DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The unfolded protein response signals through high-order assembly of Ire1. The unfolded protein response signals through high-order assembly of Ire1. Nature 2009 imex curation Korennykh AV., Egea PF., Korostelev AA., Finer-Moore J., Zhang C., Shokat KM., Stroud RM., Walter P. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Korennykh AV., Egea PF., Korostelev AA., Finer-Moore J., Zhang C., Shokat KM., Stroud RM., Walter P. DIP original experiment: DIP-249772X Nature 2009 IMEx The unfolded protein response signals through high-order assembly of Ire1. The unfolded protein response signals through high-order assembly of Ire1. The unfolded protein response signals through high-order assembly of Ire1. Nature 2009 imex curation Korennykh AV., Egea PF., Korostelev AA., Finer-Moore J., Zhang C., Shokat KM., Stroud RM., Walter P. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Korennykh AV., Egea PF., Korostelev AA., Finer-Moore J., Zhang C., Shokat KM., Stroud RM., Walter P. DIP original experiment: DIP-249771X Nature 2009 IMEx The unfolded protein response signals through high-order assembly of Ire1. ire1_yeast Serine/threonine-protein kinase/endoribonuclease IRE1 IRE1 ERN1 YHR079C Endoplasmic reticulum-to-nucleus signaling 1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MRLLRRNMLVLTLLVCVFSSIISCSIPLSSRTSRRQIVEDEVASTKKLNFNYGVDKNINSPIPAPRTTEGLPNMKLSSYPTPNLLNTADNRRANKKGRRAANSISVPYLENRSLNELSLSDILIAADVEGGLHAVDRRNGHIIWSIEPENFQPLIEIQEPSRLETYETLIIEPFGDGNIYYFNAHQGLQKLPLSIRQLVSTSPLHLKTNIVVNDSGKIVEDEKVYTGSMRTIMYTINMLNGEIISAFGPGSKNGYFGSQSVDCSPEEKIKLQECENMIVIGKTIFELGIHSYDGASYNVTYSTWQQNVLDVPLALQNTFSKDGMCIAPFRDKSLLASDLDFRIARWVSPTFPGIIVGLFDVFNDLRTNENILVPHPFNPGDHESISSNKVYLDQTSNLSWFALSSQNFPSLVESAPISRYASSDRWRVSSIFEDETLFKNAIMGVHQIYNNEYDHLYENYEKTNSLDTTHKYPPLMIDSSVDTTDLHQNNEMNSLKEYMSPEDLEAYRKKIHEQISRELDEKNQNSLLLKFGSLVYRIIETGVFLLLFLIFCAILQRFKILPPLYVLLSKIGFMPEKEIPIVESKSLNCPSSSENVTKPFDMKSGKQVVFEGAVNDGSLKSEKDNDDADEDDEKSLDLTTEKKKRKRGSRGGKKGRKSRIANIPNFEQSLKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS BD65D74E74365945 BD65D74E74365945 ire1kr-1 2 3 unspecified role unspecified role unspecified role unspecified role Region 641-864/893-1115 Region 641-864/893-1115 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ire1kr-2 1 3 unspecified role unspecified role unspecified role unspecified role Region 673-1115 Region 673-1115 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction