DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Identification of a serotonin/glutamate receptor complex implicated in psychosis. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 2008 imex curation González-Maeso J., Ang RL., Yuen T., Chan P., Weisstaub NV., López-Giménez JF., Zhou M., Okawa Y., Callado LF., Callado LF., Milligan G., Gingrich JA., Filizola M., Meana JJ., Sealfon SC. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined González-Maeso J., Ang RL., Yuen T., Chan P., Weisstaub NV., López-Giménez JF., Zhou M., Okawa Y., Callado LF., Callado LF., Milligan G., Gingrich JA., Filizola M., Meana JJ., Sealfon SC. DIP original experiment: DIP-250278X Nature 2008 IMEx Identification of a serotonin/glutamate receptor complex implicated in psychosis. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 2008 imex curation González-Maeso J., Ang RL., Yuen T., Chan P., Weisstaub NV., López-Giménez JF., Zhou M., Okawa Y., Callado LF., Callado LF., Milligan G., Gingrich JA., Filizola M., Meana JJ., Sealfon SC. Only protein-protein interactions human Homo sapiens Human bret bioluminescence resonance energy transfer BRET LRET LRET BRET bret predetermined predetermined participant predetermined González-Maeso J., Ang RL., Yuen T., Chan P., Weisstaub NV., López-Giménez JF., Zhou M., Okawa Y., Callado LF., Callado LF., Milligan G., Gingrich JA., Filizola M., Meana JJ., Sealfon SC. DIP original experiment: DIP-250279X Nature 2008 IMEx Identification of a serotonin/glutamate receptor complex implicated in psychosis. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 2008 imex curation González-Maeso J., Ang RL., Yuen T., Chan P., Weisstaub NV., López-Giménez JF., Zhou M., Okawa Y., Callado LF., Callado LF., Milligan G., Gingrich JA., Filizola M., Meana JJ., Sealfon SC. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined González-Maeso J., Ang RL., Yuen T., Chan P., Weisstaub NV., López-Giménez JF., Zhou M., Okawa Y., Callado LF., Callado LF., Milligan G., Gingrich JA., Filizola M., Meana JJ., Sealfon SC. DIP original experiment: DIP-250277X Nature 2008 IMEx Identification of a serotonin/glutamate receptor complex implicated in psychosis. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 2008 imex curation González-Maeso J., Ang RL., Yuen T., Chan P., Weisstaub NV., López-Giménez JF., Zhou M., Okawa Y., Callado LF., Callado LF., Milligan G., Gingrich JA., Filizola M., Meana JJ., Sealfon SC. Only protein-protein interactions human Homo sapiens Human fret fluorescent resonance energy transfer FRET RET FRET analysis FRET RET FRET analysis fret predetermined predetermined participant predetermined González-Maeso J., Ang RL., Yuen T., Chan P., Weisstaub NV., López-Giménez JF., Zhou M., Okawa Y., Callado LF., Callado LF., Milligan G., Gingrich JA., Filizola M., Meana JJ., Sealfon SC. DIP original experiment: DIP-250280X Nature 2008 IMEx Identification of a serotonin/glutamate receptor complex implicated in psychosis. p28223-1 5-hydroxytryptamine receptor 2A HTR2A HTR2 Serotonin receptor 2A protein protein human Homo sapiens Human MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV DIP protein P28223-1 original sequence version: 151 DIP protein P28223 original sequence version: 127 DIP protein P28223 original sequence version: 159 grm2_human Metabotropic glutamate receptor 2 GRM2 GPRC1B MGLUR2 protein protein human Homo sapiens Human MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL DIP protein Q14416 original sequence version: 97 801976D034AA8100 htr2a-grm2-1 3 5 unspecified role unspecified role bait bait human Homo sapiens Human 6 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association htr2a-grm2-2 4 6 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept eYFP-tag eYFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 5 unspecified role unspecified role fluorescence donor fluorescence donor eCFP-tag eCFP-tag cfp tag cyan fluorescent protein tag CFP cyan fluorescent protein cyan fluorescent protein CFP cfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human direct interaction direct interaction htr2a-grm2-3 1 5 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 6 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association grm2-htr2a-5 2 6 unspecified role unspecified role fluorescence donor fluorescence donor Rluc-tag Rluc-tag renilla luciferase renilla luciferase protein tag renilla luciferase c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 5 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human direct interaction direct interaction