DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu L3MBTL1 recognition of mono- and dimethylated histones. L3MBTL1 recognition of mono- and dimethylated histones. Nature structural & molecular biology 2007 imex curation Min J., Allali-Hassani A., Nady N., Qi C., Ouyang H., Liu Y., MacKenzie F., Vedadi M., Arrowsmith CH. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Min J., Allali-Hassani A., Nady N., Qi C., Ouyang H., Liu Y., MacKenzie F., Vedadi M., Arrowsmith CH. DIP original experiment: DIP-68380X Nature structural & molecular biology 2007 IMEx L3MBTL1 recognition of mono- and dimethylated histones. L3MBTL1 recognition of mono- and dimethylated histones. L3MBTL1 recognition of mono- and dimethylated histones. Nature structural & molecular biology 2007 imex curation Min J., Allali-Hassani A., Nady N., Qi C., Ouyang H., Liu Y., MacKenzie F., Vedadi M., Arrowsmith CH. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Min J., Allali-Hassani A., Nady N., Qi C., Ouyang H., Liu Y., MacKenzie F., Vedadi M., Arrowsmith CH. DIP original experiment: DIP-68381X Nature structural & molecular biology 2007 IMEx L3MBTL1 recognition of mono- and dimethylated histones. L3MBTL1 recognition of mono- and dimethylated histones. L3MBTL1 recognition of mono- and dimethylated histones. Nature structural & molecular biology 2007 imex curation Min J., Allali-Hassani A., Nady N., Qi C., Ouyang H., Liu Y., MacKenzie F., Vedadi M., Arrowsmith CH. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Min J., Allali-Hassani A., Nady N., Qi C., Ouyang H., Liu Y., MacKenzie F., Vedadi M., Arrowsmith CH. DIP original experiment: DIP-68382X Nature structural & molecular biology 2007 IMEx L3MBTL1 recognition of mono- and dimethylated histones. L3MBTL1 recognition of mono- and dimethylated histones. L3MBTL1 recognition of mono- and dimethylated histones. Nature structural & molecular biology 2007 imex curation Min J., Allali-Hassani A., Nady N., Qi C., Ouyang H., Liu Y., MacKenzie F., Vedadi M., Arrowsmith CH. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Min J., Allali-Hassani A., Nady N., Qi C., Ouyang H., Liu Y., MacKenzie F., Vedadi M., Arrowsmith CH. DIP original experiment: DIP-68383X Nature structural & molecular biology 2007 IMEx L3MBTL1 recognition of mono- and dimethylated histones. lmbl1_human Lethal(3)malignant brain tumor-like protein 1 L3MBTL1 KIAA0681 L3MBT L3MBTL1 L(3)mbt protein homolog L3MBTL protein protein human Homo sapiens Human MHLVAGDSPGSGPHLPATAFIIPASSATLGLPSSALDVSCFPREPIHVGAPEQVAGCEPVSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEARIVRVTHVSGKTLVWTVAQLGDLVCSDHLQEGKGILETGVHSLLCSLPTHLLAKLSFASDSQY DIP protein Q9Y468 original sequence version: 75 DIP protein Q9Y468 original sequence version: 118 DIP protein Q9Y468 original sequence version: 140 DIP protein Q9Y468 original sequence version: 119 70004D458897CB24 h4k20-1 H4K20 peptide (12-30) protein protein human Homo sapiens Human YKGGAKRHRKVLRDNIQGIT h4k20 H4K20 peptide (17-25) protein protein human Homo sapiens Human AKRHRKVLRDN h1bk26 H1bK26 peptide protein protein human Homo sapiens Human KKKARKSAGAAK h4k20-l3mbtl1-1 1 7 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) 5 unspecified role unspecified role neutral component neutral component 200-522 binding region 200-522 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction h4k20-l3mbtl1-2 2 6 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) 5 unspecified role unspecified role neutral component neutral component 200-522 binding region 200-522 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction h1bk26-l3mbtl1-1 4 8 unspecified role unspecified role neutral component neutral component K6 monomethylation K6 monomethylation n6me1lys N6-methyl-L-lysine (2S)-2-amino-6-methylaminohexanoic acid MOD_RES N6-methyllysine N(zeta)-methyllysine N6-methyl-L-lysine N6-methylated L-lysine epsilon-methyllysine Methyl Methylation N-methyl Lysyl N6Me1Lys modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain K6 dimethylation K6 dimethylation n6me2lys N6,N6-dimethyl-L-lysine (2S)-2-amino-6-(dimethylamino)hexanoic acid MOD_RES N6,N6-dimethyllysine N(zeta)-dimethyllysine N6,N6-dimethyl-L-lysine N6,N6-dimethylated L-lysine epsilon-dimethyllysine lysine derivative Lys(y) Dimethyl N6Me2Lys di-Methylation dimethylk modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain chemical synthesis Chemical synthesis (Chemical synthesis) 5 unspecified role unspecified role neutral component neutral component 200-522 binding region 200-522 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain Q9Y468:p.Cys431Phe C363F mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain C F Thu Apr 12 11:26:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys363phe' This feature has been corrected as a result of our quality control