DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261509X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261512X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions ecolx Escherichia coli nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261508X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261515X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions ecolx Escherichia coli light scattering light scattering predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261519X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261511X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions ecolx Escherichia coli crosslink cross-linking study crosslink weight by comassie molecular weight estimation by coomasie staining weight by comassie Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261518X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions in vitro In vitro crosslink cross-linking study crosslink predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261517X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261513X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions ecolx Escherichia coli crosslink cross-linking study crosslink weight by comassie molecular weight estimation by coomasie staining weight by comassie Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261516X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261514X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Hwang E., Ryu KS., Pääkkönen K., Güntert P., Cheong HK., Lim DS., Lee JO., Jeon YH., Cheong C. DIP original experiment: DIP-261510X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. q8www0-1 Ras association domain-containing protein 5 A NORE1A RASSF5 NORE1 RAPL New ras effector 1 Regulator for cell adhesion and polarization enriched in lymphoid tissues protein protein human Homo sapiens Human MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGRSARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERGEGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG DIP protein Q8WWW0-1 original sequence version: 114 DIP protein Q8WWW0-1 original sequence version: 111 DIP protein Q8WWW0-1 original sequence version: 107 4AFBC69B1325CC9E sav1_human Protein salvador homolog 1 SAV1 WW45 45 kDa WW domain protein protein protein human Homo sapiens Human MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF DIP protein Q9H4B6 original sequence version: 102 4012C40A8601417A q13043-1 Serine/threonine-protein kinase 4 STK4 KRS2 MST1 Mammalian STE20-like protein kinase 1 STE20-like kinase MST1 Serine/threonine-protein kinase Krs-2 protein protein human Homo sapiens Human METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF DIP protein Q13043-1 original sequence version: 150 DIP protein Q13043 original sequence version: 86 stk4-6 3 15 unspecified role unspecified role unspecified role unspecified role Region 432-480 Region 432-480 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction sav1-stk4-2 9 14 unspecified role unspecified role unspecified role unspecified role Region 321-373 Region 321-373 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 432-480 Region 432-480 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction rassf5-1 4 13 unspecified role unspecified role unspecified role unspecified role Region 366-413 Region 366-413 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction stk4-2 5 15 unspecified role unspecified role unspecified role unspecified role Region 432-480 Region 432-480 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction rassf5-stk4-1 1 13 unspecified role unspecified role unspecified role unspecified role Region 366-413 Region 366-413 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 432-480 Region 432-480 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction stk4-3 10 15 unspecified role unspecified role unspecified role unspecified role Region 432-480 Region 432-480 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction rassf5-2 7 13 unspecified role unspecified role unspecified role unspecified role Region 366-413 Region 366-413 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction stk4-4 6 15 unspecified role unspecified role unspecified role unspecified role Region 432-480 Region 432-480 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction sav1-1 11 14 unspecified role unspecified role unspecified role unspecified role Region 321-373 Region 321-373 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction rassf5-stk4-2 8 13 unspecified role unspecified role unspecified role unspecified role Region 366-413 Region 366-413 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 432-480 Region 432-480 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction rassf5-stk4-3 2 13 unspecified role unspecified role unspecified role unspecified role Region 366-413 Region 366-413 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 432-480 Region 432-480 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction sav1-stk4-3 12 14 unspecified role unspecified role unspecified role unspecified role Region 321-373 Region 321-373 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role Region 432-480 Region 432-480 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction