DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure (London, England : 1993) 2007 imex curation Samel SA., Schoenafinger G., Knappe TA., Marahiel MA., Essen LO. Only protein-protein interactions in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Samel SA., Schoenafinger G., Knappe TA., Marahiel MA., Essen LO. DIP original experiment: DIP-67809X Structure (London, England : 1993) 2007 IMEx Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure (London, England : 1993) 2007 imex curation Samel SA., Schoenafinger G., Knappe TA., Marahiel MA., Essen LO. Only protein-protein interactions in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Samel SA., Schoenafinger G., Knappe TA., Marahiel MA., Essen LO. DIP original experiment: DIP-67808X Structure (London, England : 1993) 2007 IMEx Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. tycc_brepa Tyrocidine synthase 3 tycC Tyrocidine synthase III protein protein brepa Brevibacillus parabrevis MKKQENIAKIYPLTPLQEGMLFHAVTDTGSSAYCLQMSATIEGDFHLPLFEKSLNKLVENYEVLRTAFVYQNMQRPRQVVFKERKVTVPCENIAHLPSAEQDAYIQAYTKQHHAFDLTKDNLMKAAIFQTAENKYRLVWAFHHIIVDGWTLGVLLHKLLTYYAALRKGEPIPREATKPYSEYIKWLDKQNKDEALAYWQNYLAGYDHQAAFPKKKLGTEASRYEHVEAMFTIAPEKTQQLIQIANQNQATMSSVFQALWGILASTYKNADDVVFGSVVSGRPPQIQGIESMVGLFINTIPTRVQTNKQQTFSELLQTVQKQALASATYDFAPLYEIQSTTVLKQELIDHLVTFENYPDHSMKHLEESLGFQFTVESGDEQTSYDLNVVVALAPSNELYVKLSYNAAVYESSFVNRIEGHLRTVIDQVIGNPHVHLHEIGIITEEEKQQLLVAYNDTAAEYPRDKTIFELIAEQASRTPAKAAVVCGEDTLTYQELMERSAQLANALREKGIASGSIVSIMAEHSLELIVAIMAVLRSGAAYLPIDPEYPQDRIQYLLDDSQTTLLLTQSHLQPNIRFAGSVLYLDDRSLYEGGSTSFAPESKPDDLAYMIYTSGSTGNPKGAMITHQGLVNYIWWANKVYVQGEAVDFPLYSSISFDLTVTSIFTPLLSGNTIHVYRGADKVQVILDIIKDNKVGIIKLTPTHLKLIEHIDGKASSIRRFIVGGENLPTKLAKQIYDHFGENVQIFNEYGPTETVVGCMIYLYDPQTTTQESVPIGVPADNVQLYLLDASMQPVPVGSLGEMYIAGDGVAKGYFNRPELTKEKFIDNPFRPGTKMYRTGDLAKWLPDGNMEYAGRMDYQVKIRGHRIEMGEIETRLTQHEAVKEAVVIVEKDESGQNVLYAYLVSERELTVAELREFLGRTLPSYMIPSFFIRLAEIPLTANGKVERKKLPKPAGAVVTGTAYAAPQNEIEAKLAEIWQQVLGISQVGIHDDFFDLGGHSLKAMTVVFQVSKALEVELPVKALFEHPTVAELARFLSRSEKTEYTAIQPVAAQEFYPVSSAQKRMYILQQFEGNGISYNISGAILLEGKLDYARFASAVQQLAERHEALRTSFHRIDGEPVQKVHEEVEVPLFMLEAPEDQAEKIMREFVRPFDLGVAPLMRTGLLKLGKDRHLFLLDMHHIISDGVSSQILLREFAELYQGADLQPLSLQYKDFAAWQNELFQTEAYKKQEQHWLNTFADEIPLLNLPTDYPRPSVQSFAGDLVLFAAGKELLERLQQVASETGTTLYMILLAAYNVLLSKYTGQEDIIVGTPVAGRSHADVENIMGIFVNTLALRNQPASSKTFAQFLQEVKQNALAAYDHQDYPFEELVEKLAIQRDISRNPLFDTLFSLENANQQSLAIAELTASPYELFNKISKFDLALNASESPADIQFQLTFATKLFKKETVERMARHYLEILRWISEQPTASLADIDMMTEAEKRTLLLNVNDTFVERTAATALHQLVEEQAARTPDEVAVVYEEYALTYRELNARANQLARLLRSHGTGPDTLIGIMVDRSPGMVVGMLAVLKAGGAYTPIDPSYPPERIQYMLSDSQAPILLTQRHLQELAAYQGEIIDVDEEAIYTGADTNLDNVAGKDDLAYVIYTSGSTGNPKGVMISHQAICNHMLWMRETFPLTTEDAVLQKTPFSFDASVWEFYLPLITGGQLVLAKPDGHRDIAYMTRLIRDEKITTLQMVPSLLDLVMTDPGWSACTSLQRVFCGGEALTPALVSRFYETQQAQLINLYGPTETTIDATYWPCPRQQEYSAIPIGKPIDNVRLYVVNASNQLQPVGVAGELCIAGDGLARGYWQREELTKASFVDNPFEPGGTMYRTGDMVRYLPDGHIEYLGRIDHQVKIRGHRIELGEIEATLLQHEAVKAVVVMARQDGKGQNSLYAYVVAEQDIQTAELRTYLSATLPAYMVPSAFVFLEQLPLSANGKVDRKALPQPEDAAASAAVYVAPRNEWEAKLAAIWESVLGVEPIGVHDHFFELGGHSLKAMHVISLLQRSFQVDVPLKVLFESPTIAGLAPLVAAARKGTYTAIPPVEKQEYYPVSAAQKRMFILQQMEGAGISYNMPGFMYLDGKLDTERLQQALKSLVQRHESLRTSFHSVQGETVQRVHDDVDLAISFGEATEAETRQIAEQFIQPFDLGTAPLLRAGLIKLAPERHLFMLDLHHIVVDGVSIGLLIEEFAQLYHGEELPALRIQYKDFAKWQQDWFQTEEFAEQEAYWLNTFTGEIPVLNLPTDYPRPSVKSFAGDRFVFGSGTALPKQLHQLAQETGTTLYMVLLAAYNVLLSKYSRQEDIIVGAPTAGRSHAETESIVGMFVNTLALRNEPAGGKTFRDFLAEVKINTLGAFEHQDYPLDELVDKLDMQRDLSRNPLFDTVFILQNMEQKPFEMEQLTITPYSAEVKQAKFDLSLEAYEENAEIIFSLDYSTKLFSRETIEKIATHFIQILRAVIAEPEMPLSEITMLTEAEKQRLLVDFNGAHKDFPQNKTLQALFEEQAEKSPQATAVEISGQPLSYQELNERANQLAATLRERGVQPDQPVGIMANRSVEMVVGILAILKAGGAYVPIDPEYPEERVAYMLTDCQARLVLTQKHLGAKLGSSVTAECLYLDDESNYGVHRSNLQPINTASDLAYIIYTSGTTGKPKGVMVEHRGIVNNVLWKKAEYQMKVGDRSLLSLSFAFDAFVLSFFTPVLSGATVVLAEDEEAKDPVSLKKLIAASRCTLMTGVPSLFQAILECSTPADIRPLQTVTLGGEKITAQLVEKCKQLNPDLVIVNEYGPTESSVVATWQRLAGPDAAITIGRPIANTSLYIVNQYHQLQPIGVVGEICIGGRGLARGYWNKPALTEEKFVSHPFAAGERMYKTGDLGKWLPDGTIEYIGRIDEQVKVRGYRIEIGEIESALLAAEKLTAAVVVVYEDQLGQSALAAYFTADEQLDVTKLWSHLSKRLPSYMIPAHFVQLDQLPLTPNGKVDKKALPKPEGKPVTEAQYVAPTNAVESKLAEIWERVLGVSGIGILDNFFQIGGHSLKAMAVAAQVHREYQVELPLKVLFAQPTIKALAQYVATSGKETYVPIEPAPLQEYYPVSSAQKRMYVLRQFADTGTVYNMPSALYIEGDLDRKRFEAAIHGLVERHESLRTSFHTVNGEPVQRVHEHVELNVQYAEVTEAQVEPTVESFVQAFDLTKAPLLRVGLFKLAAKRHLFLLDMHHIISDGVSAGIIMEEFSKLYRGEELPALSVHYKDFAVWQSELFQSDVYTEHENYWLNAFSGDIPVLNLPADFSRPLTQSFEGDCVSFQADKALLDDLHKLAQESQSTLFMVLLAAYNVLLAKYSGQEDIVVGTPIAGRSHADIENVLGMFVNTLALRNYPVETKHFQAFLEEVKQNTLQAYAHQDYPFEALVEKLDIQRDLSRNPLFDTMFILQNLDQKAYELDGLKLEAYPAQAGNAKFDLTLEAHEDETGIHFALVYSTKLFQRESIERMAGHFLQVLRQVVADQATALREISLLSEEERRIVTVDFNNTFAAYPRDLTIQELFEQQAAKTPEHAAVVMDGQMLTYRELNEKANQLAHVLRQNGVGKESIVGLLADRSLEMITGIMGILKAGGAYLGLDPEHPSERLAYMLEDGGVKVVLVQKHLLPLVGEGLMPIVLEEESLRPEDCGNPAIVNGASDLAYVMYTSGSTGKPKGVMVEHRNVTRLVMHTNYVQVRESDRMIQTGAIGFDAMTFEIFGALLHGASLYLVSKDVLLDAEKLGDFLRTNQITTMWLTSPLFNQLSQDNPAMFDSLRALIVGGEALSPKHINRVKSALPDLEIWNGYGPTENTTFSTCYLIEQHFEEQIPIGKPIANSTAYIVDGNNQPQPIGVPGELCVGGDGVARGYVNKPELTAEKFVPNPFAPGETMYRTGDLARWLPDGTIEYLGRIDQQVKIRGYRIELGEIETVLSQQAQVKEAVVAVIEEANGQKALCAYFVPEQAVDAAELREAMSKQLPGYMVPAYYVQMEKLPLTANGKVDRRALPQPSGERTTGSAFVAAQNDTEAKLQQIWQEVLGIPAIGIHDNFFEIGGHSLKAMNVITQVHKTFQVELPLKALFATPTIHELAAHIAESAFEQFETIQPVEPAAFYPVSFAQKRMYILHQFEGSGISYNVPSVLVLEGKLDYDRFAAAIQSLVKRHESLRTSFHSVNGEPLQRVHPDVELPVRLLEATEDQSESLIQELIQPFDLEIAPLFRVNLIKLGAERHLFFMDMHHIISDGVSLAVIVEEIASLYAGKQLSDLRIQYKDFAVWQTKLAQSDRFQKQEDFWTRTFAGEIPLLNLPHDYPRPSVQSFDGDTVALGTGHHLLEQLRKLAAETGTTLFMVLLAAYHVLLSKYAGQEEIVVGTPIAGRSHADVERIVGMFVNTLALKNTAAGSLSFRAFLEDVKQNALHAFEHQDYPFEHLVEKLQVRRDLSRNPLFDTMFSLGLAESAEGEVADLKVSPYPVNGHIAKFDLSLDAMEKQDGLLVQFSYCTKLFAKETVDRLAAHYVQLLQTITADPDIELARISVLSKAETEHMLHSFLATKTAYPTDKTFQKLFEEQVEKTPNEIAVLFGNEQLTYQELNAKANQLARVLRRKGVKPESTVGILVDRSLYMVIGMLAVLKAGGTFVPIDPDYPLERQAFMLEDSEAKLLLTLQKMNSQVAFPYETFYLDTETVDQEETGNLEHVAQPENVAYIIYTSGTTGKPKGVVIEHRSYANVAFAWKDEYHLDSFPVRLLQMASFAFDVSTGDFARALLTGGQLVICPNGVKMDPASLYETIRRHEITIFEATPALIMPLMHYVYENELDMSQMKLLILGADSCPAEDFKTLLARFGQKMRIINSYGVTEACIDTSYYEETDVTAIRSGTVPIGKPLPNMTMYVVDAHLNLQPVGVVGELCIGGAGVARGYLNRPELTEEKFVPNPFAPGERLYRTGDLAKWRADGNVEFLGRNDHQVKIRGVRIELGEIETQLRKLDGITEAVVVAREDRGQEKELCAYVVADHKLDTAELRANLLKELPQAMIPAYFVTLDALPLTANGKVDRRSLPAPDVTMLRTTEYVAPRSVWEARLAQVWEQVLNVPQVGALDDFFALGGHSLRAMRVLSSMHNEYQVDIPLRILFEKPTIQELAAFIEETAKGNVFSIEPVQKQAYYPVSSAQKRMYILDQFEGVGISYNMPSTMLIEGKLERTRVEAAFQRLIARHESLRTSFAVVNGEPVQNIHEDVPFALAYSEVTEQEARELVSSLVQPFDLEVAPLIRVSLLKIGEDRYVLFTDMHHSISDGVSSGILLAEWVQLYQGDVLPELRIQYKDFAVWQQEFSQSAAFHKQEAYWLQTFADDIPVLNLPTDFTRPSTQSFAGDQCTIGAGKALTEGLHQLAQATGTTLYMVLLAAYNVLLAKYAGQEDIIVGTPITGRSHADLEPIVGMFVNTLAMRNKPQREKTFSEFLQEVKQNALDAYGHQDYPFEELVEKLAIARDLSRNPLFDTVFTFQNSTEEVMTLPECTLAPFMTDETGQHAKFDLTFSATEEREEMTIGVEYSTSLFTRETMERFSRHFLTIAASIVQNPHIRLGEIDMLLPEEKQQILAGFNDTAVSYALDKTLHQLFEEQVDKTPDQAALLFSEQSLTYSELNERANRLARVLRAKGVGPDRLVAIMAERSPEMVIGILGILKAGGAYVPVDPGYPQERIQYLLEDSNAALLLSQAHLLPLLAQVSSELPECLDLNAELDAGLSGSNLPAVNQPTDLAYVIYTSGTTGKPKGVMIPHQGIVNCLQWRRDEYGFGPSDKALQVFSFAFDGFVASLFAPLLGGATCVLPQEAAAKDPVALKKLMAATEVTHYYGVPSLFQAILDCSTTTDFNQLRCVTLGGEKLPVQLVQKTKEKHPAIEINNEYGPTENSVVTTISRSIEAGQAITIGRPLANVQVYIVDEQHHLQPIGVVGELCIGGAGLARGYLNKPELTAEKFVANPFRPGERMYKTGDLVKWRTDGTIEYIGRADEQVKVRGYRIEIGEIESAVLAYQGIDQAVVVARDDDATAGSYLCAYFVAATAVSVSGLRSHLAKELPAYMIPSYFVELDQLPLSANGKVDRKALPKPQQSDATTREYVAPRNATEQQLAAIWQEVLGVEPIGITDQFFELGGHSLKATLLIAKVYEYMQIELPLNLIFQYPTIEKVADFITHKRFESRYGTAILLNQETARNVFCFTPIGAQSVYYQKLAAEIQGVSLYSFDFIQDDNRMEQYIAAITAIDPSGPYTLMGYSSGGNLAFEVAKELEERGYGVTDIILFDSYWKDKAIERTVAETENDIAQLFAEIGENTEMFNMTQEDFQLYAANEFVKQSFVRKTVSYVMFHNNLVNTGMTTAAIHLIQSELEADEEAPVAAKWNESAWANATQRLLTYSGHGIHSRMLAGDYASQNASILQNILQELFILK DIP protein O30409 original sequence version: 64 DIP protein O30409 original sequence version: 90 p3 peptide TycC substrate [APFFNQ] peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) APFFNQ p1 peptide TycC substrate [FPFFNQ] peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) FPFFNQ p3 peptide-tycc-1 1 4 enzyme target enzyme target substrate substrate unspecified role unspecified role in vitro In vitro 3 enzyme enzyme unspecified role unspecified role Region 5116-5633 Region 5116-5633 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction p1 peptide-tycc-1 2 5 enzyme target enzyme target substrate substrate unspecified role unspecified role in vitro In vitro 3 enzyme enzyme unspecified role unspecified role Region 5116-5633 Region 5116-5633 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction