DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nature structural & molecular biology 2008 imex curation Lee J., Thompson JR., Botuyan MV., Mer G. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Lee J., Thompson JR., Botuyan MV., Mer G. DIP original experiment: DIP-113694X Nature structural & molecular biology 2008 IMEx Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nature structural & molecular biology 2008 imex curation Lee J., Thompson JR., Botuyan MV., Mer G. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Lee J., Thompson JR., Botuyan MV., Mer G. DIP original experiment: DIP-113695X Nature structural & molecular biology 2008 IMEx Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nature structural & molecular biology 2008 imex curation Lee J., Thompson JR., Botuyan MV., Mer G. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Lee J., Thompson JR., Botuyan MV., Mer G. DIP original experiment: DIP-113696X Nature structural & molecular biology 2008 IMEx Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. h3k4me3 Histone 3 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) ARTKQTARKS h4k20me3 Histone 4 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) KRHRKVLRDN o75164-1 Lysine-specific demethylase 4A [histone H3]-trimethyl-L-lysine(36) demethylase 4A [histone H3]-trimethyl-L-lysine(9) demethylase 4A KDM4A JHDM3A JMJD2 JMJD2A KIAA0677 JmjC domain-containing histone demethylation protein 3A Jumonji domain-containing protein 2A protein protein human Homo sapiens Human MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELPPRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTGVLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDINLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME DIP protein O75164-1 original sequence version: 120 DIP protein O75164 original sequence version: 66 DIP protein O75164 original sequence version: 76 DIP protein O75164-1 original sequence version: 130 DIP protein O75164-1 original sequence version: 116 h4k20me3-kdm4a-1 3 5 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 6 unspecified role unspecified role unspecified role unspecified role Region 897-1011 Region 897-1011 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction h4k20me3-kdm4a-2 1 5 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 6 unspecified role unspecified role unspecified role unspecified role Region 897-1011 Region 897-1011 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain O75164-1:p.Asp939Arg D939R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D R This feature has been corrected as a result of our quality control procedures. The original label was 'D939R'. Wed May 02 16:25:26 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp939arg' Tue Jun 30 18:26:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp939Arg' ecolx Escherichia coli direct interaction direct interaction h3k4me3-kdm4a-1 2 4 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 6 unspecified role unspecified role unspecified role unspecified role Region 897-1011 Region 897-1011 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain O75164-1:p.Asp945Arg D945R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D R This feature has been corrected as a result of our quality control procedures. The original label was 'D945R'. Wed May 02 19:52:27 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp945arg' Tue Jun 30 18:50:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp945Arg' ecolx Escherichia coli direct interaction direct interaction