DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nature structural & molecular biology 2008 imex curation Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113529X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nature structural & molecular biology 2008 imex curation Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113534X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nature structural & molecular biology 2008 imex curation Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113530X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nature structural & molecular biology 2008 imex curation Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113533X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nature structural & molecular biology 2008 imex curation Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113532X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nature structural & molecular biology 2008 imex curation Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113531X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. cbp_human CREB-binding protein CREBBP CBP Histone lysine acetyltransferase CREBBP Protein-lysine acetyltransferase CREBBP protein protein human Homo sapiens Human MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL DIP protein Q92793 original sequence version: 134 DIP protein Q92793-1 original sequence version: 171 DIP protein Q92793 original sequence version: 171 DIP protein Q92793 original sequence version: 185 DIP protein Q92793 original sequence version: 106 DIP protein Q92793 original sequence version: 104 DIP protein Q92793 original sequence version: 112 DIP protein Q92793 original sequence version: 135 DIP protein Q92793 original sequence version: 139 DIP protein Q92793 original sequence version: 157 DIP protein Q92793 original sequence version: 177 DIP protein Q92793 original sequence version: 168 DIP protein Q92793-1 original sequence version: 174 DIP protein Q92793 original sequence version: 146 DIP protein Q92793 original sequence version: 161 DIP protein Q92793 original sequence version: 172 3BEA9B8558BA1A5E irf5_human Interferon regulatory factor 5 IRF5 protein protein human Homo sapiens Human MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ DIP protein Q13568 original sequence version: 67 01B2ED95C28384E8 crebbp-irf5-1 6 7 unspecified role unspecified role unspecified role unspecified role Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 8 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction crebbp-irf5-2 1 7 unspecified role unspecified role unspecified role unspecified role Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 8 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction irf5-1 2 8 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction irf5-2 5 8 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction crebbp-irf5-3 3 7 unspecified role unspecified role unspecified role unspecified role Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 8 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction irf5-3 4 8 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction