DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Nature 2008 imex curation Ziegenfuss JS., Biswas R., Avery MA., Hong K., Sheehan AE., Yeung YG., Stanley ER., Freeman MR. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Ziegenfuss JS., Biswas R., Avery MA., Hong K., Sheehan AE., Yeung YG., Stanley ER., Freeman MR. DIP original experiment: DIP-250372X Nature 2008 IMEx Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Nature 2008 imex curation Ziegenfuss JS., Biswas R., Avery MA., Hong K., Sheehan AE., Yeung YG., Stanley ER., Freeman MR. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Ziegenfuss JS., Biswas R., Avery MA., Hong K., Sheehan AE., Yeung YG., Stanley ER., Freeman MR. DIP original experiment: DIP-250373X Nature 2008 IMEx Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Nature 2008 imex curation Ziegenfuss JS., Biswas R., Avery MA., Hong K., Sheehan AE., Yeung YG., Stanley ER., Freeman MR. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Ziegenfuss JS., Biswas R., Avery MA., Hong K., Sheehan AE., Yeung YG., Stanley ER., Freeman MR. DIP original experiment: DIP-250371X Nature 2008 IMEx Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. shark_drome Tyrosine-protein kinase Shark Shark Tk7 CG18247 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MSRDSDPMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFARDPDYQNLPELVQTVHI DIP protein Q24145 original sequence version: 113 37CC2C3DA25D3F52 drpr_drome Protein draper drpr Megf10 CG2086 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MLPVILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPPRCSTYRIKHRVVNKTKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNCDELIASQRIADQSENSSRASVALTLVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVHYTHDTNPPSWPPNHNFDNPVYGMQAETRLLPNNMRSKMNNFDQRSTMSTDYGDDCNASGRVGSYSINYNHDLLTKNLNADRTNPIVYNESLKEEHVYDEIKHKEGYKDPDEYDHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPTEPEPQHECFDNTNTNLDNVSTASPSSSPKFLK DIP protein Q9W0A0 original sequence version: 95 A6A0104917D060A9 drpr-shark-1 2 4 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly 5 unspecified role unspecified role bait bait Q9W0A0:p.Tyr949Phe Y949F mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y F This feature has been corrected as a result of our quality control procedures. The original label was 'Y949F'. Wed May 02 18:08:14 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr949phe' Tue Jun 30 15:51:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr949Phe' HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association shark-drpr-1 3 4 unspecified role unspecified role bait bait Region 10-468 Region 10-468 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 5 unspecified role unspecified role prey prey yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast physical association physical association shark-drpr-2 1 4 unspecified role unspecified role bait bait Region 10-468 Region 10-468 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 5 unspecified role unspecified role prey prey Q9W0A0:p.Tyr949Phe Y949F mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y F This feature has been corrected as a result of our quality control procedures. The original label was 'Y949F'. Wed May 02 20:06:57 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr949phe' Tue Jun 30 16:17:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr949Phe' Q9W0A0:p.Tyr934Phe T934F mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y F Wed May 02 18:32:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr934phe' Tue Jun 30 18:34:20 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr934Phe' yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast physical association physical association