-918 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 11 enzyme enzyme unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm phosphorylation phosphorylation reaction phosphorylation aurkb-birc5-4 10 16 unspecified role unspecified role prey prey human Homo sapiens Human 15 unspecified role unspecified role prey prey human Homo sapiens Human 12 unspecified role unspecified role bait bait GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human association association aurka-incenp-2 6 16 unspecified role unspecified role prey prey human Homo sapiens Human 11 unspecified role unspecified role bait bait O14965:p.Gly198Ala G198A/V/L mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain G A Wed May 02 19:50:18 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly198ala' Tue Jun 30 17:16:23 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly198Ala' GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range O14965:p.Gly198Val mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain G V Wed May 02 20:19:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly198val' Tue Jun 30 19:45:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly198Val' O14965:p.Gly198Leu mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain G L Wed May 02 14:57:45 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly198leu' Tue Jun 30 16:55:03 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly198Leu' human Homo sapiens Human physical association physical association aurkb-birc5-5 7 12 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli 15 enzyme target enzyme target substrate substrate unspecified role unspecified role ecolx Escherichia coli phosphorylation phosphorylation reaction phosphorylation aurkb-incenp-2 5 12 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli 14 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 826-918 Region 826-918 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli phosphorylation phosphorylation reaction phosphorylation aurka-birc5-1 8 15 enzyme target enzyme target substrate substrate unspecified role unspecified role ecolx Escherichia coli 11 enzyme enzyme unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm phosphorylation phosphorylation reaction phosphorylation aurka-birc5-2 1 16 unspecified role unspecified role prey prey human Homo sapiens Human 15 unspecified role unspecified role prey prey human Homo sapiens Human 11 unspecified role unspecified role bait bait GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human association association incenp-aurka-1 4 14 unspecified role unspecified role bait bait Region 826-918 Region 826-918 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecolx Escherichia coli 11 unspecified role unspecified role prey prey ecolx Escherichia coli direct interaction direct interaction incenp-aurkb-2 9 12 unspecified role unspecified role prey prey ecolx Escherichia coli 14 unspecified role unspecified role bait bait Region 826-918 Region 826-918 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecolx Escherichia coli direct interaction direct interaction