DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation De Domenico I., Lo E., Ward DM., Kaplan J. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined De Domenico I., Lo E., Ward DM., Kaplan J. DIP original experiment: DIP-216518X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation De Domenico I., Lo E., Ward DM., Kaplan J. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western De Domenico I., Lo E., Ward DM., Kaplan J. DIP original experiment: DIP-216522X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation De Domenico I., Lo E., Ward DM., Kaplan J. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot De Domenico I., Lo E., Ward DM., Kaplan J. DIP original experiment: DIP-216517X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation De Domenico I., Lo E., Ward DM., Kaplan J. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined De Domenico I., Lo E., Ward DM., Kaplan J. DIP original experiment: DIP-216521X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation De Domenico I., Lo E., Ward DM., Kaplan J. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined De Domenico I., Lo E., Ward DM., Kaplan J. DIP original experiment: DIP-216519X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation De Domenico I., Lo E., Ward DM., Kaplan J. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western De Domenico I., Lo E., Ward DM., Kaplan J. DIP original experiment: DIP-216520X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. s40a1_mouse Solute carrier family 40 member 1 Slc40a1 Fpn1 Ireg1 Slc11a3 Slc39a1 Ferroportin-1 Iron-regulated transporter 1 Metal transporter protein 1 protein protein mouse Mus musculus Mouse MTKARDQTHQEGCCGSLANYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKNELLTMYHGWVLTVCYILIITIANIANLASTATAITIQRDWIVVVAGENRSRLADMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYFLLWKVYQKTPALAVKAALKVEESELKQLTSPKDTEPKPLEGTHLMGEKDSNIRELECEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLFSGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFVNVEPVSPTTKIPETVFTTEMHMSNMSNVHEMSTKPIPIVSVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHLMYFRFAQKTLGNQIFVCGPDEKEVTDENQPNTSVV DIP protein Q9JHI9 original sequence version: 75 7125CC6171394A0A jak2_human Tyrosine-protein kinase JAK2 Janus kinase 2 JAK2 protein protein human Homo sapiens Human MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG DIP protein O60674 original sequence version: 119 DIP protein O60674 original sequence version: 126 DIP protein O60674 original sequence version: 137 DIP protein O60674 original sequence version: 129 C30669EF1A7DA80C jak2_mouse Tyrosine-protein kinase JAK2 Janus kinase 2 Jak2 protein protein mouse Mus musculus Mouse MGMACLTMTEMEATSTSPVHQNGDIPGSANSVKQIEPVLQVYLYHSLGQAEGEYLKFPSGEYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHDILYRIRFYFPHWYCSGSSRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKEKDQTPLAVYNSVSYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDVQLYCDFPDIIDVSIKQANQECSNESRIVTVHKQDGKVLEIELSSLKEALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKRNFSNLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVQISPTLQRHNNVNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELANLINNCMDYEPDFRPAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVDQIRDSIAA DIP protein Q62120 original sequence version: 149 DIP protein Q62120 original sequence version: 109 DIP protein Q62120 original sequence version: 117 DIP protein Q62120 original sequence version: 110 7BA35989B880D0A6 slc40a1-jak2-1 3 9 unspecified role unspecified role prey prey mouse Mus musculus Mouse 7 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association slc40a1-slc40a1-1 6 7 unspecified role unspecified role prey prey GFP tag GFP tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 7 unspecified role unspecified role bait bait Flag Tag Flag Tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human physical association physical association slc40a1-slc40a1-2 2 7 unspecified role unspecified role bait bait GFP tag GFP tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 7 unspecified role unspecified role prey prey Flag Tag Flag Tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human physical association physical association slc40a1-jak2-2 1 7 unspecified role unspecified role bait bait human Homo sapiens Human 8 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association slc40a1-jak2-3 4 7 unspecified role unspecified role bait bait GFP tag GFP tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 8 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association slc40a1-jak2-4 5 7 unspecified role unspecified role bait bait Q9JHI9:p.Cys326Tyr C326Y mutation mutation disrupting mutation disrupting interaction mutation disrupting predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain C Y This feature has been corrected as a result of our quality control procedures. The original label was 'C326Y mutation'. Wed May 02 14:26:48 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys326tyr' Tue Jun 30 19:47:04 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys326Tyr' Flag tag Flag tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 8 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association