procedures. The original label was 'C363F mutation'. Wed May 02 18:00:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys431phe' Tue Jun 30 16:49:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys431Phe' Q9Y468:p.Cys431Arg C363R mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain C R Thu Apr 12 11:30:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys363arg' This feature has been corrected as a result of our quality control procedures. The original label was 'C363R mutation'. Wed May 02 18:50:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys431arg' Tue Jun 30 17:26:22 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys431Arg' Q9Y468:p.Asp423Asn D355N mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D N Thu Apr 12 11:16:16 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp355asn' This feature has been corrected as a result of our quality control procedures. The original label was 'D355N mutation'. Wed May 02 14:24:34 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp423asn' Tue Jun 30 17:55:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp423Asn' Q9Y468:p.Asp423Ala D355A mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D A Thu Apr 12 11:27:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp355ala' This feature has been corrected as a result of our quality control procedures. The original label was 'D355A mutation'. Wed May 02 19:39:13 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp423ala' Tue Jun 30 16:32:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp423Ala' Q9Y468:p.Phe447Ala F379A mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F A Thu Apr 12 11:44:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe379ala' This feature has been corrected as a result of our quality control procedures. The original label was 'F379A mutation'. Wed May 02 16:15:25 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe447ala' Tue Jun 30 15:45:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe447Ala' Q9Y468:p.Trp450Ala W382A mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain W A Thu Apr 12 11:46:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp382ala' This feature has been corrected as a result of our quality control procedures. The original label was 'W382A mutation'. Wed May 02 15:11:59 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp450ala' Tue Jun 30 19:49:34 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp450Ala' Q9Y468:p.Trp450Leu W382L mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain W L Thu Apr 12 11:17:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp382leu' This feature has been corrected as a result of our quality control procedures. The original label was 'W382L mutation'. Wed May 02 20:00:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp450leu' Tue Jun 30 18:05:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp450Leu' Q9Y468:p.Tyr454Leu Y386L mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain Y L Thu Apr 12 11:21:55 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr386leu' This feature has been corrected as a result of our quality control procedures. The original label was 'Y386L mutation'. Wed May 02 18:45:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr454leu' Tue Jun 30 19:35:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr454Leu' Q9Y468:p.Tyr454Ala Y386A mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain Y A Thu Apr 12 11:12:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr386ala' This feature has been corrected as a result of our quality control procedures. The original label was 'Y386A mutation'. Wed May 02 19:25:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr454ala' Tue Jun 30 19:56:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr454Ala' ecolx Escherichia coli direct interaction direct interaction h4k20-l3mbtl1-3 3 7 unspecified role unspecified role neutral component neutral component K6 monomethylation K6 monomethylation n6me1lys N6-methyl-L-lysine (2S)-2-amino-6-methylaminohexanoic acid MOD_RES N6-methyllysine N(zeta)-methyllysine N6-methyl-L-lysine N6-methylated L-lysine epsilon-methyllysine Methyl Methylation N-methyl Lysyl N6Me1Lys modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain K6 dimethylation K6 dimethylation n6me2lys N6,N6-dimethyl-L-lysine (2S)-2-amino-6-(dimethylamino)hexanoic acid MOD_RES N6,N6-dimethyllysine N(zeta)-dimethyllysine N6,N6-dimethyl-L-lysine N6,N6-dimethylated L-lysine epsilon-dimethyllysine lysine derivative Lys(y) Dimethyl N6Me2Lys di-Methylation dimethylk modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain chemical synthesis Chemical synthesis (Chemical synthesis) 5 unspecified role unspecified role neutral component neutral component 200-522 binding region 200-522 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction